<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001695434</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001069258</issuerCik>
      <issuerName>Kratos Defense &amp; Security Solutions Inc.</issuerName>
      <secFileNumber>001-34460</secFileNumber>
      <issuerAddress>
        <com:street1>1 Chisholm Trail</com:street1>
        <com:street2>STE 300</com:street2>
        <com:city>Round Rock </com:city>
        <com:stateOrCountry>TX</com:stateOrCountry>
        <com:zipCode>78681</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>5122389840</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Fendley Steven S.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Investments </name>
        <address>
          <com:street1>245 Summer St</com:street1>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02210</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>35000</noOfUnitsSold>
      <aggregateMarketValue>2176650.00</aggregateMarketValue>
      <noOfUnitsOutstanding>187519984</noOfUnitsOutstanding>
      <approxSaleDate>06/04/2026</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/04/2026</acquiredDate>
      <natureOfAcquisitionTransaction>Stock Award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>30326</amountOfSecuritiesAcquired>
      <paymentDate>03/04/2026</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/03/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Stock Award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>130</amountOfSecuritiesAcquired>
      <paymentDate>01/03/2025</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/04/2026</acquiredDate>
      <natureOfAcquisitionTransaction>Stock Award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>4544</amountOfSecuritiesAcquired>
      <paymentDate>01/04/2026</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>THE STEVEN FENDLEY REVOCABLE TR</name>
        <address>
          <com:street1>1 Chisholm Trail</com:street1>
          <com:city>Round Rock </com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78681</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>03/30/2026</saleDate>
      <amountOfSecuritiesSold>7000</amountOfSecuritiesSold>
      <grossProceeds>487114.93</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>THE STEVEN FENDLEY REVOCABLE TR</name>
        <address>
          <com:street1>1 Chisholm Trail,</com:street1>
          <com:city>Round Rock</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78681</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>04/27/2026</saleDate>
      <amountOfSecuritiesSold>7000</amountOfSecuritiesSold>
      <grossProceeds>431437.27</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>THE STEVEN FENDLEY REVOCABLE TR</name>
        <address>
          <com:street1>1 Chisholm Trail,</com:street1>
          <com:city>Round Rock</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78681</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>05/26/2026</saleDate>
      <amountOfSecuritiesSold>7000</amountOfSecuritiesSold>
      <grossProceeds>400678.81</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>06/04/2026</noticeDate>
      <signature>Jason Coleman as a duly authorized representative of National Financial Services LLC, as attorney-in-fact for STEVEN S FENDLEY TTEE</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
