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      <invstOrSec>
        <name>Verve Therapeutics Inc</name>
        <lei>N/A</lei>
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      <invstOrSec>
        <name>Keros Therapeutics Inc</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Anika Therapeutics Inc</name>
        <lei>529900R9LS3Z0O6QH455</lei>
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      <invstOrSec>
        <name>G1 Therapeutics Inc</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Adicet Bio Inc</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Catalyst Pharmaceuticals Inc</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>AbbVie Inc</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Ocugen Inc</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Prometheus Biosciences Inc</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Myriad Genetics Inc</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ChemoCentryx Inc</name>
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      <invstOrSec>
        <name>Lyell Immunopharma Inc</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>PMV Pharmaceuticals Inc</name>
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        <name>Avid Bioservices Inc</name>
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        <name>Chinook Therapeutics Inc</name>
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        <name>BioMarin Pharmaceutical Inc</name>
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        <name>Geron Corp</name>
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        <name>Eagle Pharmaceuticals Inc/DE</name>
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        <name>Viridian Therapeutics Inc</name>
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        <name>Sage Therapeutics Inc</name>
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        <name>Beam Therapeutics Inc</name>
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        <name>Seres Therapeutics Inc</name>
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        <name>Travere Therapeutics Inc</name>
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        <name>Erasca Inc</name>
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      <invstOrSec>
        <name>Vanda Pharmaceuticals Inc</name>
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      <invstOrSec>
        <name>Y-mAbs Therapeutics Inc</name>
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        <name>AnaptysBio Inc</name>
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        <name>Horizon Therapeutics Plc</name>
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        <name>Seagen Inc</name>
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      <invstOrSec>
        <name>Alector Inc</name>
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        <name>Agios Pharmaceuticals Inc</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Arcturus Therapeutics Holdings Inc</name>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Intellia Therapeutics Inc</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Point Biopharma Global Inc</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Halozyme Therapeutics Inc</name>
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      <invstOrSec>
        <name>Bluebird Bio Inc</name>
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      <invstOrSec>
        <name>Apellis Pharmaceuticals Inc</name>
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        <name>Biogen Inc</name>
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        <name>Madrigal Pharmaceuticals Inc</name>
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        <name>Ironwood Pharmaceuticals Inc</name>
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        <name>United Therapeutics Corp</name>
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        <name>ACADIA Pharmaceuticals Inc</name>
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        <name>CTI BioPharma Corp</name>
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        <name>REVOLUTION Medicines Inc</name>
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        <name>Moderna Inc</name>
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        <name>Iovance Biotherapeutics Inc</name>
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        <name>Mersana Therapeutics Inc</name>
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        <name>Recursion Pharmaceuticals Inc</name>
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        <name>ImmunoGen Inc</name>
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        <name>Twist Bioscience Corp</name>
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        <name>CRISPR Therapeutics AG</name>
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        <name>Denali Therapeutics Inc</name>
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        <name>Mirati Therapeutics Inc</name>
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        <name>Nkarta Inc</name>
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        <name>Sana Biotechnology Inc</name>
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        <name>Myovant Sciences Ltd</name>
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        <name>Cerevel Therapeutics Holdings Inc</name>
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        <name>Inovio Pharmaceuticals Inc</name>
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        <name>ImmunityBio Inc</name>
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        <name>Vaxart Inc</name>
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        <name>Alaunos Therapeutics Inc</name>
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        <name>Incyte Corp</name>
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        <name>Krystal Biotech Inc</name>
