<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/nport" xmlns:com="http://www.sec.gov/edgar/common" xmlns:ncom="http://www.sec.gov/edgar/nportcommon" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.sec.gov/edgar/nport eis_NPORT_Filer.xsd">
  <headerData>
    <submissionType>NPORT-P</submissionType>
    <isConfidential>false</isConfidential>
    <filerInfo>

      <filer>
        <issuerCredentials>
          <cik>0001064642</cik>
          <ccc>XXXXXXXX</ccc>
        </issuerCredentials>
      </filer>


      <seriesClassInfo>
        <seriesId>S000010018</seriesId>
        <classId>C000027706</classId>
      </seriesClassInfo>


    </filerInfo>
  </headerData>
  <formData>
    <genInfo>
      <regName>SPDR SERIES TRUST</regName>
      <regFileNumber>811-08839</regFileNumber>
      <regCik>0001064642</regCik>
      <regLei>5493004JVD6CQEEJSS37</regLei>
      <regStreet1>One Iron Street</regStreet1>
      <regCity>Boston</regCity>
      <regStateConditional regCountry="US" regState="US-MA"/>
      <regZipOrPostalCode>02210</regZipOrPostalCode>
      <regPhone>617-664-8594</regPhone>
      <seriesName>SPDR(R) S&amp;P(R) Biotech ETF</seriesName>
      <seriesId>S000010018</seriesId>
      <seriesLei>549300Y3ODFMPD5XXL58</seriesLei>
      <repPdEnd>2021-06-30</repPdEnd>
      <repPdDate>2021-06-30</repPdDate>
      <isFinalFiling>N</isFinalFiling>
    </genInfo>
    <fundInfo>
      <totAssets>8640042387.60</totAssets>
      <totLiabs>1276925629.02</totLiabs>
      <netAssets>7363116758.58</netAssets>
      <assetsAttrMiscSec>0.00000000</assetsAttrMiscSec>
      <assetsInvested>0.00000000</assetsInvested>
      <amtPayOneYrBanksBorr>0.00000000</amtPayOneYrBanksBorr>
      <amtPayOneYrCtrldComp>0.00000000</amtPayOneYrCtrldComp>
      <amtPayOneYrOthAffil>0.00000000</amtPayOneYrOthAffil>
      <amtPayOneYrOther>0.00000000</amtPayOneYrOther>
      <amtPayAftOneYrBanksBorr>0.00000000</amtPayAftOneYrBanksBorr>
      <amtPayAftOneYrCtrldComp>0.00000000</amtPayAftOneYrCtrldComp>
      <amtPayAftOneYrOthAffil>0.00000000</amtPayAftOneYrOthAffil>
      <amtPayAftOneYrOther>0.00000000</amtPayAftOneYrOther>
      <delayDeliv>0.00000000</delayDeliv>
      <standByCommit>0.00000000</standByCommit>
      <liquidPref>0.00000000</liquidPref>
      <cshNotRptdInCorD>0.00000000</cshNotRptdInCorD>
      <borrowers>
        <borrower aggrVal="237615229.07000000" lei="G5GSEF7VJP5I7OUK5573" name="Barclays Bank PLC"/>
        <borrower aggrVal="20274419.40000000" lei="RCNB6OTYUAMMP879YW96" name="BNP Paribas Securities Corp."/>
        <borrower aggrVal="743980.00000000" lei="K5HU16E3LMSVCCJJJ255" name="MUFG Securities Americas Inc."/>
        <borrower aggrVal="6702064.61000000" lei="RUC0QBLBRPRCU4W1NE59" name="BMO Capital Markets Corp."/>
        <borrower aggrVal="80950497.77000000" lei="58PU97L1C0WSRCWADL48" name="Jefferies LLC"/>
        <borrower aggrVal="33637888.65000000" lei="549300BLWPABP1VNME36" name="Scotia Capital (USA) Inc."/>
        <borrower aggrVal="431503955.86000000" lei="ZBUT11V806EZRVTWT807" name="J.P. Morgan Securities LLC"/>
        <borrower aggrVal="65333432.19000000" lei="BFM8T61CT2L1QCEMIK50" name="UBS AG"/>
        <borrower aggrVal="166585940.99000000" lei="1V8Y6QCX6YMJ2OELII46" name="Credit Suisse Securities (USA) LLC"/>
        <borrower aggrVal="1099966.92000000" lei="KB1H1DSPRFMYMCUFXT09" name="Wells Fargo Bank, National Association"/>
        <borrower aggrVal="60556963.15000000" lei="MBNUM2BPBDO7JBLYG310" name="Citigroup Global Markets Inc."/>
        <borrower aggrVal="106146450.64000000" lei="549300HN4UKV1E2R3U73" name="BofA Securities, Inc."/>
        <borrower aggrVal="94531991.15000000" lei="FOR8UP27PHTHYVLBNG30" name="Goldman Sachs &amp; Co. LLC"/>
        <borrower aggrVal="7612958.49000000" lei="OXTKY6Q8X53C9ILVV871" name="Nomura Securities International, Inc."/>
        <borrower aggrVal="36006462.58000000" lei="549300JRHF1MHHWUAW04" name="National Financial Services LLC"/>
        <borrower aggrVal="11477677.37000000" lei="549300L8G1E7ZHVEOG75" name="Natixis Securities Americas LLC"/>
        <borrower aggrVal="160944616.64000000" lei="AC28XWWI3WIBK2824319" name="Barclays Capital Inc."/>
        <borrower aggrVal="20933249.39000000" lei="549300F35UE0BOM1WJ55" name="SG Americas Securities, LLC"/>
        <borrower aggrVal="205692.48000000" lei="4ZHCHI4KYZG2WVRT8631" name="Macquarie Bank Limited"/>
        <borrower aggrVal="13273338.29000000" lei="T6FIZBDPKLYJKFCRVK44" name="UBS Securities LLC"/>
        <borrower aggrVal="19395369.15000000" lei="549300LCO2FLSSVFFR64" name="RBC Capital Markets, LLC"/>
        <borrower aggrVal="78604452.30000000" lei="9R7GPTSO7KV3UQJZQ078" name="Morgan Stanley &amp; Co. LLC"/>
        <borrower aggrVal="8693464.21000000" lei="9J6MBOOO7BECTDTUZW19" name="Deutsche Bank Securities Inc."/>
        <borrower aggrVal="7128138.76000000" lei="VYVVCKR63DVZZN70PB21" name="Wells Fargo Securities, LLC"/>
      </borrowers>
      <aggregateCondition isNonCashCollateral="Y">
        <aggregateInfos>
          <aggregateInfo amt="842076637.81000000" collatrl="904102010.71000000">
            <invstCat>UST</invstCat>
          </aggregateInfo>
        </aggregateInfos>
      </aggregateCondition>
      <returnInfo>
        <monthlyTotReturns>
          <monthlyTotReturn classId="C000027706" rtn1="0.76000000" rtn2="-6.44000000" rtn3="5.97000000"/>
        </monthlyTotReturns>
        <monthlyReturnCats>
          <equityContracts>
            <mon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <otherCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </otherCategory>
          </equityContracts>
        </monthlyReturnCats>
        <othMon1 netRealizedGain="107790475.47000000" netUnrealizedAppr="-38976968.67000000"/>
        <othMon2 netRealizedGain="94109864.95000000" netUnrealizedAppr="-571433232.91000000"/>
        <othMon3 netRealizedGain="-124625139.36000000" netUnrealizedAppr="527524602.53000000"/>
      </returnInfo>
      <mon1Flow redemption="2058281104.41000000" reinvestment="0.00000000" sales="2256893920.38000000"/>
      <mon2Flow redemption="2196742980.59000000" reinvestment="0.00000000" sales="1898552850.01000000"/>
      <mon3Flow redemption="2694381839.68000000" reinvestment="0.00000000" sales="2892281789.46000000"/>


    </fundInfo>
    <invstOrSecs>
      <invstOrSec>
        <name>Ionis Pharmaceuticals Inc</name>
        <lei>549300SI4ZGLG0BLUZ92</lei>
        <title>Ionis Pharmaceuticals Inc</title>
        <cusip>462222100</cusip>
        <identifiers>
          <isin value="US4622221004"/>
        </identifiers>
        <balance>1211989.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>48346241.21000000</valUSD>
        <pctVal>0.656600225083</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="33331271.65000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MiMedx Group Inc</name>
        <lei>N/A</lei>
        <title>MiMedx Group Inc</title>
        <cusip>602496101</cusip>
        <identifiers>
          <isin value="US6024961012"/>
        </identifiers>
        <balance>1648728.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>20625587.28000000</valUSD>
        <pctVal>0.280120334313</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="15378205.28000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Generation Bio Co</name>
        <lei>N/A</lei>
        <title>Generation Bio Co</title>
        <cusip>37148K100</cusip>
        <identifiers>
          <isin value="US37148K1007"/>
        </identifiers>
        <balance>1540747.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>41446094.30000000</valUSD>
        <pctVal>0.562887913623</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="17602318.41000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>DermTech Inc</name>
        <lei>N/A</lei>
        <title>DermTech Inc</title>
        <cusip>24984K105</cusip>
        <identifiers>
          <isin value="US24984K1051"/>
        </identifiers>
        <balance>1133682.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>47127160.74000000</valUSD>
        <pctVal>0.640043643000</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5535964.91000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Avrobio Inc</name>
        <lei>N/A</lei>
        <title>Avrobio Inc</title>
        <cusip>05455M100</cusip>
        <identifiers>
          <isin value="US05455M1009"/>
        </identifiers>
        <balance>1919994.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17068746.66000000</valUSD>
        <pctVal>0.231814151800</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="572078.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ligand Pharmaceuticals Inc</name>
        <lei>5493008K7TB0IKP37H79</lei>
        <title>Ligand Pharmaceuticals Inc</title>
        <cusip>53220K504</cusip>
        <identifiers>
          <isin value="US53220K5048"/>
        </identifiers>
        <balance>371810.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>48777753.90000000</valUSD>
        <pctVal>0.662460687495</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="10566690.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Clovis Oncology Inc</name>
        <lei>529900WCUY9ZAHMRV489</lei>
        <title>Clovis Oncology Inc</title>
        <cusip>189464100</cusip>
        <identifiers>
          <isin value="US1894641000"/>
        </identifiers>
        <balance>7953408.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46129766.40000000</valUSD>
        <pctVal>0.626497825750</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="32794478.85000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Shattuck Labs Inc</name>
        <lei>N/A</lei>
        <title>Shattuck Labs Inc</title>
        <cusip>82024L103</cusip>
        <identifiers>
          <isin value="US82024L1035"/>
        </identifiers>
        <balance>502540.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14568634.60000000</valUSD>
        <pctVal>0.197859616758</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Arrowhead Pharmaceuticals Inc</name>
        <lei>549300O3CSB8T7OZ3D66</lei>
        <title>Arrowhead Pharmaceuticals Inc</title>
        <cusip>04280A100</cusip>
        <identifiers>
          <isin value="US04280A1007"/>
        </identifiers>
        <balance>518241.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>42920719.62000000</valUSD>
        <pctVal>0.582915102765</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Avita Medical Inc</name>
        <lei>N/A</lei>
        <title>Avita Medical Inc</title>
        <cusip>05380C102</cusip>
        <identifiers>
          <isin value="US05380C1027"/>
        </identifiers>
        <balance>480206.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9853827.12000000</valUSD>
        <pctVal>0.133826848644</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2939489.88000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Curis Inc</name>
        <lei>5299000YO6CX4WMFVX06</lei>
        <title>Curis Inc</title>
        <cusip>231269200</cusip>
        <identifiers>
          <isin value="US2312692005"/>
        </identifiers>
        <balance>5739117.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46314674.19000000</valUSD>
        <pctVal>0.629009096399</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="21708301.20000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KalVista Pharmaceuticals Inc</name>
        <lei>529900Q7IDA3WUGRZA51</lei>
        <title>KalVista Pharmaceuticals Inc</title>
        <cusip>483497103</cusip>
        <identifiers>
          <isin value="US4834971032"/>
        </identifiers>
        <balance>1052519.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>25218355.24000000</valUSD>
        <pctVal>0.342495658657</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="863184.19000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Protagonist Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Protagonist Therapeutics Inc</title>
        <cusip>74366E102</cusip>
        <identifiers>
          <isin value="US74366E1029"/>
        </identifiers>
        <balance>690706.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>30998885.28000000</valUSD>
        <pctVal>0.421002223601</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Rhythm Pharmaceuticals Inc</name>
        <lei>529900JPNWXQ8DPLA551</lei>
        <title>Rhythm Pharmaceuticals Inc</title>
        <cusip>76243J105</cusip>
        <identifiers>
          <isin value="US76243J1051"/>
