NPORT-P false 0001064642 XXXXXXXX S000010018 C000027706 SPDR SERIES TRUST 811-08839 0001064642 5493004JVD6CQEEJSS37 One Iron Street Boston 02210 617-664-8594 SPDR(R) S&P(R) Biotech ETF S000010018 549300Y3ODFMPD5XXL58 2024-06-30 2023-09-30 N 6051984054.77 555023846.50 5496960208.27 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 UST Ionis Pharmaceuticals Inc 549300SI4ZGLG0BLUZ92 462222100 1726604.00000000 NS USD 78318757.44000000 1.424764860443 Long EC CORP US N 1 N N MiMedx Group Inc N/A 602496101 1802459.00000000 NS USD 13139926.11000000 0.239039862253 Long EC CORP US N 1 N N N Arrowhead Pharmaceuticals Inc 549300O3CSB8T7OZ3D66 04280A100 2379432.00000000 NS USD 63935337.84000000 1.163103522994 Long EC CORP US N 1 N N N Protagonist Therapeutics Inc N/A 74366E102 2811338.00000000 NS USD 46893117.84000000 0.853073627301 Long EC CORP US N 1 N N Rhythm Pharmaceuticals Inc 529900JPNWXQ8DPLA551 76243J105 1306961.00000000 NS USD 29962080.93000000 0.545066360220 Long EC CORP US N 1 N N Alnylam Pharmaceuticals Inc 529900S3ZI14OWRJII50 02043Q107 353123.00000000 NS USD 62538083.30000000 1.137684846361 Long EC CORP US N 1 N N N Anavex Life Sciences Corp 549300K1I5L8COCQ8W36 032797300 2173427.00000000 NS USD 14235946.85000000 0.258978531963 Long EC CORP US N 1 N N Vera Therapeutics Inc N/A 92337R101 1095095.00000000 NS USD 15013752.45000000 0.273128272375 Long EC CORP US N 1 N N N Relay Therapeutics Inc N/A 75943R102 3032091.00000000 NS USD 25499885.31000000 0.463890665819 Long EC CORP US N 1 N N Kura Oncology Inc 5493005QORQTZCZYOP39 50127T109 1863981.00000000 NS USD 16999506.72000000 0.309252861143 Long EC CORP US N 1 N N Vertex Pharmaceuticals Inc 54930015RAQRRZ5ZGJ91 92532F100 207394.00000000 NS USD 72119189.56000000 1.311983111165 Long EC CORP US N 1 N N N BioCryst Pharmaceuticals Inc 549300Z0INP1Z5NP6J59 09058V103 6484696.00000000 NS USD 45911647.68000000 0.835218847153 Long EC CORP US N 1 N N Exact Sciences Corp 549300VM3X1FYD4N9Z14 30063P105 908269.00000000 NS USD 61962111.18000000 1.127206834911 Long EC CORP US N 1 N N N Intercept Pharmaceuticals Inc 254900JMB8TX5P688V24 45845P108 2457799.00000000 NS USD 45567593.46000000 0.828959856603 Long EC CORP US N 1 N N Caribou Biosciences Inc N/A 142038108 4024590.00000000 NS USD 19237540.20000000 0.349966881169 Long EC CORP US N 1 N N Verve Therapeutics Inc N/A 92539P101 2249812.00000000 NS USD 29832507.12000000 0.542709169972 Long EC CORP US N 1 N N Keros Therapeutics Inc N/A 492327101 466643.00000000 NS USD 14876578.84000000 0.270632827532 Long EC CORP US N 1 N N Catalyst Pharmaceuticals Inc 5299004O0R5XXLA5H544 14888U101 4097391.00000000 NS USD 47898500.79000000 0.871363425879 Long EC CORP US N 1 N N N AbbVie Inc FR5LCKFTG8054YNNRU85 00287Y109 477526.00000000 NS USD 71180025.56000000 1.294897959292 Long EC CORP US N 1 N N N Myriad Genetics Inc 52990044IHUOUMETT163 62855J104 1673483.00000000 NS USD 26842667.32000000 0.488318385125 Long EC CORP US N 1 N N N Cabaletta Bio Inc N/A 12674W109 948017.00000000 NS USD 