<?xml version="1.0"?><ownershipDocument><schemaVersion>X0101</schemaVersion>    <documentType>4</documentType><periodOfReport>2003-06-30</periodOfReport><issuer><issuerCik>0001066745</issuerCik><issuerName>ESPERION THERAPEUTICS INC/MI</issuerName>        <issuerTradingSymbol>ESPR</issuerTradingSymbol></issuer><reportingOwner><reportingOwnerId><rptOwnerCik>0001242614</rptOwnerCik><rptOwnerName>KRAUSE BRIAN R</rptOwnerName></reportingOwnerId><reportingOwnerAddress><rptOwnerStreet1>  </rptOwnerStreet1><rptOwnerStreet2>  </rptOwnerStreet2><rptOwnerCity>  </rptOwnerCity><rptOwnerState>  </rptOwnerState><rptOwnerZipCode>  </rptOwnerZipCode></reportingOwnerAddress><reportingOwnerRelationship><isDirector>0</isDirector><isOfficer>1</isOfficer><isTenPercentOwner>0</isTenPercentOwner><isOther>0</isOther><officerTitle>VP Preclinical Res.&amp; Discovery</officerTitle><otherText></otherText></reportingOwnerRelationship></reportingOwner><nonDerivativeSecurity><securityTitle><value>Common Stock</value></securityTitle><transactionDate><value>2003-06-30</value></transactionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>J</transactionCode><equitySwapInvolved>0</equitySwapInvolved><footnoteId id="F1" /></transactionCoding><transactionTimeliness><value></value></transactionTimeliness><transactionAmounts><transactionShares><value>103</value></transactionShares><transactionValue><value>8.49</value></transactionValue><transactionAcquiredDisposedCode><value>A</value></transactionAcquiredDisposedCode></transactionAmounts><postTransactionAmounts><sharesOwnedFollowingTransaction><value>6299</value><footnoteId id="F2" /></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></nonDerivativeSecurity><footnotes><footnote id="F1">Purchased under Esperion Therapeutics, Inc. Employee Stock Purchase Plan</footnote><footnote id="F2">Indirect beneficial ownership of 500 shares as custodian for son and 500 shares as custodian for daughter</footnote></footnotes><ownerSignature><signatureName>Brian R. Krause</signatureName><signatureDate>2003-07-02</signatureDate></ownerSignature></ownershipDocument>