        </identifiers>
        <balance>1463103.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>28647556.74000000</valUSD>
        <pctVal>0.389068348082</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1231099.36000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alnylam Pharmaceuticals Inc</name>
        <lei>529900S3ZI14OWRJII50</lei>
        <title>Alnylam Pharmaceuticals Inc</title>
        <cusip>02043Q107</cusip>
        <identifiers>
          <isin value="US02043Q1076"/>
        </identifiers>
        <balance>278512.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>47213354.24000000</valUSD>
        <pctVal>0.641214254615</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Anavex Life Sciences Corp</name>
        <lei>549300K1I5L8COCQ8W36</lei>
        <title>Anavex Life Sciences Corp</title>
        <cusip>032797300</cusip>
        <identifiers>
          <isin value="US0327973006"/>
        </identifiers>
        <balance>2965801.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>67798210.86000000</valUSD>
        <pctVal>0.920781417475</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="44061533.29000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Akebia Therapeutics Inc</name>
        <lei>549300CBQEHMKEEGNX42</lei>
        <title>Akebia Therapeutics Inc</title>
        <cusip>00972D105</cusip>
        <identifiers>
          <isin value="US00972D1054"/>
        </identifiers>
        <balance>10484877.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>39737683.83000000</valUSD>
        <pctVal>0.539685640373</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5330644.73000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Relay Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Relay Therapeutics Inc</title>
        <cusip>75943R102</cusip>
        <identifiers>
          <isin value="US75943R1023"/>
        </identifiers>
        <balance>1343376.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>49154127.84000000</valUSD>
        <pctVal>0.667572299226</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Kura Oncology Inc</name>
        <lei>5493005QORQTZCZYOP39</lei>
        <title>Kura Oncology Inc</title>
        <cusip>50127T109</cusip>
        <identifiers>
          <isin value="US50127T1097"/>
        </identifiers>
        <balance>2050374.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>42750297.90000000</valUSD>
        <pctVal>0.580600570406</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2426940.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vertex Pharmaceuticals Inc</name>
        <lei>54930015RAQRRZ5ZGJ91</lei>
        <title>Vertex Pharmaceuticals Inc</title>
        <cusip>92532F100</cusip>
        <identifiers>
          <isin value="US92532F1003"/>
        </identifiers>
        <balance>238140.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>48016168.20000000</valUSD>
        <pctVal>0.652117435786</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Translate Bio Inc</name>
        <lei>N/A</lei>
        <title>Translate Bio Inc</title>
        <cusip>89374L104</cusip>
        <identifiers>
          <isin value="US89374L1044"/>
        </identifiers>
        <balance>2149173.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>59188224.42000000</valUSD>
        <pctVal>0.803847424408</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="36309748.10000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BioCryst Pharmaceuticals Inc</name>
        <lei>549300Z0INP1Z5NP6J59</lei>
        <title>BioCryst Pharmaceuticals Inc</title>
        <cusip>09058V103</cusip>
        <identifiers>
          <isin value="US09058V1035"/>
        </identifiers>
        <balance>2751066.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43494353.46000000</valUSD>
        <pctVal>0.590705741686</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="25486936.20000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Exact Sciences Corp</name>
        <lei>549300VM3X1FYD4N9Z14</lei>
        <title>Exact Sciences Corp</title>
        <cusip>30063P105</cusip>
        <identifiers>
          <isin value="US30063P1057"/>
        </identifiers>
        <balance>377122.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46880035.82000000</valUSD>
        <pctVal>0.636687388738</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Intercept Pharmaceuticals Inc</name>
        <lei>N/A</lei>
        <title>Intercept Pharmaceuticals Inc</title>
        <cusip>45845P108</cusip>
        <identifiers>
          <isin value="US45845P1084"/>
        </identifiers>
        <balance>2132214.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>42580313.58000000</valUSD>
        <pctVal>0.578291978466</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="27260047.51000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Keros Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Keros Therapeutics Inc</title>
        <cusip>492327101</cusip>
        <identifiers>
          <isin value="US4923271013"/>
        </identifiers>
        <balance>446706.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18971603.82000000</valUSD>
        <pctVal>0.257657245457</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="454317.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Harpoon Therapeutics Inc</name>
        <lei>549300VFZL0TEVXILA36</lei>
        <title>Harpoon Therapeutics Inc</title>
        <cusip>41358P106</cusip>
        <identifiers>
          <isin value="US41358P1066"/>
        </identifiers>
        <balance>1049492.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14556454.04000000</valUSD>
        <pctVal>0.197694190072</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="56759.10000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Anika Therapeutics Inc</name>
        <lei>529900R9LS3Z0O6QH455</lei>
        <title>Anika Therapeutics Inc</title>
        <cusip>035255108</cusip>
        <identifiers>
          <isin value="US0352551081"/>
        </identifiers>
        <balance>349688.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>15137993.52000000</valUSD>
        <pctVal>0.205592197113</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="390408.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Rubius Therapeutics Inc</name>
        <lei>549300ER84PB0QV6HZ76</lei>
        <title>Rubius Therapeutics Inc</title>
        <cusip>78116T103</cusip>
        <identifiers>
          <isin value="US78116T1034"/>
        </identifiers>
        <balance>1665587.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>40656978.67000000</valUSD>
        <pctVal>0.552170772283</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1573458.48000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Dicerna Pharmaceuticals Inc</name>
        <lei>549300CTZMJMPH28WN39</lei>
        <title>Dicerna Pharmaceuticals Inc</title>
        <cusip>253031108</cusip>
        <identifiers>
          <isin value="US2530311081"/>
        </identifiers>
        <balance>1230440.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>45920020.80000000</valUSD>
        <pctVal>0.623649227706</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1029314.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>G1 Therapeutics Inc</name>
        <lei>529900TC35UPZQYRKW13</lei>
        <title>G1 Therapeutics Inc</title>
        <cusip>3621LQ109</cusip>
        <identifiers>
          <isin value="US3621LQ1099"/>
        </identifiers>
        <balance>2126293.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46650868.42000000</valUSD>
        <pctVal>0.633575019242</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="33620983.05000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Catalyst Pharmaceuticals Inc</name>
        <lei>5299004O0R5XXLA5H544</lei>
        <title>Catalyst Pharmaceuticals Inc</title>
        <cusip>14888U101</cusip>
        <identifiers>
          <isin value="US14888U1016"/>
        </identifiers>
        <balance>3386991.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19475198.25000000</valUSD>
        <pctVal>0.264496664775</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1591381.50000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AbbVie Inc</name>
        <lei>FR5LCKFTG8054YNNRU85</lei>
        <title>AbbVie Inc</title>
        <cusip>00287Y109</cusip>
        <identifiers>
          <isin value="US00287Y1091"/>
        </identifiers>
        <balance>398337.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>44868679.68000000</valUSD>
        <pctVal>0.609370748164</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ocugen Inc</name>
        <lei>549300JVNUI9CXWJLR09</lei>
        <title>Ocugen Inc</title>
        <cusip>67577C105</cusip>
        <identifiers>
          <isin value="US67577C1053"/>
        </identifiers>
        <balance>7250920.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>58224887.60000000</valUSD>
        <pctVal>0.790764149327</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="33666304.98000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Myriad Genetics Inc</name>
        <lei>52990044IHUOUMETT163</lei>
        <title>Myriad Genetics Inc</title>
        <cusip>62855J104</cusip>
        <identifiers>
          <isin value="US62855J1043"/>
        </identifiers>
        <balance>1546254.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>47284447.32000000</valUSD>
        <pctVal>0.642179784327</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ChemoCentryx Inc</name>
        <lei>529900YTTXUSFQTAKY40</lei>
        <title>ChemoCentryx Inc</title>
        <cusip>16383L106</cusip>
        <identifiers>
          <isin value="US16383L1061"/>
        </identifiers>
        <balance>3774264.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>50537394.96000000</valUSD>
        <pctVal>0.686358733903</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="470285.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Humanigen Inc</name>
        <lei>549300ILAUCQNMJQXL47</lei>
        <title>Humanigen Inc</title>
        <cusip>444863203</cusip>
        <identifiers>
          <isin value="US4448632038"/>
        </identifiers>
        <balance>2177640.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>37847383.20000000</valUSD>
        <pctVal>0.514013079527</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="9207924.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PMV Pharmaceuticals Inc</name>
        <lei>N/A</lei>
        <title>PMV Pharmaceuticals Inc</title>
        <cusip>69353Y103</cusip>
        <identifiers>
          <isin value="US69353Y1038"/>
        </identifiers>
        <balance>611729.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>20896662.64000000</valUSD>
        <pctVal>0.283801864416</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2318920.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Allovir Inc</name>
        <lei>N/A</lei>
        <title>Allovir Inc</title>
        <cusip>019818103</cusip>
        <identifiers>
          <isin value="US0198181036"/>
        </identifiers>
        <balance>1207887.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>23843689.38000000</valUSD>
        <pctVal>0.323826039458</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1466286.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Avid Bioservices Inc</name>
        <lei>549300GRUS3ZMGP8MX22</lei>
        <title>Avid Bioservices Inc</title>
        <cusip>05368M106</cusip>
        <identifiers>
          <isin value="US05368M1062"/>
        </identifiers>
        <balance>1438111.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>36887547.15000000</valUSD>
        <pctVal>0.500977349123</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="33345.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Chinook Therapeutics Inc</name>
        <lei>549300X0O3003W5QYQ48</lei>
        <title>Chinook Therapeutics Inc</title>
        <cusip>16961L106</cusip>
        <identifiers>
          <isin value="US16961L1061"/>
        </identifiers>
        <balance>448827.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6337437.24000000</valUSD>
        <pctVal>0.086070035934</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="274628.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BioMarin Pharmaceutical Inc</name>
        <lei>NSLL8ITTRR0J5HEMR848</lei>
        <title>BioMarin Pharmaceutical Inc</title>
        <cusip>09061G101</cusip>
