Stockholders' Deficit (Tables)

3 Months Ended

Mar. 31, 2023

Equity [Abstract]

Summary of Option Activity under 2018 Plan, 2013 Plan and 2010 Plan

A summary of option activity under the 2018 Plan, 2013 Plan, and 2010 Plan for the three months ended March 31, 2023 and 2022, is as follows:

Year-to-Date Activity	Number of Shares			Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (Years)		Aggregate Intrinsic Value (in Millions)
Options outstanding at December 31, 2022		2,794,850		$	6.36		7.4
Granted		630,000		$	1.67
Cancelled/forfeited		(150,752	)	$	3.83
Options outstanding at March 31, 2023		3,274,098		$	5.58		7.5	$	—
Options exercisable at March 31, 2023		1,780,877		$	8.34		6.1	$	—
Year-to-Date Activity	Number of Shares			Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (Years)		Aggregate Intrinsic Value (in Millions)
Options outstanding at December 31, 2021		1,954,975		$	8.16		7.8
Granted		853,000		$	2.33
Cancelled/forfeited		(11,875	)	$	3.76
Options outstanding at March 31, 2022		2,796,100		$	6.40		8.2	$	0.6
Options exercisable at March 31, 2022		1,285,645		$	9.72		6.8	$	—

Summary of Stock-Based Compensation Expense

The amount of stock-based compensation expense recorded to research and development expenses and to general and administrative expenses is detailed in table below:

	Three Months Ended March 31,
	2023		2022
Stock-based compensation
Research and development	$	169,929	$	140,440
General and administrative		115,580		333,657
Total stock-based compensation expense	$	285,509	$	474,097

Summary of Warrants Issued

	For the three months ended March 31,
	2023				2022
	Number		Weighted Average Exercise Price		Number		Weighted Average Exercise Price
Outstanding at beginning of the period		250,000	$	2.08		—	$	—
Granted during the period		250,000		2.39		150,000		2.46
Outstanding at end of the period		500,000	$	2.24		150,000	$	2.46
Exercisable at end of the period		500,000	$	2.24		150,000	$	2.46
Weighted average remaining life	5.9 years				7.0 years

Warrants issued in March 2023 Offering

	For the three months ended March 31,
	2023
	Number		Weighted Average Exercise Price
Outstanding at beginning of the period		—	$	—
Granted during the period		3,505,612		0.66
Outstanding at end of the period		3,505,612	$	0.66
Exercisable at end of the period		3,505,612	$	0.66
Weighted average remaining life	5.5 years