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      <invstOrSec>
        <name>Vertex Pharmaceuticals Inc</name>
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      <invstOrSec>
        <name>BioCryst Pharmaceuticals Inc</name>
        <lei>549300Z0INP1Z5NP6J59</lei>
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      <invstOrSec>
        <name>Exact Sciences Corp</name>
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      <invstOrSec>
        <name>Intercept Pharmaceuticals Inc</name>
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      <invstOrSec>
        <name>Keros Therapeutics Inc</name>
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      <invstOrSec>
        <name>Anika Therapeutics Inc</name>
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        <name>Rubius Therapeutics Inc</name>
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        <name>Dicerna Pharmaceuticals Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>G1 Therapeutics Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Catalyst Pharmaceuticals Inc</name>
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      <invstOrSec>
        <name>AbbVie Inc</name>
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        <name>Ocugen Inc</name>
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        <name>Myriad Genetics Inc</name>
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        <name>ChemoCentryx Inc</name>
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        <name>Humanigen Inc</name>
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        <name>PMV Pharmaceuticals Inc</name>
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        <name>Allovir Inc</name>
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        <name>Avid Bioservices Inc</name>
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        <name>Chinook Therapeutics Inc</name>
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        <name>BioMarin Pharmaceutical Inc</name>
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        <name>Geron Corp</name>
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        <name>Eagle Pharmaceuticals Inc/DE</name>
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        <name>Spectrum Pharmaceuticals Inc</name>
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      <invstOrSec>
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        <name>ImmunityBio Inc</name>
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        <name>Vaxart Inc</name>
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        <name>Precision BioSciences Inc</name>
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        <name>Incyte Corp</name>
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        <name>Krystal Biotech Inc</name>
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        <name>State Street Global Advisors</name>
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        <name>Amgen Inc</name>
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        <name>Ideaya Biosciences Inc</name>
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        <name>Avidity Biosciences Inc</name>
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        <name>IGM Biosciences Inc</name>
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        <name>Kodiak Sciences Inc</name>
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        <name>Selecta Biosciences Inc</name>
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        <name>Immunovant Inc</name>
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        <name>Biohaven Pharmaceutical Holding Co Ltd</name>
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        <name>Arena Pharmaceuticals Inc</name>
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        <name>Rocket Pharmaceuticals Inc</name>
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        <name>Atara Biotherapeutics Inc</name>
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        <name>Alkermes PLC</name>
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        <pctVal>0.360559107253</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2481304.85000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Allogene Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Allogene Therapeutics Inc</title>
        <cusip>019770106</cusip>
        <identifiers>
          <isin value="US0197701065"/>
        </identifiers>
        <balance>2215764.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>56945134.80000000</valUSD>
        <pctVal>0.788743344450</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1996093.30000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>State Street Global Advisors</name>
        <lei>5493000HFJPORCLSV250</lei>
        <title>State Street Institutional Liquid Reserves Fund</title>
        <cusip>85749P101</cusip>
        <identifiers>
          <isin value="US85749P1012"/>
        </identifiers>
        <balance>3577019.35000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3577734.75000000</valUSD>
        <pctVal>0.049554970449</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Agenus Inc</name>
        <lei>529900NDQQGU5H4UJK81</lei>
        <title>Agenus Inc</title>
        <cusip>00847G705</cusip>
        <identifiers>
          <isin value="US00847G7051"/>
        </identifiers>
        <balance>8432844.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>44272431.00000000</valUSD>
        <pctVal>0.613214551454</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="397425.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Gilead Sciences Inc</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>Gilead Sciences Inc</title>
        <cusip>375558103</cusip>
        <identifiers>
          <isin value="US3755581036"/>
        </identifiers>
        <balance>772085.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>53930137.25000000</valUSD>
        <pctVal>0.746982810219</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MannKind Corp</name>
        <lei>213800GFBCNY1ZFST722</lei>
        <title>MannKind Corp</title>
        <cusip>56400P706</cusip>
        <identifiers>
          <isin value="US56400P7069"/>
        </identifiers>
        <balance>8828751.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>38405066.85000000</valUSD>
        <pctVal>0.531946073663</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="30341193.52000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zentalis Pharmaceuticals Inc</name>
        <lei>N/A</lei>
        <title>Zentalis Pharmaceuticals Inc</title>
        <cusip>98943L107</cusip>
        <identifiers>
          <isin value="US98943L1070"/>
        </identifiers>
        <balance>661022.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>44050506.08000000</valUSD>
        <pctVal>0.610140683876</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4044514.88000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CEL-SCI Corp</name>
        <lei>549300FIWOFSETIVMI17</lei>
        <title>CEL-SCI Corp</title>
        <cusip>150837607</cusip>
        <identifiers>
          <isin value="US1508376076"/>
        </identifiers>
        <balance>3746827.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>41177628.73000000</valUSD>
        <pctVal>0.570348647257</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="33912839.33000000"/>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>



    </explntrNotes>
    <signature>
      <ncom:dateSigned>2021-10-29</ncom:dateSigned>
      <ncom:nameOfApplicant>SPDR SERIES TRUST</ncom:nameOfApplicant>
      <ncom:signature>Arthur Jensen</ncom:signature>
      <ncom:signerName>Arthur Jensen</ncom:signerName>
      <ncom:title>Deputy Treasurer</ncom:title>
    </signature>
  </formData>
  <documents>XXXX</documents>
</edgarSubmission>