        <identifiers>
          <isin value="US09061G1013"/>
        </identifiers>
        <balance>560176.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46741085.44000000</valUSD>
        <pctVal>0.634800275108</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1268566.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Geron Corp</name>
        <lei>549300T282D7Z2YESL90</lei>
        <title>Geron Corp</title>
        <cusip>374163103</cusip>
        <identifiers>
          <isin value="US3741631036"/>
        </identifiers>
        <balance>7844090.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11060166.90000000</valUSD>
        <pctVal>0.150210396801</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="9328642.66000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Eagle Pharmaceuticals Inc/DE</name>
        <lei>549300TN20OLYTJVP152</lei>
        <title>Eagle Pharmaceuticals Inc/DE</title>
        <cusip>269796108</cusip>
        <identifiers>
          <isin value="US2697961082"/>
        </identifiers>
        <balance>362231.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>15503486.80000000</valUSD>
        <pctVal>0.210556036367</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Spectrum Pharmaceuticals Inc</name>
        <lei>549300COU30WSP3O5I07</lei>
        <title>Spectrum Pharmaceuticals Inc</title>
        <cusip>84763A108</cusip>
        <identifiers>
          <isin value="US84763A1088"/>
        </identifiers>
        <balance>6384590.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>23942212.50000000</valUSD>
        <pctVal>0.325164102173</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="7146905.25000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sage Therapeutics Inc</name>
        <lei>5493000JX4BJS9W6CN35</lei>
        <title>Sage Therapeutics Inc</title>
        <cusip>78667J108</cusip>
        <identifiers>
          <isin value="US78667J1088"/>
        </identifiers>
        <balance>581123.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>33013597.63000000</valUSD>
        <pctVal>0.448364445552</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CytomX Therapeutics Inc</name>
        <lei>5493004VW2FW0QLL3345</lei>
        <title>CytomX Therapeutics Inc</title>
        <cusip>23284F105</cusip>
        <identifiers>
          <isin value="US23284F1057"/>
        </identifiers>
        <balance>3441563.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>21785093.79000000</valUSD>
        <pctVal>0.295867830217</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="158883.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Beam Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Beam Therapeutics Inc</title>
        <cusip>07373V105</cusip>
        <identifiers>
          <isin value="US07373V1052"/>
        </identifiers>
        <balance>517974.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>66668433.54000000</valUSD>
        <pctVal>0.905437679802</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="38783853.42000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Acceleron Pharma Inc</name>
        <lei>529900TQRID2UY164805</lei>
        <title>Acceleron Pharma Inc</title>
        <cusip>00434H108</cusip>
        <identifiers>
          <isin value="US00434H1086"/>
        </identifiers>
        <balance>344498.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43231054.02000000</valUSD>
        <pctVal>0.587129817948</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="501960.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Seres Therapeutics Inc</name>
        <lei>549300GMXBE5NUWISF13</lei>
        <title>Seres Therapeutics Inc</title>
        <cusip>81750R102</cusip>
        <identifiers>
          <isin value="US81750R1023"/>
        </identifiers>
        <balance>2238121.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>53379185.85000000</valUSD>
        <pctVal>0.724953679266</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="13736080.02000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Travere Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Travere Therapeutics Inc</title>
        <cusip>89422G107</cusip>
        <identifiers>
          <isin value="US89422G1076"/>
        </identifiers>
        <balance>2373184.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>34624754.56000000</valUSD>
        <pctVal>0.470245898513</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1084112.70000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vanda Pharmaceuticals Inc</name>
        <lei>529900AY8VOOQBKJ0O70</lei>
        <title>Vanda Pharmaceuticals Inc</title>
        <cusip>921659108</cusip>
        <identifiers>
          <isin value="US9216591084"/>
        </identifiers>
        <balance>1232758.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>26516624.58000000</valUSD>
        <pctVal>0.360127721037</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="30372.12000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Y-mAbs Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Y-mAbs Therapeutics Inc</title>
        <cusip>984241109</cusip>
        <identifiers>
          <isin value="US9842411095"/>
        </identifiers>
        <balance>805537.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>27227150.60000000</valUSD>
        <pctVal>0.369777520752</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AnaptysBio Inc</name>
        <lei>529900HH4WQT03IG1A12</lei>
        <title>AnaptysBio Inc</title>
        <cusip>032724106</cusip>
        <identifiers>
          <isin value="US0327241065"/>
        </identifiers>
        <balance>845284.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>21918214.12000000</valUSD>
        <pctVal>0.297675764742</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="70011.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Horizon Therapeutics Plc</name>
        <lei>529900P0GSQ79OOZEV53</lei>
        <title>Horizon Therapeutics Plc</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="IE00BQPVQZ61"/>
        </identifiers>
        <balance>492747.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46140829.08000000</valUSD>
        <pctVal>0.626648070278</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Seagen Inc</name>
        <lei>N/A</lei>
        <title>Seagen Inc</title>
        <cusip>81181C104</cusip>
        <identifiers>
          <isin value="US81181C1045"/>
        </identifiers>
        <balance>293551.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46345831.88000000</valUSD>
        <pctVal>0.629432255382</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Invitae Corp</name>
        <lei>549300MYI59DZW1WIX92</lei>
        <title>Invitae Corp</title>
        <cusip>46185L103</cusip>
        <identifiers>
          <isin value="US46185L1035"/>
        </identifiers>
        <balance>1472500.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>49667425.00000000</valUSD>
        <pctVal>0.674543493312</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="33748327.14000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alector Inc</name>
        <lei>549300Z8RQOIY1JMHC25</lei>
        <title>Alector Inc</title>
        <cusip>014442107</cusip>
        <identifiers>
          <isin value="US0144421072"/>
        </identifiers>
        <balance>1675190.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>34894207.70000000</valUSD>
        <pctVal>0.473905396914</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="29637901.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Agios Pharmaceuticals Inc</name>
        <lei>529900ONJHY8EOGYT555</lei>
        <title>Agios Pharmaceuticals Inc</title>
        <cusip>00847X104</cusip>
        <identifiers>
          <isin value="US00847X1046"/>
        </identifiers>
        <balance>796163.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43876542.93000000</valUSD>
        <pctVal>0.595896335323</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="36127116.53000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Esperion Therapeutics Inc</name>
        <lei>549300OFU56UKEWVUS92</lei>
        <title>Esperion Therapeutics Inc</title>
        <cusip>29664W105</cusip>
        <identifiers>
          <isin value="US29664W1053"/>
        </identifiers>
        <balance>1743239.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>36869504.85000000</valUSD>
        <pctVal>0.500732312943</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="25013562.05000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Precigen Inc</name>
        <lei>549300XCWNQU35K64G19</lei>
        <title>Precigen Inc</title>
        <cusip>74017N105</cusip>
        <identifiers>
          <isin value="US74017N1054"/>
        </identifiers>
        <balance>4085303.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>26636175.56000000</valUSD>
        <pctVal>0.361751367435</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="10841073.26000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Kadmon Holdings Inc</name>
        <lei>549300BBVICD23L50606</lei>
        <title>Kadmon Holdings Inc</title>
        <cusip>48283N106</cusip>
        <identifiers>
          <isin value="US48283N1063"/>
        </identifiers>
        <balance>7418802.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>28710763.74000000</valUSD>
        <pctVal>0.389926775323</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5838065.70000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Arcturus Therapeutics Holdings Inc</name>
        <lei>N/A</lei>
        <title>Arcturus Therapeutics Holdings Inc</title>
        <cusip>03969T109</cusip>
        <identifiers>
          <isin value="US03969T1097"/>
        </identifiers>
        <balance>1336716.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>45234469.44000000</valUSD>
        <pctVal>0.614338613974</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="33509505.60000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Intellia Therapeutics Inc</name>
        <lei>5493002T5BCPE5DZC723</lei>
        <title>Intellia Therapeutics Inc</title>
        <cusip>45826J105</cusip>
        <identifiers>
          <isin value="US45826J1051"/>
        </identifiers>
        <balance>538954.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>87262042.14000000</valUSD>
        <pctVal>1.185123705098</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4147972.29000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Turning Point Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Turning Point Therapeutics Inc</title>
        <cusip>90041T108</cusip>
        <identifiers>
          <isin value="US90041T1088"/>
        </identifiers>
        <balance>613520.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>47866830.40000000</valUSD>
        <pctVal>0.650089248472</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Halozyme Therapeutics Inc</name>
        <lei>529900242I3SV9AGM753</lei>
        <title>Halozyme Therapeutics Inc</title>
        <cusip>40637H109</cusip>
        <identifiers>
          <isin value="US40637H1095"/>
        </identifiers>
        <balance>1074379.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>48787550.39000000</valUSD>
        <pctVal>0.662593735637</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="744724.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Verastem Inc</name>
        <lei>549300IY0EFBIU8NQC81</lei>
        <title>Verastem Inc</title>
        <cusip>92337C104</cusip>
        <identifiers>
          <isin value="US92337C1045"/>
        </identifiers>
        <balance>4208547.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17128786.29000000</valUSD>
        <pctVal>0.232629562339</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="106372.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Bluebird Bio Inc</name>
        <lei>N/A</lei>
        <title>Bluebird Bio Inc</title>
        <cusip>09609G100</cusip>
        <identifiers>
          <isin value="US09609G1004"/>
        </identifiers>
        <balance>1348117.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43112781.66000000</valUSD>
        <pctVal>0.585523536751</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4397760.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Apellis Pharmaceuticals Inc</name>
        <lei>254900HS0ZFRXXSB9D42</lei>
        <title>Apellis Pharmaceuticals Inc</title>
        <cusip>03753U106</cusip>
