X0202 4 2006-12-13 1 0001018952 KOS PHARMACEUTICALS INC KOSP 0001069006 NOVITCH MARK M D 3558 ALBERMARLE STREET, N.W. WASHINGTON DC 20008 1 0 0 0 Common Stock, $.01 Par Value 2006-12-13 4 U 0 7000 78 D 0 D Stock Option (Right to Buy) 11.16 2006-12-13 4 D 0 5000 0 D 2008-02-19 Common Stock 5000 0 D Stock Option (Right to Buy) 7.75 2006-12-13 4 D 0 3000 0 D 2008-03-12 Common Stock 3000 0 D Stock Option (Right to Buy) 7.14 2006-12-13 4 D 0 15000 0 D 2008-12-06 Common Stock 15000 0 D Stock Option (Right to Buy) 4.28 2006-12-13 4 D 0 15000 0 D 2009-03-11 Common Stock 15000 0 D Stock Option (Right to Buy) 4.97 2006-12-13 4 D 0 3000 0 D 2009-04-14 Common Stock 15000 0 D Stock Option (Right to Buy) 20.69 2006-12-13 4 D 0 15000 0 D 2010-03-11 Common Stock 15000 0 D Stock Option (Right to Buy) 13.81 2006-12-13 4 D 0 5000 0 D 2010-04-10 Common Stock 5000 0 D Stock Option (Right to Buy) 16.78 2006-12-13 4 D 0 20000 0 D 2011-03-11 Common Stock 20000 0 D Stock Option (Right to Buy) 17.94 2006-12-13 4 D 0 5000 0 D 2011-04-18 Common Stock 5000 0 D Stock Option (Right to Buy) 25.96 2006-12-13 4 D 0 20000 0 D 2012-03-11 Common Stock 20000 0 D Stock Option (Right to Buy) 24.24 2006-12-13 4 D 0 5000 0 D 2012-04-24 Common Stock 5000 0 D Stock Option (Right to Buy) 16.38 2006-12-13 4 D 0 30000 0 D 2013-03-11 Common Stock 30000 0 D Stock Option (Right to Buy) 20.9 2006-12-13 4 D 0 10000 0 D 2013-04-30 Common Stock 10000 0 D Stock Option (Right to Buy) 50.2 2006-12-13 4 D 0 10000 0 D 2014-01-28 Common Stock 10000 0 D Stock Option (Right to Buy) 43.5 2006-12-13 4 D 0 30000 0 D 2014-03-11 Common Stock 30000 0 D Stock Option (Right to Buy) 41.98 2006-12-13 4 D 0 10000 0 D 2014-04-28 Common Stock 10000 0 D Stock Option (Right to Buy) 32.01 2006-12-13 4 D 0 30000 0 D 2015-03-13 Common Stock 30000 0 D Stock Option (Right to Buy) 49.24 2006-12-13 4 D 0 10000 0 D 2015-04-27 Common Stock 10000 0 D Stock Option (Right to Buy) 46.24 2006-12-13 4 D 0 20000 0 D 2007-04-27 2013-04-26 Common Stock 20000 0 D Includes 5,000 restricted stock units. This option was canceled pursuant to the Agreement and Plan of Merger between the issuer and Abbott Laboratories in exchange for a cash payment in the amount $78.00 less the exercise price of the option. This option is currently exercisable. Juan F. Rodriguez, Attorney-in-Fact 2006-12-13