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      <invstOrSec>
        <name>Biohaven Pharmaceutical Holding Co Ltd</name>
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        <name>Veracyte Inc</name>
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        <name>Anika Therapeutics Inc</name>
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        <name>Amicus Therapeutics Inc</name>
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        <name>ChemoCentryx Inc</name>
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        <name>OPKO Health Inc</name>
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        <name>Vericel Corp</name>
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        <name>Voyager Therapeutics Inc</name>
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        <name>Gossamer Bio Inc</name>
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        <name>BioMarin Pharmaceutical Inc</name>
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        <name>ZIOPHARM Oncology Inc</name>
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          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="15825722.84000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Regeneron Pharmaceuticals Inc</name>
        <lei>549300RCBFWIRX3HYQ56</lei>
        <title>Regeneron Pharmaceuticals Inc</title>
        <cusip>75886F107</cusip>
        <identifiers>
          <isin value="US75886F1075"/>
        </identifiers>
        <balance>201615.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>98446588.35000000</valUSD>
        <pctVal>2.770685669133</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alkermes PLC</name>
        <lei>N/A</lei>
        <title>Alkermes PLC</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="IE00B56GVS15"/>
        </identifiers>
        <balance>2780757.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>40098515.94000000</valUSD>
        <pctVal>1.128534622992</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Agenus Inc</name>
        <lei>529900NDQQGU5H4UJK81</lei>
        <title>Agenus Inc</title>
        <cusip>00847G705</cusip>
        <identifiers>
          <isin value="US00847G7051"/>
        </identifiers>
        <balance>1477366.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3619546.70000000</valUSD>
        <pctVal>0.101868701988</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="93835.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Catalyst Pharmaceuticals Inc</name>
        <lei>5299004O0R5XXLA5H544</lei>
        <title>Catalyst Pharmaceuticals Inc</title>
        <cusip>14888U101</cusip>
        <identifiers>
          <isin value="US14888U1016"/>
        </identifiers>
        <balance>5587140.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>21510489.00000000</valUSD>
        <pctVal>0.605392270136</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5455043.67000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Kura Oncology Inc</name>
        <lei>5493005QORQTZCZYOP39</lei>
        <title>Kura Oncology Inc</title>
        <cusip>50127T109</cusip>
        <identifiers>
          <isin value="US50127T1097"/>
        </identifiers>
        <balance>416130.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4140493.50000000</valUSD>
        <pctVal>0.116530254586</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alector Inc</name>
        <lei>549300Z8RQOIY1JMHC25</lei>
        <title>Alector Inc</title>
        <cusip>014442107</cusip>
        <identifiers>
          <isin value="US0144421072"/>
        </identifiers>
        <balance>509956.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12305238.28000000</valUSD>
        <pctVal>0.346319236949</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="8139421.64000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AMAG Pharmaceuticals Inc</name>
        <lei>549300HCK1560YVVY867</lei>
        <title>AMAG Pharmaceuticals Inc</title>
        <cusip>00163U106</cusip>
        <identifiers>
          <isin value="US00163U1060"/>
        </identifiers>
        <balance>1480835.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9151560.30000000</valUSD>
        <pctVal>0.257561967340</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1303520.70000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Xencor Inc</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>Xencor Inc</title>
        <cusip>98401F105</cusip>
        <identifiers>
          <isin value="US98401F1057"/>
        </identifiers>
        <balance>572497.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17106210.36000000</valUSD>
        <pctVal>0.481438033475</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="8433572.16000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MacroGenics Inc</name>
        <lei>5493001KJQUA83L8MH79</lei>
        <title>MacroGenics Inc</title>
        <cusip>556099109</cusip>
        <identifiers>
          <isin value="US5560991094"/>
        </identifiers>
        <balance>964630.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5614146.60000000</valUSD>
        <pctVal>0.158004820580</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Rocket Pharmaceuticals Inc</name>
        <lei>549300R7VV82YUIN4Y93</lei>
        <title>Rocket Pharmaceuticals Inc</title>
        <cusip>77313F106</cusip>
        <identifiers>
          <isin value="US77313F1066"/>
        </identifiers>
        <balance>304781.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4251694.95000000</valUSD>
        <pctVal>0.119659913714</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2954406.43000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Akebia Therapeutics Inc</name>
        <lei>549300CBQEHMKEEGNX42</lei>
        <title>Akebia Therapeutics Inc</title>
        <cusip>00972D105</cusip>
        <identifiers>
          <isin value="US00972D1054"/>
        </identifiers>
        <balance>1103037.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8361020.46000000</valUSD>
        <pctVal>0.235312974843</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NextCure Inc</name>
        <lei>549300Y5PR6RJR1STI24</lei>
        <title>NextCure Inc</title>
        <cusip>65343E108</cusip>
        <identifiers>
          <isin value="US65343E1082"/>
        </identifiers>
        <balance>195025.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7229576.75000000</valUSD>
        <pctVal>0.203469566907</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Krystal Biotech Inc</name>
        <lei>549300YONUY68210OE41</lei>
        <title>Krystal Biotech Inc</title>
        <cusip>501147102</cusip>
        <identifiers>
          <isin value="US5011471027"/>
        </identifiers>
        <balance>241799.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10455388.76000000</valUSD>
        <pctVal>0.294256980237</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="6923346.40000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Momenta Pharmaceuticals Inc</name>
        <lei>529900BB2VMRCT4YQ588</lei>
        <title>Momenta Pharmaceuticals Inc</title>
        <cusip>60877T100</cusip>
        <identifiers>
          <isin value="US60877T1007"/>
        </identifiers>
        <balance>837850.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>22789520.00000000</valUSD>
        <pctVal>0.641389382087</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>

    </explntrNotes>
    <signature>
      <ncom:dateSigned>2020-04-30</ncom:dateSigned>
      <ncom:nameOfApplicant>SPDR SERIES TRUST</ncom:nameOfApplicant>
      <ncom:signature>Daniel Foley</ncom:signature>
      <ncom:signerName>Daniel Foley</ncom:signerName>
      <ncom:title>Assistant Treasurer</ncom:title>
    </signature>
  </formData>
  <documents>XXXX</documents>
</edgarSubmission>