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        <name>State Street Global Advisors</name>
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        <name>Amgen Inc</name>
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        <name>Ideaya Biosciences Inc</name>
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        <name>Karuna Therapeutics Inc</name>
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        <name>Avidity Biosciences Inc</name>
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        <title>Avidity Biosciences Inc</title>
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      <invstOrSec>
        <name>Insmed Inc</name>
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      <invstOrSec>
        <name>RAPT Therapeutics Inc</name>
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      <invstOrSec>
        <name>Arcus Biosciences Inc</name>
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      <invstOrSec>
        <name>Arcutis Biotherapeutics Inc</name>
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      <invstOrSec>
        <name>Vir Biotechnology Inc</name>
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      <invstOrSec>
        <name>Design Therapeutics Inc</name>
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      <invstOrSec>
        <name>Vericel Corp</name>
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        <name>Altimmune Inc</name>
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      <invstOrSec>
        <name>Cogent Biosciences Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Emergent BioSolutions Inc</name>
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        <name>Natera Inc</name>
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        <name>Neurocrine Biosciences Inc</name>
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        <name>Exelixis Inc</name>
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        <name>Editas Medicine Inc</name>
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        <name>Crinetics Pharmaceuticals Inc</name>
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        <name>Cytokinetics Inc</name>
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        <name>Inhibrx Inc</name>
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        <name>Nurix Therapeutics Inc</name>
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        <name>Syndax Pharmaceuticals Inc</name>
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        <name>REGENXBIO Inc</name>
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        <name>Biohaven Pharmaceutical Holding Co Ltd</name>
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        <name>Day One Biopharmaceuticals Inc</name>
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          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Rocket Pharmaceuticals Inc</name>
        <lei>549300R7VV82YUIN4Y93</lei>
        <title>Rocket Pharmaceuticals Inc</title>
        <cusip>77313F106</cusip>
        <identifiers>
          <isin value="US77313F1066"/>
        </identifiers>
        <balance>2474884.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>39499148.64000000</valUSD>
        <pctVal>0.573717486964</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Atara Biotherapeutics Inc</name>
        <lei>549300WBXUXZRE03MS38</lei>
        <title>Atara Biotherapeutics Inc</title>
        <cusip>046513107</cusip>
        <identifiers>
          <isin value="US0465131078"/>
        </identifiers>
        <balance>5826106.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>22022680.68000000</valUSD>
        <pctVal>0.319875173288</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1127233.80000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EQRx Inc</name>
        <lei>N/A</lei>
        <title>EQRx Inc</title>
        <cusip>26886C107</cusip>
        <identifiers>
          <isin value="US26886C1071"/>
        </identifiers>
        <balance>6390971.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>31635306.45000000</valUSD>
        <pctVal>0.459496701593</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3825003.60000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Coherus Biosciences Inc</name>
        <lei>5493007IL8W5MV932D26</lei>
        <title>Coherus Biosciences Inc</title>
        <cusip>19249H103</cusip>
        <identifiers>
          <isin value="US19249H1032"/>
        </identifiers>
        <balance>2934850.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>28203908.50000000</valUSD>
        <pctVal>0.409656310688</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alkermes PLC</name>
        <lei>N/A</lei>
        <title>Alkermes PLC</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="IE00B56GVS15"/>
        </identifiers>
        <balance>3162987.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>70629499.71000000</valUSD>
        <pctVal>1.025879809423</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Amicus Therapeutics Inc</name>
        <lei>549300MRD1SMUTNBPQ53</lei>
        <title>Amicus Therapeutics Inc</title>
        <cusip>03152W109</cusip>
        <identifiers>
          <isin value="US03152W1099"/>
        </identifiers>
        <balance>6650053.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>69426553.32000000</valUSD>
        <pctVal>1.008407245998</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>C4 Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>C4 Therapeutics Inc</title>
        <cusip>12529R107</cusip>
        <identifiers>
          <isin value="US12529R1077"/>
        </identifiers>
        <balance>1229883.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10786073.91000000</valUSD>
        <pctVal>0.156665635359</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PTC Therapeutics Inc</name>
        <lei>549300UJLWOIWFDGB318</lei>
        <title>PTC Therapeutics Inc</title>
        <cusip>69366J200</cusip>
