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      <invstOrSec>
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        <lei>N/A</lei>
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      <invstOrSec>
        <name>Ultragenyx Pharmaceutical Inc</name>
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      <invstOrSec>
        <name>Praxis Precision Medicines Inc</name>
        <lei>N/A</lei>
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      <invstOrSec>
        <name>Insmed Inc</name>
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      <invstOrSec>
        <name>Arcus Biosciences Inc</name>
        <lei>N/A</lei>
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      <invstOrSec>
        <name>Arcutis Biotherapeutics Inc</name>
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      <invstOrSec>
        <name>Vir Biotechnology Inc</name>
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      <invstOrSec>
        <name>Vericel Corp</name>
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      <invstOrSec>
        <name>Altimmune Inc</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Cogent Biosciences Inc</name>
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        <name>Emergent BioSolutions Inc</name>
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        <name>Natera Inc</name>
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      <invstOrSec>
        <name>Neurocrine Biosciences Inc</name>
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        <name>Exelixis Inc</name>
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        <name>Verastem Inc</name>
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        <name>Crinetics Pharmaceuticals Inc</name>
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        <name>CG oncology Inc</name>
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        <name>Cytokinetics Inc</name>
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        <name>Nurix Therapeutics Inc</name>
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        <name>Summit Therapeutics Inc</name>
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        <name>Syndax Pharmaceuticals Inc</name>
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        <name>REGENXBIO Inc</name>
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        <name>Immunovant Inc</name>
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        <title>Immunovant Inc</title>
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          <isin value="US45258J1025"/>
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        <balance>1301964.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>20831424.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="12497963.10000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Day One Biopharmaceuticals Inc</name>
        <lei>N/A</lei>
        <title>Day One Biopharmaceuticals Inc</title>
        <cusip>23954D109</cusip>
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          <isin value="US23954D1090"/>
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        <balance>1206791.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>7844141.50000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="48750.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Soleno Therapeutics Inc</name>
        <lei>5493003LCY77N7FXK844</lei>
        <title>Soleno Therapeutics Inc</title>
        <cusip>834203309</cusip>
        <identifiers>
          <isin value="US8342033094"/>
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        <balance>579674.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>48565087.72000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Metsera Inc</name>
        <lei>N/A</lei>
        <title>Metsera Inc</title>
        <cusip>59267L107</cusip>
        <identifiers>
          <isin value="US59267L1070"/>
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        <balance>235937.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>6712407.65000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2991176.10000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alkermes PLC</name>
        <lei>N/A</lei>
        <title>Alkermes PLC</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="IE00B56GVS15"/>
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        <balance>1972254.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>56426186.94000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Amicus Therapeutics Inc</name>
        <lei>549300MRD1SMUTNBPQ53</lei>
        <title>Amicus Therapeutics Inc</title>
        <cusip>03152W109</cusip>
        <identifiers>
          <isin value="US03152W1099"/>
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        <balance>5075496.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>29082592.08000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>89bio Inc</name>
        <lei>N/A</lei>
        <title>89bio Inc</title>
        <cusip>282559103</cusip>
        <identifiers>
          <isin value="US2825591033"/>
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        <balance>1496343.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14694088.26000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Scholar Rock Holding Corp</name>
        <lei>549300Z1FLPGL4OWJ459</lei>
        <title>Scholar Rock Holding Corp</title>
        <cusip>80706P103</cusip>
        <identifiers>
          <isin value="US80706P1030"/>
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        <balance>1221204.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43255045.68000000</valUSD>
        <pctVal>0.895479077362</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PTC Therapeutics Inc</name>
        <lei>549300UJLWOIWFDGB318</lei>
        <title>PTC Therapeutics Inc</title>
        <cusip>69366J200</cusip>
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          <isin value="US69366J2006"/>
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        <balance>1193980.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>58313983.20000000</valUSD>
        <pctVal>1.207233770127</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Capricor Therapeutics Inc</name>
        <lei>5493002ZI5PDLXV4DX14</lei>
        <title>Capricor Therapeutics Inc</title>
        <cusip>14070B309</cusip>
        <identifiers>
          <isin value="US14070B3096"/>
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        <balance>586331.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5822266.83000000</valUSD>
        <pctVal>0.120534334136</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="6132460.18000000"/>
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      </invstOrSec>
      <invstOrSec>
        <name>Novavax Inc</name>
        <lei>529900J4GJHPEPQ23205</lei>
        <title>Novavax Inc</title>
        <cusip>670002401</cusip>
        <identifiers>
          <isin value="US6700024010"/>
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        <balance>3106411.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19570389.30000000</valUSD>
        <pctVal>0.405152136091</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="18511245.20000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SpringWorks Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>SpringWorks Therapeutics Inc</title>
        <cusip>85205L107</cusip>
        <identifiers>
          <isin value="US85205L1070"/>
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        <balance>1394246.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>65515619.54000000</valUSD>
        <pctVal>1.356324230300</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>uniQure NV</name>
        <lei>724500RPCTZLFYJZ3S98</lei>
        <title>uniQure NV</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="NL0010696654"/>
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        <balance>841297.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11727680.18000000</valUSD>
        <pctVal>0.242789992753</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4444699.92000000"/>
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      </invstOrSec>
      <invstOrSec>
        <name>Mirum Pharmaceuticals Inc</name>
        <lei>254900YZKR40F7F27K81</lei>
        <title>Mirum Pharmaceuticals Inc</title>
        <cusip>604749101</cusip>
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          <isin value="US6047491013"/>
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        <balance>454856.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>23147621.84000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Roivant Sciences Ltd</name>
        <lei>549300DL466NY5J6U724</lei>
        <title>Roivant Sciences Ltd</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="BMG762791017"/>
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        <balance>7226000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>81437020.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BM</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="52905201.64000000"/>
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      </invstOrSec>
      <invstOrSec>
        <name>ARS Pharmaceuticals Inc</name>
        <lei>N/A</lei>
        <title>ARS Pharmaceuticals Inc</title>
        <cusip>82835W108</cusip>
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          <isin value="US82835W1080"/>
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        <balance>988683.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1959216.20000000"/>
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      </invstOrSec>
      <invstOrSec>
        <name>Xencor Inc</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>Xencor Inc</title>
        <cusip>98401F105</cusip>
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          <isin value="US98401F1057"/>
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        <balance>1107974.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>8708675.64000000</valUSD>
        <pctVal>0.180289644931</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Gilead Sciences Inc</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>Gilead Sciences Inc</title>
        <cusip>375558103</cusip>
        <identifiers>
          <isin value="US3755581036"/>
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        <balance>1075615.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>119253435.05000000</valUSD>
        <pctVal>2.468820788699</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Janux Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Janux Therapeutics Inc</title>
        <cusip>47103J105</cusip>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>MannKind Corp</name>
        <lei>213800GFBCNY1ZFST722</lei>
        <title>MannKind Corp</title>
        <cusip>56400P706</cusip>
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          <isin value="US56400P7069"/>
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        <curCd>USD</curCd>
        <valUSD>10761924.80000000</valUSD>
        <pctVal>0.222796631908</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>



    </explntrNotes>
    <signature>
      <ncom:dateSigned>2025-07-29</ncom:dateSigned>
      <ncom:nameOfApplicant>SPDR SERIES TRUST</ncom:nameOfApplicant>
      <ncom:signature>Arthur Jensen</ncom:signature>
      <ncom:signerName>Arthur Jensen</ncom:signerName>
      <ncom:title>Deputy Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