        <identifiers>
          <isin value="US03753U1060"/>
        </identifiers>
        <balance>740024.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46769516.80000000</valUSD>
        <pctVal>0.635186407243</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="20878095.60000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Biogen Inc</name>
        <lei>W8J5WZB5IY3K0NDQT671</lei>
        <title>Biogen Inc</title>
        <cusip>09062X103</cusip>
        <identifiers>
          <isin value="US09062X1037"/>
        </identifiers>
        <balance>115918.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>40138925.86000000</valUSD>
        <pctVal>0.545134990739</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sesen Bio Inc</name>
        <lei>549300DGKHONOZQIY116</lei>
        <title>Sesen Bio Inc</title>
        <cusip>817763105</cusip>
        <identifiers>
          <isin value="US8177631053"/>
        </identifiers>
        <balance>10816560.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>49972507.20000000</valUSD>
        <pctVal>0.678686877289</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1347654.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Madrigal Pharmaceuticals Inc</name>
        <lei>549300CHIMT2EUSNJB60</lei>
        <title>Madrigal Pharmaceuticals Inc</title>
        <cusip>558868105</cusip>
        <identifiers>
          <isin value="US5588681057"/>
        </identifiers>
        <balance>425830.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>41480100.30000000</valUSD>
        <pctVal>0.563349756088</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Spero Therapeutics Inc</name>
        <lei>54930074G13LHWJT2323</lei>
        <title>Spero Therapeutics Inc</title>
        <cusip>84833T103</cusip>
        <identifiers>
          <isin value="US84833T1034"/>
        </identifiers>
        <balance>421087.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5878374.52000000</valUSD>
        <pctVal>0.079835410910</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4812403.21000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ironwood Pharmaceuticals Inc</name>
        <lei>549300PC8MR6QHH6P296</lei>
        <title>Ironwood Pharmaceuticals Inc</title>
        <cusip>46333X108</cusip>
        <identifiers>
          <isin value="US46333X1081"/>
        </identifiers>
        <balance>3919070.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>50438430.90000000</valUSD>
        <pctVal>0.685014682691</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="31125542.22000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>United Therapeutics Corp</name>
        <lei>5299005C4HZL4UWROC14</lei>
        <title>United Therapeutics Corp</title>
        <cusip>91307C102</cusip>
        <identifiers>
          <isin value="US91307C1027"/>
        </identifiers>
        <balance>256647.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46045038.27000000</valUSD>
        <pctVal>0.625347115626</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Albireo Pharma Inc</name>
        <lei>549300835H8LC7O8VC29</lei>
        <title>Albireo Pharma Inc</title>
        <cusip>01345P106</cusip>
        <identifiers>
          <isin value="US01345P1066"/>
        </identifiers>
        <balance>533221.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18758714.78000000</valUSD>
        <pctVal>0.254765955709</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="10247477.27000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ACADIA Pharmaceuticals Inc</name>
        <lei>529900O3044NO0PEA039</lei>
        <title>ACADIA Pharmaceuticals Inc</title>
        <cusip>004225108</cusip>
        <identifiers>
          <isin value="US0042251084"/>
        </identifiers>
        <balance>1676514.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>40890176.46000000</valUSD>
        <pctVal>0.555337879334</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Viking Therapeutics Inc</name>
        <lei>529900IVC72YPFA25M37</lei>
        <title>Viking Therapeutics Inc</title>
        <cusip>92686J106</cusip>
        <identifiers>
          <isin value="US92686J1060"/>
        </identifiers>
        <balance>3267990.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19575260.10000000</valUSD>
        <pctVal>0.265855625298</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="17004423.39000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>REVOLUTION Medicines Inc</name>
        <lei>549300JU3X0LBCQ65892</lei>
        <title>REVOLUTION Medicines Inc</title>
        <cusip>76155X100</cusip>
        <identifiers>
          <isin value="US76155X1000"/>
        </identifiers>
        <balance>1341465.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>42578099.10000000</valUSD>
        <pctVal>0.578261903159</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="17661732.46000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Moderna Inc</name>
        <lei>549300EI6OKH5K5Q2G38</lei>
        <title>Moderna Inc</title>
        <cusip>60770K107</cusip>
        <identifiers>
          <isin value="US60770K1079"/>
        </identifiers>
        <balance>210055.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>49358723.90000000</valUSD>
        <pctVal>0.670350960311</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Iovance Biotherapeutics Inc</name>
        <lei>549300220Z2GHH33XL82</lei>
        <title>Iovance Biotherapeutics Inc</title>
        <cusip>462260100</cusip>
        <identifiers>
          <isin value="US4622601007"/>
        </identifiers>
        <balance>1960391.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>51009373.82000000</valUSD>
        <pctVal>0.692768775675</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="35426141.04000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ORIC Pharmaceuticals Inc</name>
        <lei>54930033FJRNEYBW0L25</lei>
        <title>ORIC Pharmaceuticals Inc</title>
        <cusip>68622P109</cusip>
        <identifiers>
          <isin value="US68622P1093"/>
        </identifiers>
        <balance>839542.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14851497.98000000</valUSD>
        <pctVal>0.201701242380</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3474.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Passage Bio Inc</name>
        <lei>N/A</lei>
        <title>Passage Bio Inc</title>
        <cusip>702712100</cusip>
        <identifiers>
          <isin value="US7027121000"/>
        </identifiers>
        <balance>1245751.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16493743.24000000</valUSD>
        <pctVal>0.224004912332</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5899852.32000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Mersana Therapeutics Inc</name>
        <lei>529900VWD5VDZ7PVOS22</lei>
        <title>Mersana Therapeutics Inc</title>
        <cusip>59045L106</cusip>
        <identifiers>
          <isin value="US59045L1061"/>
        </identifiers>
        <balance>2070377.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>28115719.66000000</valUSD>
        <pctVal>0.381845359537</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="498644.02000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Celldex Therapeutics Inc</name>
        <lei>529900F018DMYWH38923</lei>
        <title>Celldex Therapeutics Inc</title>
        <cusip>15117B202</cusip>
        <identifiers>
          <isin value="US15117B2025"/>
        </identifiers>
        <balance>1383383.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46260327.52000000</valUSD>
        <pctVal>0.628271003119</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1535730.03000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ImmunoGen Inc</name>
        <lei>54930084U0R1OP766Y02</lei>
        <title>ImmunoGen Inc</title>
        <cusip>45253H101</cusip>
        <identifiers>
          <isin value="US45253H1014"/>
        </identifiers>
        <balance>7094216.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46750883.44000000</valUSD>
        <pctVal>0.634933343757</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Twist Bioscience Corp</name>
        <lei>549300T23BL59LCOH584</lei>
        <title>Twist Bioscience Corp</title>
        <cusip>90184D100</cusip>
        <identifiers>
          <isin value="US90184D1000"/>
        </identifiers>
        <balance>401085.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>53444576.25000000</valUSD>
        <pctVal>0.725841759710</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="26650.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Enanta Pharmaceuticals Inc</name>
        <lei>529900SSN4DODDQSN594</lei>
        <title>Enanta Pharmaceuticals Inc</title>
        <cusip>29251M106</cusip>
        <identifiers>
          <isin value="US29251M1062"/>
        </identifiers>
        <balance>432010.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19012760.10000000</valUSD>
        <pctVal>0.258216197343</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3009725.28000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Bioxcel Therapeutics Inc</name>
        <lei>549300Y25FYZ0E8LW260</lei>
        <title>Bioxcel Therapeutics Inc</title>
        <cusip>09075P105</cusip>
        <identifiers>
          <isin value="US09075P1057"/>
        </identifiers>
        <balance>1214185.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>35284216.10000000</valUSD>
        <pctVal>0.479202181044</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="13521536.58000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Denali Therapeutics Inc</name>
        <lei>549300ZTQ2HO18L3Q830</lei>
        <title>Denali Therapeutics Inc</title>
        <cusip>24823R105</cusip>
        <identifiers>
          <isin value="US24823R1059"/>
        </identifiers>
        <balance>612889.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>48075013.16000000</valUSD>
        <pctVal>0.652916621266</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Organogenesis Holdings Inc</name>
        <lei>549300RLC2O821TU6941</lei>
        <title>Organogenesis Holdings Inc</title>
        <cusip>68621F102</cusip>
        <identifiers>
          <isin value="US68621F1021"/>
        </identifiers>
        <balance>3040329.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>50530267.98000000</valUSD>
        <pctVal>0.686261940924</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="559179.90000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sutro Biopharma Inc</name>
        <lei>5493005U6P15VD25P851</lei>
        <title>Sutro Biopharma Inc</title>
        <cusip>869367102</cusip>
        <identifiers>
          <isin value="US8693671021"/>
        </identifiers>
        <balance>1553801.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>28885160.59000000</valUSD>
        <pctVal>0.392295294738</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2803759.16000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Kiniksa Pharmaceuticals Ltd</name>
        <lei>N/A</lei>
        <title>Kiniksa Pharmaceuticals Ltd</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="BMG5269C1010"/>
        </identifiers>
        <balance>1816646.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>25305878.78000000</valUSD>
        <pctVal>0.343684333818</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BM</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="12189972.14000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Mirati Therapeutics Inc</name>
        <lei>529900GYRW59IDQV6N54</lei>
        <title>Mirati Therapeutics Inc</title>
        <cusip>60468T105</cusip>
        <identifiers>
          <isin value="US60468T1051"/>
        </identifiers>
        <balance>267166.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43155323.98000000</valUSD>
        <pctVal>0.586101312731</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Nkarta Inc</name>
        <lei>N/A</lei>
        <title>Nkarta Inc</title>
        <cusip>65487U108</cusip>
        <identifiers>
          <isin value="US65487U1088"/>
        </identifiers>
        <balance>955237.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>30271460.53000000</valUSD>
        <pctVal>0.411122918765</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1144490.48000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sana Biotechnology Inc</name>
        <lei>N/A</lei>
        <title>Sana Biotechnology Inc</title>