        <identifiers>
          <isin value="US69366J2006"/>
        </identifiers>
        <balance>1415746.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>71070449.20000000</valUSD>
        <pctVal>1.032284515397</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Novavax Inc</name>
        <lei>529900J4GJHPEPQ23205</lei>
        <title>Novavax Inc</title>
        <cusip>670002401</cusip>
        <identifiers>
          <isin value="US6700024010"/>
        </identifiers>
        <balance>2394072.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43572110.40000000</valUSD>
        <pctVal>0.632876468003</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="39105233.73000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Karyopharm Therapeutics Inc</name>
        <lei>549300J1VANRCNTYST87</lei>
        <title>Karyopharm Therapeutics Inc</title>
        <cusip>48576U106</cusip>
        <identifiers>
          <isin value="US48576U1060"/>
        </identifiers>
        <balance>7295945.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>39835859.70000000</valUSD>
        <pctVal>0.578608149923</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5717439.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SpringWorks Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>SpringWorks Therapeutics Inc</title>
        <cusip>85205L107</cusip>
        <identifiers>
          <isin value="US85205L1070"/>
        </identifiers>
        <balance>2678542.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>76418803.26000000</valUSD>
        <pctVal>1.109968322678</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="30435090.75000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>uniQure NV</name>
        <lei>724500RPCTZLFYJZ3S98</lei>
        <title>uniQure NV</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="NL0010696654"/>
        </identifiers>
        <balance>2298826.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43125975.76000000</valUSD>
        <pctVal>0.626396448729</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Mirum Pharmaceuticals Inc</name>
        <lei>254900YZKR40F7F27K81</lei>
        <title>Mirum Pharmaceuticals Inc</title>
        <cusip>604749101</cusip>
        <identifiers>
          <isin value="US6047491013"/>
        </identifiers>
        <balance>638127.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13407048.27000000</valUSD>
        <pctVal>0.194734780518</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Xencor Inc</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>Xencor Inc</title>
        <cusip>98401F105</cusip>
        <identifiers>
          <isin value="US98401F1057"/>
        </identifiers>
        <balance>1247898.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>32420390.04000000</valUSD>
        <pctVal>0.470899888746</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Allogene Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Allogene Therapeutics Inc</title>
        <cusip>019770106</cusip>
        <identifiers>
          <isin value="US0197701065"/>
        </identifiers>
        <balance>5039509.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>54426697.20000000</valUSD>
        <pctVal>0.790537239826</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="48787260.96000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>State Street Global Advisors</name>
        <lei>5493000HFJPORCLSV250</lei>
        <title>State Street Institutional Liquid Reserves Fund</title>
        <cusip>85749P101</cusip>
        <identifiers>
          <isin value="US85749P1012"/>
        </identifiers>
        <balance>7216174.01000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7217617.24000000</valUSD>
        <pctVal>0.104834493080</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Agenus Inc</name>
        <lei>529900NDQQGU5H4UJK81</lei>
        <title>Agenus Inc</title>
        <cusip>00847G705</cusip>
        <identifiers>
          <isin value="US00847G7051"/>
        </identifiers>
        <balance>15230776.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>31223090.80000000</valUSD>
        <pctVal>0.453509349082</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="6941165.88000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Gilead Sciences Inc</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>Gilead Sciences Inc</title>
        <cusip>375558103</cusip>
        <identifiers>
          <isin value="US3755581036"/>
        </identifiers>
        <balance>1163348.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>71766938.12000000</valUSD>
        <pctVal>1.042400882120</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MannKind Corp</name>
        <lei>213800GFBCNY1ZFST722</lei>
        <title>MannKind Corp</title>
        <cusip>56400P706</cusip>
        <identifiers>
          <isin value="US56400P7069"/>
        </identifiers>
        <balance>15956671.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>49306113.39000000</valUSD>
        <pctVal>0.716161751330</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="19233987.67000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zentalis Pharmaceuticals Inc</name>
        <lei>N/A</lei>
        <title>Zentalis Pharmaceuticals Inc</title>
        <cusip>98943L107</cusip>
        <identifiers>
          <isin value="US98943L1070"/>
        </identifiers>
        <balance>2006062.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43451302.92000000</valUSD>
        <pctVal>0.631121762744</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>



    </explntrNotes>
    <signature>
      <ncom:dateSigned>2022-10-28</ncom:dateSigned>
      <ncom:nameOfApplicant>SPDR SERIES TRUST</ncom:nameOfApplicant>
      <ncom:signature>Arthur Jensen</ncom:signature>
      <ncom:signerName>Arthur Jensen</ncom:signerName>
      <ncom:title>Deputy Treasurer</ncom:title>
    </signature>
  </formData>
  <documents>XXXX</documents>
</edgarSubmission>
