Leases - Additional Information (Details)			12 Months Ended
	Nov. 17, 2021	Oct. 15, 2021	Dec. 31, 2022 USD ($) ft²	Dec. 31, 2021 USD ($)	Apr. 23, 2019 ft²	Mar. 05, 2019 ft²	Apr. 01, 2018 ft²	Mar. 06, 2018 ft²
Lessee Lease Description [Line Items]
Operating lease right of use asset | $			$ 200,000	$ 400,000
Operating Lease, Right-of-Use Asset, Statement of Financial Position [Extensible Enumeration]			Other Assets, Noncurrent	Other Assets, Noncurrent
Operating lease liability | $			$ 249,590	$ 393,837
Operating Lease, Liability, Statement of Financial Position [Extensible Enumeration]			us-gaap:OtherLiabilities
Operating lease discount rate			8.00%	10.00%
Operating lease, weighted average remaining lease term			2 years 9 months 18 days
Operating lease, cash payment made | $			$ 200,000	$ 300,000
Operating lease expense | $			$ 200,000	$ 300,000
Newton Lease
Lessee Lease Description [Line Items]
Lease expiration date			May 31, 2022
Newton Lease | Newton, Massachusetts
Lessee Lease Description [Line Items]
Lease agreement date			Mar. 06, 2018
Lease commencement date			Oct. 01, 2018
Square feet of office space leased								2,760
Additional Newton Lease
Lessee Lease Description [Line Items]
Lease expiration date		Dec. 31, 2022	Dec. 31, 2022
Additional Newton Lease | Newton, Massachusetts
Lessee Lease Description [Line Items]
Lease agreement date			Mar. 05, 2019
Lease commencement date			Jun. 01, 2019
Square feet of office space leased						1,600
Amendment of Newton Lease
Lessee Lease Description [Line Items]
Lease expiration date			Jun. 01, 2022
Reduced area of land			1,600
Amendment of Newton Lease | Newton, Massachusetts
Lessee Lease Description [Line Items]
Lease agreement date			Oct. 15, 2021
Bend Lease | Oregon
Lessee Lease Description [Line Items]
Lease agreement date			Apr. 01, 2018
Square feet of office space leased							2,288
Additional Bend Lease | Oregon
Lessee Lease Description [Line Items]
Lease agreement date			Apr. 23, 2019
Lease commencement date			May 01, 2019
Square feet of office space leased					1,389
Modified Bend Lease
Lessee Lease Description [Line Items]
Lease agreement date			Nov. 17, 2021
Lease expiration date	Jun. 30, 2022
Lease, existence of option to extend			true
Lease, option to extend			On November 17, 2021, the Company entered into a lease agreement to extend the term of the Bend Lease and the Additional Bend Lease to June 30, 2022 and to further extend the term either (1) until June 30, 2027 if FDA approval of OLPRUVATM was received in June 2022, or (2) until June 30, 2025 if FDA approval of OLPRUVATM was not received in June 2022. As FDA approval of OLPRUVATM was not received in June 2022, the Company entered into a lease amendment in June 2022 such that the renewal term for this office space was extended until June 30, 2025.
Lease renewal term for office space extended date			Jun. 30, 2025