        <cusip>799566104</cusip>
        <identifiers>
          <isin value="US7995661045"/>
        </identifiers>
        <balance>1538549.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>30247873.34000000</valUSD>
        <pctVal>0.410802576296</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="24611540.28000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Myovant Sciences Ltd</name>
        <lei>N/A</lei>
        <title>Myovant Sciences Ltd</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="BMG637AM1024"/>
        </identifiers>
        <balance>2034057.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46315477.89000000</valUSD>
        <pctVal>0.629020011614</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BM</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="10433227.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Akero Therapeutics Inc</name>
        <lei>549300SI3KG74LBE2955</lei>
        <title>Akero Therapeutics Inc</title>
        <cusip>00973Y108</cusip>
        <identifiers>
          <isin value="US00973Y1082"/>
        </identifiers>
        <balance>829047.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>20568656.07000000</valUSD>
        <pctVal>0.279347139864</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="14589133.65000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cerevel Therapeutics Holdings Inc</name>
        <lei>N/A</lei>
        <title>Cerevel Therapeutics Holdings Inc</title>
        <cusip>15678U128</cusip>
        <identifiers>
          <isin value="US15678U1280"/>
        </identifiers>
        <balance>737255.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18888473.10000000</valUSD>
        <pctVal>0.256528230086</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="16921026.38000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Inovio Pharmaceuticals Inc</name>
        <lei>529900B9W875XDZXTM97</lei>
        <title>Inovio Pharmaceuticals Inc</title>
        <cusip>45773H201</cusip>
        <identifiers>
          <isin value="US45773H2013"/>
        </identifiers>
        <balance>5051698.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46829240.46000000</valUSD>
        <pctVal>0.635997526528</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="24078787.92000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ImmunityBio Inc</name>
        <lei>529900J9XLBR4HFL4B83</lei>
        <title>ImmunityBio Inc</title>
        <cusip>45256X103</cusip>
        <identifiers>
          <isin value="US45256X1037"/>
        </identifiers>
        <balance>3026405.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43217063.40000000</valUSD>
        <pctVal>0.586939808466</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vaxart Inc</name>
        <lei>N/A</lei>
        <title>Vaxart Inc</title>
        <cusip>92243A200</cusip>
        <identifiers>
          <isin value="US92243A2006"/>
        </identifiers>
        <balance>5259769.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>39395669.81000000</valUSD>
        <pctVal>0.535040677768</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="31326524.56000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ZIOPHARM Oncology Inc</name>
        <lei>N/A</lei>
        <title>ZIOPHARM Oncology Inc</title>
        <cusip>98973P101</cusip>
        <identifiers>
          <isin value="US98973P1012"/>
        </identifiers>
        <balance>6631262.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17506531.68000000</valUSD>
        <pctVal>0.237759800014</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="14794210.80000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Precision BioSciences Inc</name>
        <lei>549300I5QGRS3BLHZH41</lei>
        <title>Precision BioSciences Inc</title>
        <cusip>74019P108</cusip>
        <identifiers>
          <isin value="US74019P1084"/>
        </identifiers>
        <balance>1799598.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>22530966.96000000</valUSD>
        <pctVal>0.305997686832</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="6128083.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Incyte Corp</name>
        <lei>549300Z4WN6JVZ3T4680</lei>
        <title>Incyte Corp</title>
        <cusip>45337C102</cusip>
        <identifiers>
          <isin value="US45337C1027"/>
        </identifiers>
        <balance>556672.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46832815.36000000</valUSD>
        <pctVal>0.636046077979</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Krystal Biotech Inc</name>
        <lei>549300YONUY68210OE41</lei>
        <title>Krystal Biotech Inc</title>
        <cusip>501147102</cusip>
        <identifiers>
          <isin value="US5011471027"/>
        </identifiers>
        <balance>394136.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>26801248.00000000</valUSD>
        <pctVal>0.363993250124</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="495074.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Fate Therapeutics Inc</name>
        <lei>549300L14Q4UHOODLA90</lei>
        <title>Fate Therapeutics Inc</title>
        <cusip>31189P102</cusip>
        <identifiers>
          <isin value="US31189P1021"/>
        </identifiers>
        <balance>512200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>44453838.00000000</valUSD>
        <pctVal>0.603736698161</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>State Street Global Advisors</name>
        <lei>5493008BJIBKQ5KTIF74</lei>
        <title>State Street Navigator Securities Lending Government Money Market Portfolio</title>
        <cusip>857492706</cusip>
        <identifiers>
          <isin value="US8574927062"/>
        </identifiers>
        <balance>827025039.50000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>827025039.50000000</valUSD>
        <pctVal>11.23199681081</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <cashCollateralCondition cashCollateralVal="827025039.50000000" isCashCollateral="Y"/>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TCR2 Therapeutics Inc</name>
        <lei>5493007TR1ORJAZ8YK34</lei>
        <title>TCR2 Therapeutics Inc</title>
        <cusip>87808K106</cusip>
        <identifiers>
          <isin value="US87808K1060"/>
        </identifiers>
        <balance>1703859.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>27960326.19000000</valUSD>
        <pctVal>0.379734928926</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Epizyme Inc</name>
        <lei>549300TNFWF88O4U4605</lei>
        <title>Epizyme Inc</title>
        <cusip>29428V104</cusip>
        <identifiers>
          <isin value="US29428V1044"/>
        </identifiers>
        <balance>3878891.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>32233584.21000000</valUSD>
        <pctVal>0.437770923195</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="6277324.42000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Amgen Inc</name>
        <lei>62QBXGPJ34PQ72Z12S66</lei>
        <title>Amgen Inc</title>
        <cusip>031162100</cusip>
        <identifiers>
          <isin value="US0311621009"/>
        </identifiers>
        <balance>189356.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46155525.00000000</valUSD>
        <pctVal>0.626847658584</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Adverum Biotechnologies Inc</name>
        <lei>529900ZEDOOZL1EWHJ89</lei>
        <title>Adverum Biotechnologies Inc</title>
        <cusip>00773U108</cusip>
        <identifiers>
          <isin value="US00773U1088"/>
        </identifiers>
        <balance>7891515.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>27620302.50000000</valUSD>
        <pctVal>0.375116997402</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3303441.44000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Karuna Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Karuna Therapeutics Inc</title>
        <cusip>48576A100</cusip>
        <identifiers>
          <isin value="US48576A1007"/>
        </identifiers>
        <balance>338153.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>38546060.47000000</valUSD>
        <pctVal>0.523501958937</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="11487699.53000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Avidity Biosciences Inc</name>
        <lei>N/A</lei>
        <title>Avidity Biosciences Inc</title>
        <cusip>05370A108</cusip>
        <identifiers>
          <isin value="US05370A1088"/>
        </identifiers>
        <balance>849397.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>20988599.87000000</valUSD>
        <pctVal>0.285050482807</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="14212067.66000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Allakos Inc</name>
        <lei>549300S6ZD1W6BPMDY37</lei>
        <title>Allakos Inc</title>
        <cusip>01671P100</cusip>
        <identifiers>
          <isin value="US01671P1003"/>
        </identifiers>
        <balance>489529.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>41791090.73000000</valUSD>
        <pctVal>0.567573380950</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="7084015.80000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cortexyme Inc</name>
        <lei>N/A</lei>
        <title>Cortexyme Inc</title>
        <cusip>22053A107</cusip>
        <identifiers>
          <isin value="US22053A1079"/>
        </identifiers>
        <balance>634721.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>33640213.00000000</valUSD>
        <pctVal>0.456874637507</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="26439266.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Replimune Group Inc</name>
        <lei>549300AY704NEIRC4K64</lei>
        <title>Replimune Group Inc</title>
        <cusip>76029N106</cusip>
        <identifiers>
          <isin value="US76029N1063"/>
        </identifiers>
        <balance>1205842.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46328449.64000000</valUSD>
        <pctVal>0.629196183613</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IGM Biosciences Inc</name>
        <lei>5493008XCQES2N0VY969</lei>
        <title>IGM Biosciences Inc</title>
        <cusip>449585108</cusip>
        <identifiers>
          <isin value="US4495851085"/>
        </identifiers>
        <balance>452899.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>37681196.80000000</valUSD>
        <pctVal>0.511756067919</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1478297.60000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Veracyte Inc</name>
        <lei>529900ESWZRHXOW27Z37</lei>
        <title>Veracyte Inc</title>
        <cusip>92337F107</cusip>
        <identifiers>
          <isin value="US92337F1075"/>
        </identifiers>
        <balance>1272057.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>50856838.86000000</valUSD>
        <pctVal>0.690697167075</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vaxcyte Inc</name>
        <lei>254900M7NMHTGASX8D95</lei>
        <title>Vaxcyte Inc</title>
        <cusip>92243G108</cusip>
        <identifiers>
          <isin value="US92243G1085"/>
        </identifiers>
        <balance>932356.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>20987333.56000000</valUSD>
        <pctVal>0.285033284791</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="9014558.18000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sorrento Therapeutics Inc</name>
        <lei>549300RH23PRR3M13410</lei>
        <title>Sorrento Therapeutics Inc</title>
        <cusip>83587F202</cusip>
        <identifiers>
          <isin value="US83587F2020"/>
        </identifiers>
        <balance>5182720.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>50220556.80000000</valUSD>
        <pctVal>0.682055689820</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="28026982.18000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Blueprint Medicines Corp</name>
        <lei>5299004CC60O9T5HVM83</lei>
        <title>Blueprint Medicines Corp</title>
        <cusip>09627Y109</cusip>
        <identifiers>
          <isin value="US09627Y1091"/>
        </identifiers>
        <balance>528989.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46529872.44000000</valUSD>
        <pctVal>0.631931748003</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Athenex Inc</name>
        <lei>5493001V4L0Q5EPPOH52</lei>
        <title>Athenex Inc</title>
