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        <name>AbbVie Inc</name>
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      <invstOrSec>
        <name>Ocugen Inc</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Myriad Genetics Inc</name>
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        <name>ChemoCentryx Inc</name>
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        <name>PMV Pharmaceuticals Inc</name>
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        <name>Avid Bioservices Inc</name>
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        <name>Chinook Therapeutics Inc</name>
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        <name>BioMarin Pharmaceutical Inc</name>
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        <name>Geron Corp</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Eagle Pharmaceuticals Inc/DE</name>
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        <name>Sage Therapeutics Inc</name>
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        <name>Beam Therapeutics Inc</name>
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        <name>Travere Therapeutics Inc</name>
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        <name>Vanda Pharmaceuticals Inc</name>
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        <name>Y-mAbs Therapeutics Inc</name>
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        <name>Praxis Precision Medicines Inc</name>
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        <name>AnaptysBio Inc</name>
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        <name>Seagen Inc</name>
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        <name>Alector Inc</name>
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        <name>Point Biopharma Global Inc</name>
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        <name>CTI BioPharma Corp</name>
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        <name>REVOLUTION Medicines Inc</name>
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        <name>ImmunoGen Inc</name>
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      <invstOrSec>
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        <name>Vaxart Inc</name>
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        <name>State Street Global Advisors</name>
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        <name>Amgen Inc</name>
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        <name>Karuna Therapeutics Inc</name>
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        <name>Avidity Biosciences Inc</name>
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        <name>Replimune Group Inc</name>
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        <name>Veracyte Inc</name>
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        <name>Vaxcyte Inc</name>
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        <name>Aadi Bioscience Inc</name>
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        <name>Sorrento Therapeutics Inc</name>
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        <name>Blueprint Medicines Corp</name>
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        <name>Morphic Holding Inc</name>
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        <name>Biohaven Pharmaceutical Holding Co Ltd</name>
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        <name>Rocket Pharmaceuticals Inc</name>
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        <name>Atara Biotherapeutics Inc</name>
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        <name>EQRx Inc</name>
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        <name>Coherus Biosciences Inc</name>
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        <name>Alkermes PLC</name>
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        <name>MannKind Corp</name>
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        <curCd>USD</curCd>
        <valUSD>29022122.55000000</valUSD>
        <pctVal>0.421055355087</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="16975170.48000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zentalis Pharmaceuticals Inc</name>
        <lei>N/A</lei>
        <title>Zentalis Pharmaceuticals Inc</title>
        <cusip>98943L107</cusip>
        <identifiers>
          <isin value="US98943L1070"/>
        </identifiers>
        <balance>2365071.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>66458495.10000000</valUSD>
        <pctVal>0.964185345323</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>



    </explntrNotes>
    <signature>
      <ncom:dateSigned>2022-07-27</ncom:dateSigned>
      <ncom:nameOfApplicant>SPDR SERIES TRUST</ncom:nameOfApplicant>
      <ncom:signature>Arthur Jensen</ncom:signature>
      <ncom:signerName>Arthur Jensen</ncom:signerName>
      <ncom:title>Deputy Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