14428818.74000000 0.262487232821 Long EC CORP US N 1 N N N Lyell Immunopharma Inc N/A 55083R104 3411027.00000000 NS USD 5014209.69000000 0.091217864056 Long EC CORP US N 1 N N Dyne Therapeutics Inc N/A 26818M108 1119228.00000000 NS USD 10028282.88000000 0.182433244921 Long EC CORP US N 1 N N N Avid Bioservices Inc 549300GRUS3ZMGP8MX22 05368M106 1555869.00000000 NS USD 14687403.36000000 0.267191371294 Long EC CORP US N 1 N N BioMarin Pharmaceutical Inc NSLL8ITTRR0J5HEMR848 09061G101 788823.00000000 NS USD 69795059.04000000 1.269702824753 Long EC CORP US N 1 N N N Geron Corp 549300T282D7Z2YESL90 374163103 15268862.00000000 NS USD 32369987.44000000 0.588870688772 Long EC CORP US N 1 N N Viridian Therapeutics Inc 549300C775BNYF550E70 92790C104 2105418.00000000 NS USD 32297112.12000000 0.587544950232 Long EC CORP US N 1 N N Sage Therapeutics Inc 5493000JX4BJS9W6CN35 78667J108 3292234.00000000 NS USD 67754175.72000000 1.232575335329 Long EC CORP US N 1 N N OMNIAB INC N/A 68218J301 161959.00000000 NS USD 0.00000000 0.000000 Long EC CORP US N 3 N N Beam Therapeutics Inc N/A 07373V105 2718043.00000000 NS USD 65368934.15000000 1.189183324479 Long EC CORP US N 1 N N Seres Therapeutics Inc 549300GMXBE5NUWISF13 81750R102 7515914.00000000 NS USD 17887875.32000000 0.325413949569 Long EC CORP US N 1 N N Travere Therapeutics Inc N/A 89422G107 2906067.00000000 NS USD 25980238.98000000 0.472629198605 Long EC CORP US N 1 N N AnaptysBio Inc 529900HH4WQT03IG1A12 032724106 500335.00000000 NS USD 8986016.60000000 0.163472469501 Long EC CORP US N 1 N N N Horizon Therapeutics Plc 529900P0GSQ79OOZEV53 000000000 616362.00000000 NS USD 71306919.78000000 1.297206402780 Long EC CORP IE N 1 N N N Seagen Inc N/A 81181C104 348008.00000000 NS USD 73829897.20000000 1.343104086671 Long EC CORP US N 1 N N N Alector Inc 549300Z8RQOIY1JMHC25 014442107 1498270.00000000 NS USD 9708789.60000000 0.176621063863 Long EC CORP US N 1 N N Agios Pharmaceuticals Inc 529900ONJHY8EOGYT555 00847X104 1072741.00000000 NS USD 26550339.75000000 0.483000399203 Long EC CORP US N 1 N N Arcturus Therapeutics Holdings Inc N/A 03969T109 1066115.00000000 NS USD 27239238.25000000 0.495532752975 Long EC CORP US N 1 N N Intellia Therapeutics Inc 5493002T5BCPE5DZC723 45826J105 1878548.00000000 NS USD 59399687.76000000 1.080591554412 Long EC CORP US N 1 N N Point Biopharma Global Inc N/A 730541109 1791221.00000000 NS USD 11947444.07000000 0.217346380860 Long EC CORP US N 1 N N Halozyme Therapeutics Inc 529900242I3SV9AGM753 40637H109 1847658.00000000 NS USD 70580535.60000000 1.283992114292 Long EC CORP US N 1 N N Bluebird Bio Inc N/A 09609G100 10466651.00000000 NS USD 31818619.04000000 0.578840265063 Long EC CORP US N 1 N N Apellis Pharmaceuticals Inc 254900HS0ZFRXXSB9D42 03753U106 1711330.00000000 NS USD 65098993.20000000 1.184272593097 Long EC CORP US N 1 N N Biogen Inc W8J5WZB5IY3K0NDQT671 09062X103 274707.00000000 NS USD 70602446.07000000 1.284390706772 Long EC CORP US N 1 N N N Madrigal Pharmaceuticals Inc 549300CHIMT2EUSNJB60 558868105 