        <cusip>04685N103</cusip>
        <identifiers>
          <isin value="US04685N1037"/>
        </identifiers>
        <balance>7180138.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>33172237.56000000</valUSD>
        <pctVal>0.450518967003</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="11556331.64000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Morphic Holding Inc</name>
        <lei>549300RWWOUFLHTY1224</lei>
        <title>Morphic Holding Inc</title>
        <cusip>61775R105</cusip>
        <identifiers>
          <isin value="US61775R1059"/>
        </identifiers>
        <balance>513957.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>29495992.23000000</valUSD>
        <pctVal>0.400591124616</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Rigel Pharmaceuticals Inc</name>
        <lei>529900KPTNUS5J8K9K66</lei>
        <title>Rigel Pharmaceuticals Inc</title>
        <cusip>766559603</cusip>
        <identifiers>
          <isin value="US7665596034"/>
        </identifiers>
        <balance>7262187.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>31517891.58000000</valUSD>
        <pctVal>0.428050954689</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="12015264.14000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CareDx Inc</name>
        <lei>549300NQOFKL9NON0U06</lei>
        <title>CareDx Inc</title>
        <cusip>14167L103</cusip>
        <identifiers>
          <isin value="US14167L1035"/>
        </identifiers>
        <balance>503795.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46107318.40000000</valUSD>
        <pctVal>0.626192954855</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Bridgebio Pharma Inc</name>
        <lei>54930028YG89VTY2J114</lei>
        <title>Bridgebio Pharma Inc</title>
        <cusip>10806X102</cusip>
        <identifiers>
          <isin value="US10806X1028"/>
        </identifiers>
        <balance>719025.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43831764.00000000</valUSD>
        <pctVal>0.595288183484</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="36082991.52000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BioAtla Inc</name>
        <lei>N/A</lei>
        <title>BioAtla Inc</title>
        <cusip>09077B104</cusip>
        <identifiers>
          <isin value="US09077B1044"/>
        </identifiers>
        <balance>448727.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19017050.26000000</valUSD>
        <pctVal>0.258274462887</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Prothena Corp PLC</name>
        <lei>5299009ZXQ8NIIJ8OL30</lei>
        <title>Prothena Corp PLC</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="IE00B91XRN20"/>
        </identifiers>
        <balance>602372.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>30967944.52000000</valUSD>
        <pctVal>0.420582010789</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="6343994.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Kodiak Sciences Inc</name>
        <lei>254900IXI5NI8C9OQE24</lei>
        <title>Kodiak Sciences Inc</title>
        <cusip>50015M109</cusip>
        <identifiers>
          <isin value="US50015M1099"/>
        </identifiers>
        <balance>549774.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>51128982.00000000</valUSD>
        <pctVal>0.694393198918</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="30438379.71000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MacroGenics Inc</name>
        <lei>5493001KJQUA83L8MH79</lei>
        <title>MacroGenics Inc</title>
        <cusip>556099109</cusip>
        <identifiers>
          <isin value="US5560991094"/>
        </identifiers>
        <balance>2155199.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>57888645.14000000</valUSD>
        <pctVal>0.786197571463</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="67230.58000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Kymera Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Kymera Therapeutics Inc</title>
        <cusip>501575104</cusip>
        <identifiers>
          <isin value="US5015751044"/>
        </identifiers>
        <balance>909382.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>44105027.00000000</valUSD>
        <pctVal>0.598999424375</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Stoke Therapeutics Inc</name>
        <lei>549300RD25SS2DIJHJ67</lei>
        <title>Stoke Therapeutics Inc</title>
        <cusip>86150R107</cusip>
        <identifiers>
          <isin value="US86150R1077"/>
        </identifiers>
        <balance>577973.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19454571.18000000</valUSD>
        <pctVal>0.264216524304</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="555426.26000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Dynavax Technologies Corp</name>
        <lei>549300T5URIXWDILX594</lei>
        <title>Dynavax Technologies Corp</title>
        <cusip>268158201</cusip>
        <identifiers>
          <isin value="US2681582019"/>
        </identifiers>
        <balance>5007691.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>49325756.35000000</valUSD>
        <pctVal>0.669903221248</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="33306539.61000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cue Biopharma Inc</name>
        <lei>549300PBW78KZA33WC97</lei>
        <title>Cue Biopharma Inc</title>
        <cusip>22978P106</cusip>
        <identifiers>
          <isin value="US22978P1066"/>
        </identifiers>
        <balance>926111.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10789193.15000000</valUSD>
        <pctVal>0.146530246684</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="713033.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Deciphera Pharmaceuticals Inc</name>
        <lei>529900QR4WAPYY0CBF25</lei>
        <title>Deciphera Pharmaceuticals Inc</title>
        <cusip>24344T101</cusip>
        <identifiers>
          <isin value="US24344T1016"/>
        </identifiers>
        <balance>1297855.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>47514471.55000000</valUSD>
        <pctVal>0.645303790607</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="234688.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IVERIC bio Inc</name>
        <lei>549300GZXI59U71XPM70</lei>
        <title>IVERIC bio Inc</title>
        <cusip>46583P102</cusip>
        <identifiers>
          <isin value="US46583P1021"/>
        </identifiers>
        <balance>1680769.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10605652.39000000</valUSD>
        <pctVal>0.144037541950</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Global Blood Therapeutics Inc</name>
        <lei>549300U4G0QKK99GRT15</lei>
        <title>Global Blood Therapeutics Inc</title>
        <cusip>37890U108</cusip>
        <identifiers>
          <isin value="US37890U1088"/>
        </identifiers>
        <balance>1131157.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>39613118.14000000</valUSD>
        <pctVal>0.537993888170</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4937995.10000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ardelyx Inc</name>
        <lei>549300F542QR4SXHCY32</lei>
        <title>Ardelyx Inc</title>
        <cusip>039697107</cusip>
        <identifiers>
          <isin value="US0396971071"/>
        </identifiers>
        <balance>4923091.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>37317029.78000000</valUSD>
        <pctVal>0.506810240874</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4931056.12000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TG Therapeutics Inc</name>
        <lei>529900X21UKABN9NJ529</lei>
        <title>TG Therapeutics Inc</title>
        <cusip>88322Q108</cusip>
        <identifiers>
          <isin value="US88322Q1085"/>
        </identifiers>
        <balance>1217108.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>47211619.32000000</valUSD>
        <pctVal>0.641190692310</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="24294126.95000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sarepta Therapeutics Inc</name>
        <lei>549300IKDPIED8J8IG21</lei>
        <title>Sarepta Therapeutics Inc</title>
        <cusip>803607100</cusip>
        <identifiers>
          <isin value="US8036071004"/>
        </identifiers>
        <balance>534576.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>41557938.24000000</valUSD>
        <pctVal>0.564406889128</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="18123954.10000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Aldeyra Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Aldeyra Therapeutics Inc</title>
        <cusip>01438T106</cusip>
        <identifiers>
          <isin value="US01438T1060"/>
        </identifiers>
        <balance>2351332.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>26640591.56000000</valUSD>
        <pctVal>0.361811342037</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1818754.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ACHILLION PHARMACE</name>
        <lei>529900LZPJ796VSWZM38</lei>
        <title>ACHILLION PHARMACE</title>
        <cusip>004CVR031</cusip>
        <identifiers>
          <isin value="US004CVR0317"/>
        </identifiers>
        <balance>51865.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>75463.58000000</valUSD>
        <pctVal>0.001024886369</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerConditional desc="derivative" issuerCat="OTHER"/>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <derivativeInfo>
          <othDeriv derivCat="OTH" othDesc="rights">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
            </counterparties>
            <descRefInstrmnt>
              <otherRefInst>
                <issuerName>Achillion Pharmaceuticals Inc</issuerName>
                <issueTitle>Achillion Pharmaceuticals Inc</issueTitle>
                <identifiers>
                  <cusip value="00448Q201"/>
                  <isin value="US00448Q2012"/>
                </identifiers>
              </otherRefInst>
            </descRefInstrmnt>
            <terminationDt>2024-07-29</terminationDt>
            <notionalAmts>
              <notionalAmt amt="51865.00000000" curCd="USD"/>
            </notionalAmts>
            <delta>XXXX</delta>
            <unrealizedAppr>51605.68000000</unrealizedAppr>
          </othDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="62311.80000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FibroGen Inc</name>
        <lei>549300Q914ULWWY95822</lei>
        <title>FibroGen Inc</title>
        <cusip>31572Q808</cusip>
        <identifiers>
          <isin value="US31572Q8087"/>
        </identifiers>
        <balance>1764051.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46976678.13000000</valUSD>
        <pctVal>0.637999907787</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="18951932.11000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Gossamer Bio Inc</name>
        <lei>549300ZOC0N2W6PSFR58</lei>
        <title>Gossamer Bio Inc</title>
        <cusip>38341P102</cusip>
        <identifiers>
          <isin value="US38341P1021"/>
        </identifiers>
        <balance>1988772.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16148828.64000000</valUSD>
        <pctVal>0.219320556355</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="11859627.48000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sangamo Therapeutics Inc</name>
        <lei>2549006WMRKRC4G32Z67</lei>
        <title>Sangamo Therapeutics Inc</title>
        <cusip>800677106</cusip>
        <identifiers>
          <isin value="US8006771062"/>
        </identifiers>
        <balance>3684368.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>44101884.96000000</valUSD>
        <pctVal>0.598956751685</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="15784307.70000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Puma Biotechnology Inc</name>
        <lei>N/A</lei>
        <title>Puma Biotechnology Inc</title>
        <cusip>74587V107</cusip>
        <identifiers>
          <isin value="US74587V1070"/>
        </identifiers>
        <balance>901221.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8273208.78000000</valUSD>
        <pctVal>0.112360146542</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4370550.64000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Heron Therapeutics Inc</name>
