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        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5202064.35000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Aerie Pharmaceuticals Inc</name>
        <lei>529900SFXHDHUO324R09</lei>
        <title>Aerie Pharmaceuticals Inc</title>
        <cusip>00771V108</cusip>
        <identifiers>
          <isin value="US00771V1089"/>
        </identifiers>
        <balance>255476.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3770825.76000000</valUSD>
        <pctVal>1.548960109396</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zoetis Inc</name>
        <lei>549300HD9Q1LOC9KLJ48</lei>
        <title>Zoetis Inc</title>
        <cusip>98978V103</cusip>
        <identifiers>
          <isin value="US98978V1035"/>
        </identifiers>
        <balance>77672.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10644170.88000000</valUSD>
        <pctVal>4.372356915988</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zogenix Inc</name>
        <lei>54930089H3HF4C32SK78</lei>
        <title>Zogenix Inc</title>
        <cusip>98978L204</cusip>
        <identifiers>
          <isin value="US98978L2043"/>
        </identifiers>
        <balance>194808.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5261764.08000000</valUSD>
        <pctVal>2.161399964812</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Supernus Pharmaceuticals Inc</name>
        <lei>549300GRM36VBKISYJ58</lei>
        <title>Supernus Pharmaceuticals Inc</title>
        <cusip>868459108</cusip>
        <identifiers>
          <isin value="US8684591089"/>
        </identifiers>
        <balance>152008.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3610190.00000000</valUSD>
        <pctVal>1.482974990958</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Pacira BioSciences Inc</name>
        <lei>N/A</lei>
        <title>Pacira BioSciences Inc</title>
        <cusip>695127100</cusip>
        <identifiers>
          <isin value="US6951271005"/>
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        <balance>159515.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8369752.05000000</valUSD>
        <pctVal>3.438083029058</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Merck &amp; Co Inc</name>
        <lei>4YV9Y5M8S0BRK1RP0397</lei>
        <title>Merck &amp; Co Inc</title>
        <cusip>58933Y105</cusip>
        <identifiers>
          <isin value="US58933Y1055"/>
        </identifiers>
        <balance>136481.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10554075.73000000</valUSD>
        <pctVal>4.335348100869</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Horizon Therapeutics Plc</name>
        <lei>N/A</lei>
        <title>Horizon Therapeutics Plc</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="IE00BQPVQZ61"/>
        </identifiers>
        <balance>226036.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12563080.88000000</valUSD>
        <pctVal>5.160596742674</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Collegium Pharmaceutical Inc</name>
        <lei>54930049FXZMTLW8D496</lei>
        <title>Collegium Pharmaceutical Inc</title>
        <cusip>19459J104</cusip>
        <identifiers>
          <isin value="US19459J1043"/>
        </identifiers>
        <balance>142295.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2490162.50000000</valUSD>
        <pctVal>1.022895944790</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2195034.10000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Mylan NV</name>
        <lei>549300A0CD4KNFGIIS89</lei>
        <title>Mylan NV</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="NL0011031208"/>
        </identifiers>
        <balance>653287.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10504854.96000000</valUSD>
        <pctVal>4.315129450065</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Provention Bio Inc</name>
        <lei>5493003LM26XAVJKLD34</lei>
        <title>Provention Bio Inc</title>
        <cusip>74374N102</cusip>
        <identifiers>
          <isin value="US74374N1028"/>
        </identifiers>
        <balance>105848.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1493515.28000000</valUSD>
        <pctVal>0.613498405583</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Johnson &amp; Johnson</name>
        <lei>549300G0CFPGEF6X2043</lei>
        <title>Johnson &amp; Johnson</title>
        <cusip>478160104</cusip>
        <identifiers>
          <isin value="US4781601046"/>
        </identifiers>
        <balance>73258.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10302272.54000000</valUSD>
        <pctVal>4.231913701733</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Revance Therapeutics Inc</name>
        <lei>549300N33TFDZHS81H11</lei>
        <title>Revance Therapeutics Inc</title>
        <cusip>761330109</cusip>
        <identifiers>
          <isin value="US7613301099"/>
        </identifiers>
        <balance>152358.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3720582.36000000</valUSD>
        <pctVal>1.528321387983</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1137752.22000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Nektar Therapeutics</name>
        <lei>5299005I24806IOIYE03</lei>
        <title>Nektar Therapeutics</title>
        <cusip>640268108</cusip>