361812.00000000 NS USD 52839024.48000000 0.961240803608 Long EC CORP US N 1 N N Ironwood Pharmaceuticals Inc 549300PC8MR6QHH6P296 46333X108 6983080.00000000 NS USD 67247060.40000000 1.223349958015 Long EC CORP US N 1 N N United Therapeutics Corp 5299005C4HZL4UWROC14 91307C102 316010.00000000 NS USD 71377178.70000000 1.298484544105 Long EC CORP US N 1 N N N ACADIA Pharmaceuticals Inc 529900O3044NO0PEA039 004225108 2689619.00000000 NS USD 56051659.96000000 1.019684659089 Long EC CORP US N 1 N N N Viking Therapeutics Inc 529900IVC72YPFA25M37 92686J106 4477024.00000000 NS USD 49560655.68000000 0.901601135941 Long EC CORP US N 1 N N REVOLUTION Medicines Inc 549300JU3X0LBCQ65892 76155X100 1812720.00000000 NS USD 50176089.60000000 0.912797031430 Long EC CORP US N 1 N N N Moderna Inc 549300EI6OKH5K5Q2G38 60770K107 661077.00000000 NS USD 68282643.33000000 1.242189150783 Long EC CORP US N 1 N N N Biohaven Ltd N/A 000000000 2751422.00000000 NS USD 71564486.22000000 1.301892018653 Long EC CORP VG N 1 N N N Iovance Biotherapeutics Inc 2549002L8WT2ACU5Q878 462260100 11955172.00000000 NS USD 54396032.60000000 0.989565697022 Long EC CORP US N 1 N N Recursion Pharmaceuticals Inc N/A 75629V104 8828224.00000000 NS USD 67535913.60000000 1.228604738640 Long EC CORP US N 1 N N Celldex Therapeutics Inc 529900F018DMYWH38923 15117B202 1322817.00000000 NS USD 36403923.84000000 0.662255545987 Long EC CORP US N 1 N N ImmunoGen Inc 54930084U0R1OP766Y02 45253H101 4531725.00000000 NS USD 71918475.75000000 1.308331751097 Long EC CORP US N 1 N N N Twist Bioscience Corp 549300T23BL59LCOH584 90184D100 2720499.00000000 NS USD 55117309.74000000 1.002687078889 Long EC CORP US N 1 N N CRISPR Therapeutics AG 506700O6IRRIQLT3W370 000000000 1424671.00000000 NS USD 64665816.69000000 1.176392301197 Long EC CORP CH N 1 N N Disc Medicine Inc N/A 254604101 500983.00000000 NS USD 23536181.34000000 0.428167213300 Long EC CORP US N 1 N N Denali Therapeutics Inc 549300ZTQ2HO18L3Q830 24823R105 1841113.00000000 NS USD 37982161.19000000 0.690966638849 Long EC CORP US N 1 N N N Kiniksa Pharmaceuticals Ltd N/A 000000000 1116695.00000000 NS USD 19396992.15000000 0.352867610735 Long EC CORP BM N 1 N N Mirati Therapeutics Inc 529900GYRW59IDQV6N54 60468T105 1994965.00000000 NS USD 86900675.40000000 1.580886018953 Long EC CORP US N 1 N N Sana Biotechnology Inc N/A 799566104 2607727.00000000 NS USD 10091903.49000000 0.183590622955 Long EC CORP US N 1 N N Akero Therapeutics Inc 549300SI3KG74LBE2955 00973Y108 1467193.00000000 NS USD 74210621.94000000 1.350030182651 Long EC CORP US N 1 N N N Cerevel Therapeutics Holdings Inc 254900RJNIRS9COSQR41 15678U128 1597547.00000000 NS USD 34874451.01000000 0.634431571062 Long EC CORP US N 1 N N Incyte Corp 549300Z4WN6JVZ3T4680 45337C102 1111969.00000000 NS USD 64238449.13000000 1.168617684977 Long EC CORP US N 1 N N N Krystal Biotech Inc 549300YONUY68210OE41 501147102 573581.00000000 NS USD 66535396.00000000 1.210403449890 Long EC CORP US N 1 N N ADMA Biologics Inc N/A 000899104 