        <lei>549300DR2I1DOPD2IX53</lei>
        <title>Heron Therapeutics Inc</title>
        <cusip>427746102</cusip>
        <identifiers>
          <isin value="US4277461020"/>
        </identifiers>
        <balance>2985073.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46328332.96000000</valUSD>
        <pctVal>0.629194598958</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="27167290.04000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ultragenyx Pharmaceutical Inc</name>
        <lei>529900EV44GVDN1DCX77</lei>
        <title>Ultragenyx Pharmaceutical Inc</title>
        <cusip>90400D108</cusip>
        <identifiers>
          <isin value="US90400D1081"/>
        </identifiers>
        <balance>451987.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43096960.45000000</valUSD>
        <pctVal>0.585308665651</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="28605.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Insmed Inc</name>
        <lei>529900Q55QAG41CCAC11</lei>
        <title>Insmed Inc</title>
        <cusip>457669307</cusip>
        <identifiers>
          <isin value="US4576693075"/>
        </identifiers>
        <balance>1529249.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43522426.54000000</valUSD>
        <pctVal>0.591087007947</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="182144.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Arcus Biosciences Inc</name>
        <lei>N/A</lei>
        <title>Arcus Biosciences Inc</title>
        <cusip>03969F109</cusip>
        <identifiers>
          <isin value="US03969F1093"/>
        </identifiers>
        <balance>1846990.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>50718345.40000000</valUSD>
        <pctVal>0.688816258969</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Constellation Pharmaceuticals Inc</name>
        <lei>N/A</lei>
        <title>Constellation Pharmaceuticals Inc</title>
        <cusip>210373106</cusip>
        <identifiers>
          <isin value="US2103731061"/>
        </identifiers>
        <balance>979745.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>33115381.00000000</valUSD>
        <pctVal>0.449746786391</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="184108.60000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Arcutis Biotherapeutics Inc</name>
        <lei>N/A</lei>
        <title>Arcutis Biotherapeutics Inc</title>
        <cusip>03969K108</cusip>
        <identifiers>
          <isin value="US03969K1088"/>
        </identifiers>
        <balance>665526.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18162204.54000000</valUSD>
        <pctVal>0.246664627704</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2442410.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vir Biotechnology Inc</name>
        <lei>N/A</lei>
        <title>Vir Biotechnology Inc</title>
        <cusip>92764N102</cusip>
        <identifiers>
          <isin value="US92764N1028"/>
        </identifiers>
        <balance>1009657.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>47736582.96000000</valUSD>
        <pctVal>0.648320331256</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="17006512.80000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vericel Corp</name>
        <lei>54930076YM3PLTDR4B91</lei>
        <title>Vericel Corp</title>
        <cusip>92346J108</cusip>
        <identifiers>
          <isin value="US92346J1088"/>
        </identifiers>
        <balance>798349.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>41913322.50000000</valUSD>
        <pctVal>0.569233435707</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="11266361.49000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Radius Health Inc</name>
        <lei>549300EV6I2M6E0YVT27</lei>
        <title>Radius Health Inc</title>
        <cusip>750469207</cusip>
        <identifiers>
          <isin value="US7504692077"/>
        </identifiers>
        <balance>1413887.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>25789298.88000000</valUSD>
        <pctVal>0.350249761419</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="20311930.02000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Altimmune Inc</name>
        <lei>549300EOYCQ8SW3NVE64</lei>
        <title>Altimmune Inc</title>
        <cusip>02155H200</cusip>
        <identifiers>
          <isin value="US02155H2004"/>
        </identifiers>
        <balance>3199090.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>31511036.50000000</valUSD>
        <pctVal>0.427957854440</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALX Oncology Holdings Inc</name>
        <lei>N/A</lei>
        <title>ALX Oncology Holdings Inc</title>
        <cusip>00166B105</cusip>
        <identifiers>
          <isin value="US00166B1052"/>
        </identifiers>
        <balance>770538.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>42133017.84000000</valUSD>
        <pctVal>0.572217163212</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Emergent BioSolutions Inc</name>
        <lei>549300YW6TUOX8BE5103</lei>
        <title>Emergent BioSolutions Inc</title>
        <cusip>29089Q105</cusip>
        <identifiers>
          <isin value="US29089Q1058"/>
        </identifiers>
        <balance>723805.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>45592476.95000000</valUSD>
        <pctVal>0.619200787450</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="63495.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Natera Inc</name>
        <lei>N/A</lei>
        <title>Natera Inc</title>
        <cusip>632307104</cusip>
        <identifiers>
          <isin value="US6323071042"/>
        </identifiers>
        <balance>442552.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>50242928.56000000</valUSD>
        <pctVal>0.682359525284</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2963133.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Neurocrine Biosciences Inc</name>
        <lei>549300FECER0XBN49756</lei>
        <title>Neurocrine Biosciences Inc</title>
        <cusip>64125C109</cusip>
        <identifiers>
          <isin value="US64125C1099"/>
        </identifiers>
        <balance>466167.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>45367372.44000000</valUSD>
        <pctVal>0.616143596896</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Exelixis Inc</name>
        <lei>254900PJQB59O2O95R37</lei>
        <title>Exelixis Inc</title>
        <cusip>30161Q104</cusip>
        <identifiers>
          <isin value="US30161Q1040"/>
        </identifiers>
        <balance>2000443.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>36448071.46000000</valUSD>
        <pctVal>0.495008739573</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4745980.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Prelude Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Prelude Therapeutics Inc</title>
        <cusip>74065P101</cusip>
        <identifiers>
          <isin value="US74065P1012"/>
        </identifiers>
        <balance>877293.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>25116898.59000000</valUSD>
        <pctVal>0.341117755069</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4899726.56000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Editas Medicine Inc</name>
        <lei>5299000AON4Q9NT2JE42</lei>
        <title>Editas Medicine Inc</title>
        <cusip>28106W103</cusip>
        <identifiers>
          <isin value="US28106W1036"/>
        </identifiers>
        <balance>1228459.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>69579917.76000000</valUSD>
        <pctVal>0.944979144584</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="38472489.46000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Forma Therapeutics Holdings Inc</name>
        <lei>N/A</lei>
        <title>Forma Therapeutics Holdings Inc</title>
        <cusip>34633R104</cusip>
        <identifiers>
          <isin value="US34633R1041"/>
        </identifiers>
        <balance>1675894.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>41713001.66000000</valUSD>
        <pctVal>0.566512837262</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="11877751.98000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VBI Vaccines Inc</name>
        <lei>N/A</lei>
        <title>VBI Vaccines Inc</title>
        <cusip>91822J103</cusip>
        <identifiers>
          <isin value="CA91822J1030"/>
        </identifiers>
        <balance>9098600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>30480310.00000000</valUSD>
        <pctVal>0.413959346284</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="25199773.79000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cytokinetics Inc</name>
        <lei>549300BE5DY1HW7IHA64</lei>
        <title>Cytokinetics Inc</title>
        <cusip>23282W605</cusip>
        <identifiers>
          <isin value="US23282W6057"/>
        </identifiers>
        <balance>2184913.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43239428.27000000</valUSD>
        <pctVal>0.587243550356</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3752960.64000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Chimerix Inc</name>
        <lei>5299002IR2GXUBEPKS66</lei>
        <title>Chimerix Inc</title>
        <cusip>16934W106</cusip>
        <identifiers>
          <isin value="US16934W1062"/>
        </identifiers>
        <balance>1875761.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>15006088.00000000</valUSD>
        <pctVal>0.203800761172</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Regeneron Pharmaceuticals Inc</name>
        <lei>549300RCBFWIRX3HYQ56</lei>
        <title>Regeneron Pharmaceuticals Inc</title>
        <cusip>75886F107</cusip>
        <identifiers>
          <isin value="US75886F1075"/>
        </identifiers>
        <balance>87481.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>48861637.74000000</valUSD>
        <pctVal>0.663599931144</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Nurix Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Nurix Therapeutics Inc</title>
        <cusip>67080M103</cusip>
        <identifiers>
          <isin value="US67080M1036"/>
        </identifiers>
        <balance>1386822.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>36792387.66000000</valUSD>
        <pctVal>0.499684968558</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="16778901.29000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Syndax Pharmaceuticals Inc</name>
        <lei>529900OF94TRHKZVBS87</lei>
        <title>Syndax Pharmaceuticals Inc</title>
        <cusip>87164F105</cusip>
        <identifiers>
          <isin value="US87164F1057"/>
        </identifiers>
        <balance>2435058.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>41809945.86000000</valUSD>
        <pctVal>0.567829456341</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="13508558.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>OPKO Health Inc</name>
        <lei>529900A4S2D4OGOJLL02</lei>
        <title>OPKO Health Inc</title>
        <cusip>68375N103</cusip>
        <identifiers>
          <isin value="US68375N1037"/>
        </identifiers>
        <balance>12357691.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>50048648.55000000</valUSD>
        <pctVal>0.679720968592</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="33969030.81000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>REGENXBIO Inc</name>
        <lei>549300EOES47LATSET33</lei>
        <title>REGENXBIO Inc</title>
        <cusip>75901B107</cusip>
        <identifiers>
          <isin value="US75901B1070"/>
        </identifiers>
        <balance>1129413.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43877695.05000000</valUSD>
        <pctVal>0.595911982502</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Immunovant Inc</name>
        <lei>N/A</lei>
        <title>Immunovant Inc</title>
        <cusip>45258J102</cusip>
        <identifiers>
          <isin value="US45258J1025"/>
        </identifiers>
        <balance>3651329.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>38594547.53000000</valUSD>
        <pctVal>0.524160471651</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3106147.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Biohaven Pharmaceutical Holding Co Ltd</name>
        <lei>5299007STZTNN32O9920</lei>
        <title>Biohaven Pharmaceutical Holding Co Ltd</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="VGG111961055"/>