        <identifiers>
          <isin value="US6402681083"/>
        </identifiers>
        <balance>350393.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8115101.88000000</valUSD>
        <pctVal>3.333479162349</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="921686.20000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Arvinas Inc</name>
        <lei>N/A</lei>
        <title>Arvinas Inc</title>
        <cusip>04335A105</cusip>
        <identifiers>
          <isin value="US04335A1051"/>
        </identifiers>
        <balance>169206.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5675169.24000000</valUSD>
        <pctVal>2.331216377082</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1339352.82000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cara Therapeutics Inc</name>
        <lei>549300COVOY41P0GZ881</lei>
        <title>Cara Therapeutics Inc</title>
        <cusip>140755109</cusip>
        <identifiers>
          <isin value="US1407551092"/>
        </identifiers>
        <balance>134822.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2305456.20000000</valUSD>
        <pctVal>0.947023255660</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1909186.56000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Intersect ENT Inc</name>
        <lei>549300SWZUVLSFMOXR50</lei>
        <title>Intersect ENT Inc</title>
        <cusip>46071F103</cusip>
        <identifiers>
          <isin value="US46071F1030"/>
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        <balance>157837.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2137112.98000000</valUSD>
        <pctVal>0.877872107061</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MyoKardia Inc</name>
        <lei>549300OLNNNZ1NI9UY54</lei>
        <title>MyoKardia Inc</title>
        <cusip>62857M105</cusip>
        <identifiers>
          <isin value="US62857M1053"/>
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        <balance>81546.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7878974.52000000</valUSD>
        <pctVal>3.236483998781</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Phathom Pharmaceuticals Inc</name>
        <lei>N/A</lei>
        <title>Phathom Pharmaceuticals Inc</title>
        <cusip>71722W107</cusip>
        <identifiers>
          <isin value="US71722W1071"/>
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        <balance>10910.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>359048.10000000</valUSD>
        <pctVal>0.147487903088</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Axsome Therapeutics Inc</name>
        <lei>549300EXGR0XLRJEIB95</lei>
        <title>Axsome Therapeutics Inc</title>
        <cusip>05464T104</cusip>
        <identifiers>
          <isin value="US05464T1043"/>
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        <balance>144090.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11855725.20000000</valUSD>
        <pctVal>4.870032871201</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="10343594.24000000"/>
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      </invstOrSec>
      <invstOrSec>
        <name>State Street Global Advisors</name>
        <lei>5493000HFJPORCLSV250</lei>
        <title>State Street Institutional Liquid Reserves Fund</title>
        <cusip>85749P101</cusip>
        <identifiers>
          <isin value="US85749P1012"/>
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        <balance>149811.44000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>149871.36000000</valUSD>
        <pctVal>0.061563374432</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Intra-Cellular Therapies Inc</name>
        <lei>5299002U2KGF193IJA20</lei>
        <title>Intra-Cellular Therapies Inc</title>
        <cusip>46116X101</cusip>
        <identifiers>
          <isin value="US46116X1019"/>
        </identifiers>
        <balance>192227.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4934467.09000000</valUSD>
        <pctVal>2.026954616842</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1581304.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Tricida Inc</name>
        <lei>549300QVPFFJC8SZXG25</lei>
        <title>Tricida Inc</title>
        <cusip>89610F101</cusip>
        <identifiers>
          <isin value="US89610F1012"/>
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        <balance>72429.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1990348.92000000</valUSD>
        <pctVal>0.817585133093</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="41220.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Elanco Animal Health Inc</name>
        <lei>549300SHPNDCE059M934</lei>
        <title>Elanco Animal Health Inc</title>
        <cusip>28414H103</cusip>
        <identifiers>
          <isin value="US28414H1032"/>
        </identifiers>
        <balance>471844.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10121053.80000000</valUSD>
        <pctVal>4.157473614283</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>

    </explntrNotes>
    <signature>
      <ncom:dateSigned>2020-07-29</ncom:dateSigned>
      <ncom:nameOfApplicant>SPDR SERIES TRUST</ncom:nameOfApplicant>
      <ncom:signature>Daniel Foley</ncom:signature>
      <ncom:signerName>Daniel Foley</ncom:signerName>
      <ncom:title>Assistant Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