5020736.00000000 NS USD 17974234.88000000 0.326984991686 Long EC CORP US N 1 N N N State Street Global Advisors 5493008BJIBKQ5KTIF74 857492706 462959813.00000000 NS USD 462959813.00000000 8.422105954187 Long STIV RF US N 1 N N Amgen Inc 62QBXGPJ34PQ72Z12S66 031162100 274231.00000000 NS USD 73702323.56000000 1.340783283261 Long EC CORP US N 1 N N N Ideaya Biosciences Inc 549300ULW08F62IJML11 45166A102 1036146.00000000 NS USD 27955219.08000000 0.508557785045 Long EC CORP US N 1 N N Karuna Therapeutics Inc N/A 48576A100 386151.00000000 NS USD 65294272.59000000 1.187825090888 Long EC CORP US N 1 N N N Avidity Biosciences Inc N/A 05370A108 2650972.00000000 NS USD 16913201.36000000 0.307682805026 Long EC CORP US N 1 N N Replimune Group Inc 549300AY704NEIRC4K64 76029N106 1499809.00000000 NS USD 25661731.99000000 0.466834960009 Long EC CORP US N 1 N N Veracyte Inc 529900ESWZRHXOW27Z37 92337F107 1705341.00000000 NS USD 38080264.53000000 0.692751322316 Long EC CORP US N 1 N N N Vaxcyte Inc 254900M7NMHTGASX8D95 92243G108 1309301.00000000 NS USD 66748164.98000000 1.214274116075 Long EC CORP US N 1 N N Blueprint Medicines Corp 5299004CC60O9T5HVM83 09627Y109 1332463.00000000 NS USD 66916291.86000000 1.217332658863 Long EC CORP US N 1 N N N Morphic Holding Inc 549300RWWOUFLHTY1224 61775R105 1111356.00000000 NS USD 25461165.96000000 0.463186288336 Long EC CORP US N 1 N N CareDx Inc 549300NQOFKL9NON0U06 14167L103 2450651.00000000 NS USD 17154557.00000000 0.312073516089 Long EC CORP US N 1 N N Bridgebio Pharma Inc 54930028YG89VTY2J114 10806X102 2504507.00000000 NS USD 66043849.59000000 1.201461300204 Long EC CORP US N 1 N N N Prothena Corp PLC 5299009ZXQ8NIIJ8OL30 000000000 1253727.00000000 NS USD 60492327.75000000 1.100468721949 Long EC CORP IE N 1 N N Nuvalent Inc N/A 670703107 767947.00000000 NS USD 35302523.59000000 0.642219012917 Long EC CORP US N 1 N N Kymera Therapeutics Inc N/A 501575104 1205124.00000000 NS USD 16751223.60000000 0.304736126246 Long EC CORP US N 1 N N Dynavax Technologies Corp 549300T5URIXWDILX594 268158201 3826009.00000000 NS USD 56510152.93000000 1.028025504805 Long EC CORP US N 1 N N Deciphera Pharmaceuticals Inc 529900QR4WAPYY0CBF25 24344T101 1121802.00000000 NS USD 14269321.44000000 0.259585678254 Long EC CORP US N 1 N N N Arcellx Inc N/A 03940C100 1274509.00000000 NS USD 45729382.92000000 0.831903109853 Long EC CORP US N 1 N N N Scilex Holding Co N/A 80880W106 5938074.00000000 NS USD 8313303.60000000 0.151234560284 Long EC CORP US N 1 N N N iTeos Therapeutics Inc N/A 46565G104 683276.00000000 NS USD 7481872.20000000 0.136109266149 Long EC CORP US N 1 N N N Ardelyx Inc 549300F542QR4SXHCY32 039697107 8812252.00000000 NS USD 35953988.16000000 0.654070373402 Long EC CORP US N 1 N N TG Therapeutics Inc 529900X21UKABN9NJ529 88322Q108 6847525.00000000 NS USD 57245309.00000000 1.041399370398 Long EC CORP US N 1 N N ACELYRIN Inc N/A 00445A100 1394736.00000000 NS USD 14184465.12000000 0.258041982888 Long EC CORP US N 1 N N N Sarepta Therapeutics Inc 549300IKDPIED8J8IG21 