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        <title>Atara Biotherapeutics Inc</title>
        <cusip>046513107</cusip>
        <identifiers>
          <isin value="US0465131078"/>
        </identifiers>
        <balance>1749839.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>22677913.44000000</valUSD>
        <pctVal>0.432670348538</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="7054461.60000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Lantheus Holdings Inc</name>
        <lei>5299005HUB5IOJGO7S39</lei>
        <title>Lantheus Holdings Inc</title>
        <cusip>516544103</cusip>
        <identifiers>
          <isin value="US5165441032"/>
        </identifiers>
        <balance>2.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>25.34000000</valUSD>
        <pctVal>0.000000483460</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="12.67000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Insmed Inc</name>
        <lei>529900Q55QAG41CCAC11</lei>
        <title>Insmed Inc</title>
        <cusip>457669307</cusip>
        <identifiers>
          <isin value="US4576693075"/>
        </identifiers>
        <balance>1709427.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>54940983.78000000</valUSD>
        <pctVal>1.048215245376</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="724210.62000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Madrigal Pharmaceuticals Inc</name>
        <lei>549300CHIMT2EUSNJB60</lei>
        <title>Madrigal Pharmaceuticals Inc</title>
        <cusip>558868105</cusip>
        <identifiers>
          <isin value="US5588681057"/>
        </identifiers>
        <balance>257707.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>30597552.11000000</valUSD>
        <pctVal>0.583768589243</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2995320.44000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Kadmon Holdings Inc</name>
        <lei>549300BBVICD23L50606</lei>
        <title>Kadmon Holdings Inc</title>
        <cusip>48283N106</cusip>
        <identifiers>
          <isin value="US48283N1063"/>
        </identifiers>
        <balance>5454123.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>21380162.16000000</valUSD>
        <pctVal>0.407910641252</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="64178.24000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Regeneron Pharmaceuticals Inc</name>
        <lei>549300RCBFWIRX3HYQ56</lei>
        <title>Regeneron Pharmaceuticals Inc</title>
        <cusip>75886F107</cusip>
        <identifiers>
          <isin value="US75886F1075"/>
        </identifiers>
        <balance>89328.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>50004027.84000000</valUSD>
        <pctVal>0.954023403039</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Karuna Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Karuna Therapeutics Inc</title>
        <cusip>48576A100</cusip>
        <identifiers>
          <isin value="US48576A1007"/>
        </identifiers>
        <balance>498444.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>38539690.08000000</valUSD>
        <pctVal>0.735296092543</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="11409661.84000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Arena Pharmaceuticals Inc</name>
        <lei>529900CVGQMPJ3A3NI85</lei>
        <title>Arena Pharmaceuticals Inc</title>
        <cusip>040047607</cusip>
        <identifiers>
          <isin value="US0400476075"/>
        </identifiers>
        <balance>768104.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>57446498.16000000</valUSD>
        <pctVal>1.096017781660</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Arcturus Therapeutics Holdings Inc</name>
        <lei>N/A</lei>
        <title>Arcturus Therapeutics Holdings Inc</title>
        <cusip>03969T109</cusip>
        <identifiers>
          <isin value="US03969T1097"/>
        </identifiers>
        <balance>1260983.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>54096170.70000000</valUSD>
        <pctVal>1.032097114811</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="31023440.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sage Therapeutics Inc</name>
        <lei>5493000JX4BJS9W6CN35</lei>
        <title>Sage Therapeutics Inc</title>
        <cusip>78667J108</cusip>
        <identifiers>
          <isin value="US78667J1088"/>
        </identifiers>
        <balance>873358.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>53379640.96000000</valUSD>
        <pctVal>1.018426493254</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="23085546.36000000"/>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>



    </explntrNotes>
    <signature>
      <ncom:dateSigned>2020-10-30</ncom:dateSigned>
      <ncom:nameOfApplicant>SPDR SERIES TRUST</ncom:nameOfApplicant>
      <ncom:signature>Daniel Foley</ncom:signature>
      <ncom:signerName>Daniel Foley</ncom:signerName>
      <ncom:title>Assistant Treasurer</ncom:title>
    </signature>
  </formData>
  <documents>XXXX</documents>
</edgarSubmission>
