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        <name>Avid Bioservices Inc</name>
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        <name>Chinook Therapeutics Inc</name>
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        <name>BioMarin Pharmaceutical Inc</name>
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        <name>Geron Corp</name>
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      <invstOrSec>
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      <invstOrSec>
        <name>Sana Biotechnology Inc</name>
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      <invstOrSec>
        <name>Akero Therapeutics Inc</name>
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        <name>Cerevel Therapeutics Holdings Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Incyte Corp</name>
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      <invstOrSec>
        <name>Krystal Biotech Inc</name>
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        <name>ADMA Biologics Inc</name>
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        <name>State Street Global Advisors</name>
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        <name>Amgen Inc</name>
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      <invstOrSec>
        <name>Ideaya Biosciences Inc</name>
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        <name>Karuna Therapeutics Inc</name>
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        <name>Avidity Biosciences Inc</name>
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        <name>Allakos Inc</name>
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        <name>Replimune Group Inc</name>
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        <name>Veracyte Inc</name>
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        <name>Vaxcyte Inc</name>
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        <name>Blueprint Medicines Corp</name>
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        <name>Morphic Holding Inc</name>
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        <name>Bridgebio Pharma Inc</name>
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        <name>Nuvalent Inc</name>
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        <name>Natera Inc</name>
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        <name>Editas Medicine Inc</name>
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        <name>Inhibrx Inc</name>
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      <invstOrSec>
        <name>Nurix Therapeutics Inc</name>
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        <name>Syndax Pharmaceuticals Inc</name>
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        <name>REGENXBIO Inc</name>
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        <name>uniQure NV</name>
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      <invstOrSec>
        <name>Mirum Pharmaceuticals Inc</name>
        <lei>254900YZKR40F7F27K81</lei>
        <title>Mirum Pharmaceuticals Inc</title>
        <cusip>604749101</cusip>
        <identifiers>
          <isin value="US6047491013"/>
        </identifiers>
        <balance>1000529.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>25883685.23000000</valUSD>
        <pctVal>0.397830408083</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="6242746.93000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Roivant Sciences Ltd</name>
        <lei>549300DL466NY5J6U724</lei>
        <title>Roivant Sciences Ltd</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="BMG762791017"/>
        </identifiers>
        <balance>6215865.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>62655919.20000000</valUSD>
        <pctVal>0.963017038829</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BM</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="25066603.44000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Xencor Inc</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>Xencor Inc</title>
        <cusip>98401F105</cusip>
        <identifiers>
          <isin value="US98401F1057"/>
        </identifiers>
        <balance>1026767.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>25638371.99000000</valUSD>
        <pctVal>0.394059960965</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4953519.75000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Allogene Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Allogene Therapeutics Inc</title>
        <cusip>019770106</cusip>
        <identifiers>
          <isin value="US0197701065"/>
        </identifiers>
        <balance>6590849.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>32756519.53000000</valUSD>
        <pctVal>0.503465384323</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="21252319.08000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>State Street Global Advisors</name>
        <lei>5493000HFJPORCLSV250</lei>
        <title>State Street Institutional Liquid Reserves Fund</title>
        <cusip>85749P101</cusip>
        <identifiers>
          <isin value="US85749P1012"/>
        </identifiers>
        <balance>2170347.97000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2170782.05000000</valUSD>
        <pctVal>0.033364766305</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Agenus Inc</name>
        <lei>529900NDQQGU5H4UJK81</lei>
        <title>Agenus Inc</title>
        <cusip>00847G705</cusip>
        <identifiers>
          <isin value="US00847G7051"/>
        </identifiers>
        <balance>12409731.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19855569.60000000</valUSD>
        <pctVal>0.305178697952</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="366261.20000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Gilead Sciences Inc</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>Gilead Sciences Inc</title>
        <cusip>375558103</cusip>
        <identifiers>
          <isin value="US3755581036"/>
        </identifiers>
        <balance>917743.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>70730453.01000000</valUSD>
        <pctVal>1.087122051395</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MannKind Corp</name>
        <lei>213800GFBCNY1ZFST722</lei>
        <title>MannKind Corp</title>
        <cusip>56400P706</cusip>
        <identifiers>
          <isin value="US56400P7069"/>
        </identifiers>
        <balance>10221617.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>41601981.19000000</valUSD>
        <pctVal>0.639419503321</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="9599230.08000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zentalis Pharmaceuticals Inc</name>
        <lei>N/A</lei>
        <title>Zentalis Pharmaceuticals Inc</title>
        <cusip>98943L107</cusip>
        <identifiers>
          <isin value="US98943L1070"/>
        </identifiers>
        <balance>2165532.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>61089657.72000000</valUSD>
        <pctVal>0.938943710854</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="31989763.01000000"/>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>



    </explntrNotes>
    <signature>
      <ncom:dateSigned>2023-07-25</ncom:dateSigned>
      <ncom:nameOfApplicant>SPDR SERIES TRUST</ncom:nameOfApplicant>
      <ncom:signature>Arthur Jensen</ncom:signature>
      <ncom:signerName>Arthur Jensen</ncom:signerName>
      <ncom:title>Deputy Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