        </identifiers>
        <balance>437773.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>42499002.84000000</valUSD>
        <pctVal>0.577187680617</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>VG</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Arena Pharmaceuticals Inc</name>
        <lei>529900CVGQMPJ3A3NI85</lei>
        <title>Arena Pharmaceuticals Inc</title>
        <cusip>040047607</cusip>
        <identifiers>
          <isin value="US0400476075"/>
        </identifiers>
        <balance>705177.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>48093071.40000000</valUSD>
        <pctVal>0.653161873930</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Rocket Pharmaceuticals Inc</name>
        <lei>549300R7VV82YUIN4Y93</lei>
        <title>Rocket Pharmaceuticals Inc</title>
        <cusip>77313F106</cusip>
        <identifiers>
          <isin value="US77313F1066"/>
        </identifiers>
        <balance>995474.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>44089543.46000000</valUSD>
        <pctVal>0.598789139240</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="21930927.87000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Atara Biotherapeutics Inc</name>
        <lei>549300WBXUXZRE03MS38</lei>
        <title>Atara Biotherapeutics Inc</title>
        <cusip>046513107</cusip>
        <identifiers>
          <isin value="US0465131078"/>
        </identifiers>
        <balance>2786142.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43324508.10000000</valUSD>
        <pctVal>0.588399036990</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="164830.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Coherus Biosciences Inc</name>
        <lei>5493007IL8W5MV932D26</lei>
        <title>Coherus Biosciences Inc</title>
        <cusip>19249H103</cusip>
        <identifiers>
          <isin value="US19249H1032"/>
        </identifiers>
        <balance>3170404.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43846687.32000000</valUSD>
        <pctVal>0.595490860156</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1776360.24000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Neoleukin Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Neoleukin Therapeutics Inc</title>
        <cusip>64049K104</cusip>
        <identifiers>
          <isin value="US64049K1043"/>
        </identifiers>
        <balance>639054.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5898468.42000000</valUSD>
        <pctVal>0.080108310290</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Applied Molecular Transport Inc</name>
        <lei>N/A</lei>
        <title>Applied Molecular Transport Inc</title>
        <cusip>03824M109</cusip>
        <identifiers>
          <isin value="US03824M1099"/>
        </identifiers>
        <balance>835426.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>38212385.24000000</valUSD>
        <pctVal>0.518970247150</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="9250589.66000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alkermes PLC</name>
        <lei>N/A</lei>
        <title>Alkermes PLC</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="IE00B56GVS15"/>
        </identifiers>
        <balance>1836616.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>45033824.32000000</valUSD>
        <pctVal>0.611613611416</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alexion Pharmaceuticals Inc</name>
        <lei>M1YXUUZR0EIMU8T0EM75</lei>
        <title>Alexion Pharmaceuticals Inc</title>
        <cusip>015351109</cusip>
        <identifiers>
          <isin value="US0153511094"/>
        </identifiers>
        <balance>253114.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46499572.94000000</valUSD>
        <pctVal>0.631520244274</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Amicus Therapeutics Inc</name>
        <lei>549300MRD1SMUTNBPQ53</lei>
        <title>Amicus Therapeutics Inc</title>
        <cusip>03152W109</cusip>
        <identifiers>
          <isin value="US03152W1099"/>
        </identifiers>
        <balance>4328715.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>41728812.60000000</valUSD>
        <pctVal>0.566727568884</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Flexion Therapeutics Inc</name>
        <lei>549300X8HYW1HZKCDG90</lei>
        <title>Flexion Therapeutics Inc</title>
        <cusip>33938J106</cusip>
        <identifiers>
          <isin value="US33938J1060"/>
        </identifiers>
        <balance>3076590.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>25320335.70000000</valUSD>
        <pctVal>0.343880676216</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="231439.27000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>C4 Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>C4 Therapeutics Inc</title>
        <cusip>12529R107</cusip>
        <identifiers>
          <isin value="US12529R1077"/>
        </identifiers>
        <balance>860616.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>32565709.44000000</valUSD>
        <pctVal>0.442281584113</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3881778.56000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Scholar Rock Holding Corp</name>
        <lei>549300Z1FLPGL4OWJ459</lei>
        <title>Scholar Rock Holding Corp</title>
        <cusip>80706P103</cusip>
        <identifiers>
          <isin value="US80706P1030"/>
        </identifiers>
        <balance>1242761.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>35915792.90000000</valUSD>
        <pctVal>0.487779755198</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1910997.70000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PTC Therapeutics Inc</name>
        <lei>549300UJLWOIWFDGB318</lei>
        <title>PTC Therapeutics Inc</title>
        <cusip>69366J200</cusip>
        <identifiers>
          <isin value="US69366J2006"/>
        </identifiers>
        <balance>1070350.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>45243694.50000000</valUSD>
        <pctVal>0.614463901408</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="756633.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Novavax Inc</name>
        <lei>529900J4GJHPEPQ23205</lei>
        <title>Novavax Inc</title>
        <cusip>670002401</cusip>
        <identifiers>
          <isin value="US6700024010"/>
        </identifiers>
        <balance>219240.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46546844.40000000</valUSD>
        <pctVal>0.632162247675</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4703303.43000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Karyopharm Therapeutics Inc</name>
        <lei>549300J1VANRCNTYST87</lei>
        <title>Karyopharm Therapeutics Inc</title>
        <cusip>48576U106</cusip>
        <identifiers>
          <isin value="US48576U1060"/>
        </identifiers>
        <balance>4454512.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>45970563.84000000</valUSD>
        <pctVal>0.624335663106</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="16782091.85000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SpringWorks Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>SpringWorks Therapeutics Inc</title>
        <cusip>85205L107</cusip>
        <identifiers>
          <isin value="US85205L1070"/>
        </identifiers>
        <balance>559270.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46089440.70000000</valUSD>
        <pctVal>0.625950154142</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="391200.27000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>uniQure NV</name>
        <lei>N/A</lei>
        <title>uniQure NV</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="NL0010696654"/>
        </identifiers>
        <balance>1274840.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>39265072.00000000</valUSD>
        <pctVal>0.533267002105</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="154000.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Annexon Inc</name>
        <lei>N/A</lei>
        <title>Annexon Inc</title>
        <cusip>03589W102</cusip>
        <identifiers>
          <isin value="US03589W1027"/>
        </identifiers>
        <balance>488482.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10995729.82000000</valUSD>
        <pctVal>0.149335263591</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Xencor Inc</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>Xencor Inc</title>
        <cusip>98401F105</cusip>
        <identifiers>
          <isin value="US98401F1057"/>
        </identifiers>
        <balance>847905.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>29244243.45000000</valUSD>
        <pctVal>0.397172072762</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4005888.48000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Allogene Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Allogene Therapeutics Inc</title>
        <cusip>019770106</cusip>
        <identifiers>
          <isin value="US0197701065"/>
        </identifiers>
        <balance>1761307.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>45934886.56000000</valUSD>
        <pctVal>0.623851122644</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="899160.16000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>State Street Global Advisors</name>
        <lei>5493000HFJPORCLSV250</lei>
        <title>State Street Institutional Liquid Reserves Fund</title>
        <cusip>85749P101</cusip>
        <identifiers>
          <isin value="US85749P1012"/>
        </identifiers>
        <balance>6614369.15000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6616353.46000000</valUSD>
        <pctVal>0.089858054366</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Agenus Inc</name>
        <lei>529900NDQQGU5H4UJK81</lei>
        <title>Agenus Inc</title>
        <cusip>00847G705</cusip>
        <identifiers>
          <isin value="US00847G7051"/>
        </identifiers>
        <balance>7395817.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>40603035.33000000</valUSD>
        <pctVal>0.551438156711</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2264773.23000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Gilead Sciences Inc</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>Gilead Sciences Inc</title>
        <cusip>375558103</cusip>
        <identifiers>
          <isin value="US3755581036"/>
        </identifiers>
        <balance>668478.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46031395.08000000</valUSD>
        <pctVal>0.625161824662</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MannKind Corp</name>
        <lei>213800GFBCNY1ZFST722</lei>
        <title>MannKind Corp</title>
        <cusip>56400P706</cusip>
        <identifiers>
          <isin value="US56400P7069"/>
        </identifiers>
        <balance>11350720.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>61861424.00000000</valUSD>
        <pctVal>0.840152696586</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="52742845.85000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zentalis Pharmaceuticals Inc</name>
        <lei>N/A</lei>
        <title>Zentalis Pharmaceuticals Inc</title>
        <cusip>98943L107</cusip>
        <identifiers>
          <isin value="US98943L1070"/>
        </identifiers>
        <balance>818547.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43546700.40000000</valUSD>
        <pctVal>0.591416676222</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2388680.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CEL-SCI Corp</name>
        <lei>549300FIWOFSETIVMI17</lei>
        <title>CEL-SCI Corp</title>
        <cusip>150837607</cusip>
        <identifiers>
          <isin value="US1508376076"/>
        </identifiers>
        <balance>2069858.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17966367.44000000</valUSD>
        <pctVal>0.244004923853</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="15174141.64000000"/>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>



    </explntrNotes>
    <signature>
      <ncom:dateSigned>2021-07-28</ncom:dateSigned>
      <ncom:nameOfApplicant>SPDR SERIES TRUST</ncom:nameOfApplicant>
      <ncom:signature>Arthur Jensen</ncom:signature>
      <ncom:signerName>Arthur Jensen</ncom:signerName>
      <ncom:title>Deputy Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
