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        <name>Geron Corp</name>
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        <name>Seagen Inc</name>
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        <name>Alector Inc</name>
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        <name>Arcturus Therapeutics Holdings Inc</name>
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        <name>Biohaven Ltd</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Altimmune Inc</name>
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      <invstOrSec>
        <name>Cogent Biosciences Inc</name>
        <lei>N/A</lei>
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        <name>Emergent BioSolutions Inc</name>
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        <name>Natera Inc</name>
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      <invstOrSec>
        <name>Neurocrine Biosciences Inc</name>
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        <name>Exelixis Inc</name>
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      <invstOrSec>
        <name>Editas Medicine Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Crinetics Pharmaceuticals Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Cytokinetics Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Inhibrx Inc</name>
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        <name>Regeneron Pharmaceuticals Inc</name>
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        <name>Nurix Therapeutics Inc</name>
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        <name>Syndax Pharmaceuticals Inc</name>
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        <name>REGENXBIO Inc</name>
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        <name>Immunovant Inc</name>
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        <name>Day One Biopharmaceuticals Inc</name>
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        <name>Rocket Pharmaceuticals Inc</name>
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        <name>Coherus Biosciences Inc</name>
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        <name>Alkermes PLC</name>
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        <name>89bio Inc</name>
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        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PTC Therapeutics Inc</name>
        <lei>549300UJLWOIWFDGB318</lei>
        <title>PTC Therapeutics Inc</title>
        <cusip>69366J200</cusip>
        <identifiers>
          <isin value="US69366J2006"/>
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        <balance>1426056.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>69078152.64000000</valUSD>
        <pctVal>1.066695449916</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Novavax Inc</name>
        <lei>529900J4GJHPEPQ23205</lei>
        <title>Novavax Inc</title>
        <cusip>670002401</cusip>
        <identifiers>
          <isin value="US6700024010"/>
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        <balance>9674292.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>67042843.56000000</valUSD>
        <pctVal>1.035266483566</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="26895331.66000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Karyopharm Therapeutics Inc</name>
        <lei>549300J1VANRCNTYST87</lei>
        <title>Karyopharm Therapeutics Inc</title>
        <cusip>48576U106</cusip>
        <identifiers>
          <isin value="US48576U1060"/>
        </identifiers>
        <balance>8468629.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>32942966.81000000</valUSD>
        <pctVal>0.508700818710</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="6962469.82000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SpringWorks Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>SpringWorks Therapeutics Inc</title>
        <cusip>85205L107</cusip>
        <identifiers>
          <isin value="US85205L1070"/>
        </identifiers>
        <balance>2028830.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>52222084.20000000</valUSD>
        <pctVal>0.806406330690</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="23948452.61000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>uniQure NV</name>
        <lei>724500RPCTZLFYJZ3S98</lei>
        <title>uniQure NV</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="NL0010696654"/>
        </identifiers>
        <balance>2000073.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>40281470.22000000</valUSD>
        <pctVal>0.622020991550</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4764955.70000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>4D Molecular Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>4D Molecular Therapeutics Inc</title>
        <cusip>35104E100</cusip>
        <identifiers>
          <isin value="US35104E1001"/>
        </identifiers>
        <balance>1249630.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>21481139.70000000</valUSD>
        <pctVal>0.331708841381</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="7052210.25000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Mirum Pharmaceuticals Inc</name>
        <lei>254900YZKR40F7F27K81</lei>
        <title>Mirum Pharmaceuticals Inc</title>
        <cusip>604749101</cusip>
        <identifiers>
          <isin value="US6047491013"/>
        </identifiers>
        <balance>798418.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19178000.36000000</valUSD>
        <pctVal>0.296144076537</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="409454.82000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Roivant Sciences Ltd</name>
        <lei>549300DL466NY5J6U724</lei>
        <title>Roivant Sciences Ltd</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="BMG762791017"/>
        </identifiers>
        <balance>6916388.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>51042943.44000000</valUSD>
        <pctVal>0.788198199241</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BM</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Xencor Inc</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>Xencor Inc</title>
        <cusip>98401F105</cusip>
        <identifiers>
          <isin value="US98401F1057"/>
        </identifiers>
        <balance>1177952.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>32853081.28000000</valUSD>
        <pctVal>0.507312818565</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Allogene Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Allogene Therapeutics Inc</title>
        <cusip>019770106</cusip>
        <identifiers>
          <isin value="US0197701065"/>
        </identifiers>
        <balance>6278024.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>31013438.56000000</valUSD>
        <pctVal>0.478905305569</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="26846874.06000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>State Street Global Advisors</name>
        <lei>5493000HFJPORCLSV250</lei>
        <title>State Street Institutional Liquid Reserves Fund</title>
        <cusip>85749P101</cusip>
        <identifiers>
          <isin value="US85749P1012"/>
        </identifiers>
        <balance>4303777.75000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4304208.13000000</valUSD>
        <pctVal>0.066464997286</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Agenus Inc</name>
        <lei>529900NDQQGU5H4UJK81</lei>
        <title>Agenus Inc</title>
        <cusip>00847G705</cusip>
        <identifiers>
          <isin value="US00847G7051"/>
        </identifiers>
        <balance>20228779.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>30747744.08000000</valUSD>
        <pctVal>0.474802487499</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="33136.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Gilead Sciences Inc</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>Gilead Sciences Inc</title>
        <cusip>375558103</cusip>
        <identifiers>
          <isin value="US3755581036"/>
        </identifiers>
        <balance>793433.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>65831136.01000000</valUSD>
        <pctVal>1.016555460170</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MannKind Corp</name>
        <lei>213800GFBCNY1ZFST722</lei>
        <title>MannKind Corp</title>
        <cusip>56400P706</cusip>
        <identifiers>
          <isin value="US56400P7069"/>
        </identifiers>
        <balance>12822164.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>52570872.40000000</valUSD>
        <pctVal>0.811792270697</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4583914.80000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zentalis Pharmaceuticals Inc</name>
        <lei>N/A</lei>
        <title>Zentalis Pharmaceuticals Inc</title>
        <cusip>98943L107</cusip>
        <identifiers>
          <isin value="US98943L1070"/>
        </identifiers>
        <balance>1937323.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>33321955.60000000</valUSD>
        <pctVal>0.514553112125</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="10634983.60000000"/>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>



    </explntrNotes>
    <signature>
      <ncom:dateSigned>2023-04-28</ncom:dateSigned>
      <ncom:nameOfApplicant>SPDR SERIES TRUST</ncom:nameOfApplicant>
      <ncom:signature>Arthur Jensen</ncom:signature>
      <ncom:signerName>Arthur Jensen</ncom:signerName>
      <ncom:title>Deputy Treasurer</ncom:title>
    </signature>
  </formData>
  <documents>XXXX</documents>
</edgarSubmission>