803607100 593326.00000000 NS USD 71922977.72000000 1.308413650362 Long EC CORP US N 1 N N N Biomea Fusion Inc N/A 09077A106 1876816.00000000 NS USD 25824988.16000000 0.469804895461 Long EC CORP US N 1 N N Aldeyra Therapeutics Inc 529900HGKY864E4Y9014 01438T106 2156928.00000000 NS USD 14408279.04000000 0.262113577215 Long EC CORP US N 1 N N ACHILLION PHARMACE 529900LZPJ796VSWZM38 004CVR031 51865.00000000 NS USD 75463.58000000 0.001372823836 N/A DE US N 2 N/A N/A Achillion Pharmaceuticals Inc Achillion Pharmaceuticals Inc 2024-07-29 XXXX 51605.68000000 N N OMNIAB INC N/A 68218J202 161959.00000000 NS USD 0.00000000 0.000000 Long EC CORP US N 3 N N Prime Medicine Inc N/A 74168J101 1034455.00000000 NS USD 9868700.70000000 0.179530146227 Long EC CORP US N 1 N N Ultragenyx Pharmaceutical Inc 529900EV44GVDN1DCX77 90400D108 1469486.00000000 NS USD 52387175.90000000 0.953020831789 Long EC CORP US N 1 N N Insmed Inc 529900Q55QAG41CCAC11 457669307 2184915.00000000 NS USD 55169103.75000000 1.003629308922 Long EC CORP US N 1 N N RAPT Therapeutics Inc 549300MB473BIU78ES48 75382E109 787586.00000000 NS USD 13089679.32000000 0.238125779049 Long EC CORP US N 1 N N Arcus Biosciences Inc N/A 03969F109 2350007.00000000 NS USD 42182625.65000000 0.767380953322 Long EC CORP US N 1 N N Arcutis Biotherapeutics Inc N/A 03969K108 3365127.00000000 NS USD 17868824.37000000 0.325067377113 Long EC CORP US N 1 N N Vir Biotechnology Inc N/A 92764N102 4216416.00000000 NS USD 39507817.92000000 0.718721191769 Long EC CORP US N 1 N N Vericel Corp 54930076YM3PLTDR4B91 92346J108 1005289.00000000 NS USD 33697287.28000000 0.613016758413 Long EC CORP US N 1 N N Cogent Biosciences Inc N/A 19240Q201 1539393.00000000 NS USD 15009081.75000000 0.273043303595 Long EC CORP US N 1 N N Natera Inc N/A 632307104 1312605.00000000 NS USD 58082771.25000000 1.056634376989 Long EC CORP US N 1 N N N Neurocrine Biosciences Inc 549300FECER0XBN49756 64125C109 651161.00000000 NS USD 73255612.50000000 1.332656772552 Long EC CORP US N 1 N N N Exelixis Inc 254900PJQB59O2O95R37 30161Q104 3217939.00000000 NS USD 70311967.15000000 1.279106351256 Long EC CORP US N 1 N N N Editas Medicine Inc 5299000AON4Q9NT2JE42 28106W103 3977779.00000000 NS USD 31026676.20000000 0.564433341782 Long EC CORP US N 1 N N Crinetics Pharmaceuticals Inc 549300Q1CNFXK5P31D28 22663K107 1586864.00000000 NS USD 47193335.36000000 0.858535146188 Long EC CORP US N 1 N N N Cytokinetics Inc 549300BE5DY1HW7IHA64 23282W605 1972933.00000000 NS USD 58122606.18000000 1.057359048962 Long EC CORP US N 1 N N Inhibrx Inc 549300VBKG2LTV1TLY22 45720L107 929890.00000000 NS USD 17063481.50000000 0.310416682193 Long EC CORP US N 1 N N Regeneron Pharmaceuticals Inc 549300RCBFWIRX3HYQ56 75886F107 85613.00000000 NS USD 70456074.48000000 1.281727933449 Long EC CORP US N 1 N N N Nurix Therapeutics Inc N/A 67080M103 793276.00000000 NS USD 6235149.36000000 0.113429043030 Long EC CORP US N 1 N N Syndax Pharmaceuticals Inc 529900OF94TRHKZVBS87 87164F105 2280572.00000000 NS USD 33113905.44000000 