X0306 4 2021-12-31 0 0001068851 PROSPERITY BANCSHARES INC PB 0001077785 ZALMAN DAVID 4295 SAN FELIPE HOUSTON TX 77027-2915 1 1 0 0 Senior Chairman & CEO Common Stock 2021-12-31 4 A 0 2821 0.00 A 453234 D Common Stock 8938 I By Daughter Common Stock 351451 I By Children's Trust Common Stock 9531 I As Custodian for child Common Stock 8670 I As Custodian for child Common Stock 15774 I Through 401k Plan Includes 177 shares acquired through dividend reinvestment since the last filing by the reporting person. These shares are held in trust for the benefit of the reporting person's children. The reporting person's brother is trustee of the trust. The reporting person disclaims beneficial ownership of these securities, and the filing of this report is not an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose. Includes 188 shares acquired through dividend reinvestment since the last filing by the reporting person. Includes 302 shares acquired through the Prosperity Bancshares, Inc. 401(k) plan since the last filing by the reporting person. /s/ David Zalman 2022-01-04