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        <name>Invitae Corp</name>
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        <name>Kadmon Holdings Inc</name>
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        <name>Intellia Therapeutics Inc</name>
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        <name>Halozyme Therapeutics Inc</name>
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        <curCd>USD</curCd>
        <valUSD>11230569.95000000</valUSD>
        <pctVal>0.159510940130</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PTC Therapeutics Inc</name>
        <lei>549300UJLWOIWFDGB318</lei>
        <title>PTC Therapeutics Inc</title>
        <cusip>69366J200</cusip>
        <identifiers>
          <isin value="US69366J2006"/>
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        <balance>982179.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>59942384.37000000</valUSD>
        <pctVal>0.851378525496</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="213605.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Novavax Inc</name>
        <lei>529900J4GJHPEPQ23205</lei>
        <title>Novavax Inc</title>
        <cusip>670002401</cusip>
        <identifiers>
          <isin value="US6700024010"/>
        </identifiers>
        <balance>511095.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>56992203.45000000</valUSD>
        <pctVal>0.809476277062</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="52612112.25000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Karyopharm Therapeutics Inc</name>
        <lei>549300J1VANRCNTYST87</lei>
        <title>Karyopharm Therapeutics Inc</title>
        <cusip>48576U106</cusip>
        <identifiers>
          <isin value="US48576U1060"/>
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        <balance>4034744.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>62457837.12000000</valUSD>
        <pctVal>0.887106207599</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="18173534.76000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SpringWorks Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>SpringWorks Therapeutics Inc</title>
        <cusip>85205L107</cusip>
        <identifiers>
          <isin value="US85205L1070"/>
        </identifiers>
        <balance>632358.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>45858602.16000000</valUSD>
        <pctVal>0.651342610052</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="32574202.44000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>uniQure NV</name>
        <lei>N/A</lei>
        <title>uniQure NV</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="NL0010696654"/>
        </identifiers>
        <balance>999388.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>36107888.44000000</valUSD>
        <pctVal>0.512850483709</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="26012.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Xencor Inc</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>Xencor Inc</title>
        <cusip>98401F105</cusip>
        <identifiers>
          <isin value="US98401F1057"/>
        </identifiers>
        <balance>811620.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>35410980.60000000</valUSD>
        <pctVal>0.502952105867</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5767299.26000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Allogene Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Allogene Therapeutics Inc</title>
        <cusip>019770106</cusip>
        <identifiers>
          <isin value="US0197701065"/>
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        <balance>2327499.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>58746074.76000000</valUSD>
        <pctVal>0.834387004012</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="45080331.08000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Black Diamond Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Black Diamond Therapeutics Inc</title>
        <cusip>09203E105</cusip>
        <identifiers>
          <isin value="US09203E1055"/>
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        <balance>531362.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17030152.10000000</valUSD>
        <pctVal>0.241884034748</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1059988.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>State Street Global Advisors</name>
        <lei>5493000HFJPORCLSV250</lei>
        <title>State Street Institutional Liquid Reserves Fund</title>
        <cusip>85749P101</cusip>
        <identifiers>
          <isin value="US85749P1012"/>
        </identifiers>
        <balance>1207088.19000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1207329.61000000</valUSD>
        <pctVal>0.017148041639</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Agenus Inc</name>
        <lei>529900NDQQGU5H4UJK81</lei>
        <title>Agenus Inc</title>
        <cusip>00847G705</cusip>
        <identifiers>
          <isin value="US00847G7051"/>
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        <balance>7469252.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>23752221.36000000</valUSD>
        <pctVal>0.337359472955</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4596766.32000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Gilead Sciences Inc</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>Gilead Sciences Inc</title>
        <cusip>375558103</cusip>
        <identifiers>
          <isin value="US3755581036"/>
        </identifiers>
        <balance>1050336.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>61192575.36000000</valUSD>
        <pctVal>0.869135339357</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MannKind Corp</name>
        <lei>213800GFBCNY1ZFST722</lei>
        <title>MannKind Corp</title>
        <cusip>56400P706</cusip>
        <identifiers>
          <isin value="US56400P7069"/>
        </identifiers>
        <balance>5173452.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16192904.76000000</valUSD>
        <pctVal>0.229992375561</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3243617.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zentalis Pharmaceuticals Inc</name>
        <lei>N/A</lei>
        <title>Zentalis Pharmaceuticals Inc</title>
        <cusip>98943L107</cusip>
        <identifiers>
          <isin value="US98943L1070"/>
        </identifiers>
        <balance>421222.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>21878270.68000000</valUSD>
        <pctVal>0.310743224977</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="465642.10000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CEL-SCI Corp</name>
        <lei>549300FIWOFSETIVMI17</lei>
        <title>CEL-SCI Corp</title>
        <cusip>150837607</cusip>
        <identifiers>
          <isin value="US1508376076"/>
        </identifiers>
        <balance>1363125.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>15894037.50000000</valUSD>
        <pctVal>0.225747479903</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="13459196.30000000"/>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>



    </explntrNotes>
    <signature>
      <ncom:dateSigned>2021-01-19</ncom:dateSigned>
      <ncom:nameOfApplicant>SPDR SERIES TRUST</ncom:nameOfApplicant>
      <ncom:signature>Daniel Foley</ncom:signature>
      <ncom:signerName>Daniel Foley</ncom:signerName>
      <ncom:title>Assistant Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