0.602403950281 Long EC CORP US N 1 N N N REGENXBIO Inc 549300EOES47LATSET33 75901B107 1058198.00000000 NS USD 17417939.08000000 0.316864929343 Long EC CORP US N 1 N N Immunovant Inc N/A 45258J102 2382223.00000000 NS USD 91453540.97000000 1.663711169537 Long EC CORP US N 1 N N N Day One Biopharmaceuticals Inc N/A 23954D109 1902696.00000000 NS USD 23346079.92000000 0.424708912479 Long EC CORP US N 1 N N Rocket Pharmaceuticals Inc 549300R7VV82YUIN4Y93 77313F106 1939598.00000000 NS USD 39742363.02000000 0.722988006356 Long EC CORP US N 1 N N N EQRx Inc N/A 26886C107 4194716.00000000 NS USD 9312269.52000000 0.169407621070 Long EC CORP US N 1 N N N Coherus Biosciences Inc 5493007IL8W5MV932D26 19249H103 6960676.00000000 NS USD 26032928.24000000 0.473587714912 Long EC CORP US N 1 N N Alkermes PLC N/A 000000000 2466286.00000000 NS USD 69080670.86000000 1.256706765969 Long EC CORP IE N 1 N N N Amicus Therapeutics Inc 549300MRD1SMUTNBPQ53 03152W109 5660549.00000000 NS USD 68832275.84000000 1.252187995402 Long EC CORP US N 1 N N N 89bio Inc N/A 282559103 3066136.00000000 NS USD 47341139.84000000 0.861223986463 Long EC CORP US N 1 N N PTC Therapeutics Inc 549300UJLWOIWFDGB318 69366J200 1656239.00000000 NS USD 37116315.99000000 0.675215293248 Long EC CORP US N 1 N N N Novavax Inc 529900J4GJHPEPQ23205 670002401 7929702.00000000 NS USD 57411042.48000000 1.044414372758 Long EC CORP US N 1 N N SpringWorks Therapeutics Inc N/A 85205L107 1441611.00000000 NS USD 33330046.32000000 0.606335957641 Long EC CORP US N 1 N N uniQure NV 724500RPCTZLFYJZ3S98 000000000 3137103.00000000 NS USD 21049961.13000000 0.382938211892 Long EC CORP NL N 1 N N 4D Molecular Therapeutics Inc N/A 35104E100 988822.00000000 NS USD 12587704.06000000 0.228993909052 Long EC CORP US N 1 N N Mirum Pharmaceuticals Inc 254900YZKR40F7F27K81 604749101 1101592.00000000 NS USD 34810307.20000000 0.633264675040 Long EC CORP US N 1 N N Roivant Sciences Ltd 549300DL466NY5J6U724 000000000 5645605.00000000 NS USD 65940666.40000000 1.199584204753 Long EC CORP BM N 1 N N Xencor Inc 549300V5IF65437JKG30 98401F105 888975.00000000 NS USD 17912846.25000000 0.325868217547 Long EC CORP US N 1 N N Allogene Therapeutics Inc N/A 019770106 6301470.00000000 NS USD 19975659.90000000 0.363394660742 Long EC CORP US N 1 N N State Street Global Advisors 5493000HFJPORCLSV250 85749P101 3658218.88000000 NS USD 3658950.52000000 0.066563161845 Long STIV RF US N 1 N N N Agenus Inc 529900NDQQGU5H4UJK81 00847G705 13492714.00000000 NS USD 15246766.82000000 0.277367240116 Long EC CORP US N 1 N N Gilead Sciences Inc 549300WTZWR07K8MNV44 375558103 936170.00000000 NS USD 70156579.80000000 1.276279564375 Long EC CORP US N 1 N N N MannKind Corp 213800GFBCNY1ZFST722 56400P706 6868832.00000000 NS USD 28368276.16000000 0.516072066836 Long EC CORP US N 1 N N Zentalis Pharmaceuticals Inc N/A 98943L107 1610556.00000000 NS USD 32307753.36000000 0.587738534315 Long EC CORP US N 1 N N 2023-10-27 SPDR SERIES TRUST Arthur Jensen Arthur Jensen Deputy Treasurer XXXX