NPORT-P false 0001064642 XXXXXXXX S000010018 C000027706 SPDR SERIES TRUST 811-08839 0001064642 5493004JVD6CQEEJSS37 One Iron Street Boston 02210 617-664-8594 SPDR(R) S&P(R) Biotech ETF S000010018 549300Y3ODFMPD5XXL58 2020-06-30 2019-12-31 N 4745371893.89 417411385.1 4327960508.79 0 0 0 0 0 0 0 0 0 0 0 0 0 0 UST Rocket Pharmaceuticals Inc 549300R7VV82YUIN4Y93 77313F106 291914.00000000 NS USD 6643962.64000000 0.153512552309 Long EC CORP US N 1 N N Principia Biopharma Inc 549300WHPKRLU16IRE69 74257L108 246976.00000000 NS USD 13529345.28000000 0.312603251636 Long EC CORP US N 1 N N N Emergent BioSolutions Inc 549300YW6TUOX8BE5103 29089Q105 732318.00000000 NS USD 39508556.10000000 0.912867758838 Long EC CORP US N 1 N N N Intellia Therapeutics Inc 5493002T5BCPE5DZC723 45826J105 841239.00000000 NS USD 12340976.13000000 0.285145303542 Long EC CORP US N 1 N N Intrexon Corp 549300XCWNQU35K64G19 46122T102 2127139.00000000 NS USD 11656721.72000000 0.269335214504 Long EC CORP US N 1 N N Moderna Inc 549300EI6OKH5K5Q2G38 60770K107 3009634.00000000 NS USD 58868441.04000000 1.360188960145 Long EC CORP US N 1 N N Coherus Biosciences Inc 5493007IL8W5MV932D26 19249H103 2180456.00000000 NS USD 39259110.28000000 0.907104170665 Long EC CORP US N 1 N N Invitae Corp 549300MYI59DZW1WIX92 46185L103 4205314.00000000 NS USD 67831714.82000000 1.567290521302 Long EC CORP US N 1 N N Progenics Pharmaceuticals Inc 5299005B0KKBVJ0B2156 743187106 1842032.00000000 NS USD 9375942.88000000 0.216636516459 Long EC CORP US N 1 N N N State Street Global Advisors 5493008BJIBKQ5KTIF74 857492706 368737516.25000000 NS USD 368737516.25000000 8.519890962523 Long STIV RF US N 1 N N Cytokinetics Inc 549300BE5DY1HW7IHA64 23282W605 887530.00000000 NS USD 9416693.30000000 0.217578078193 Long EC CORP US N 1 N N Intercept Pharmaceuticals Inc N/A 45845P108 607734.00000000 NS USD 75310397.28000000 1.740089751906 Long EC CORP US N 1 N N Dynavax Technologies Corp 549300T5URIXWDILX594 268158201 1655298.00000000 NS USD 9468304.56000000 0.218770585839 Long EC CORP US N 1 N N BioMarin Pharmaceutical Inc NSLL8ITTRR0J5HEMR848 09061G101 904971.00000000 NS USD 76515298.05000000 1.767929672523 Long EC CORP US N 1 N N N Vertex Pharmaceuticals Inc 54930015RAQRRZ5ZGJ91 92532F100 331333.00000000 NS USD 72545360.35000000 1.676201994049 Long EC CORP US N 1 N N N Global Blood Therapeutics Inc 549300U4G0QKK99GRT15 37890U108 943665.00000000 NS USD 75011930.85000000 1.733193514535 Long EC CORP US N 1 N N Akcea Therapeutics Inc 5299005MBXDP2HBTJY60 00972L107 394994.00000000 NS USD 6691198.36000000 0.154603960604 Long EC CORP US N 1 N N Voyager Therapeutics Inc 54930082S4XVR0ZWCC74 92915B106 811451.00000000 NS USD 11319741.45000000 0.261549092858 Long EC CORP US N 1 N N Madrigal Pharmaceuticals Inc 549300CHIMT2EUSNJB60 558868105 289968.00000000 NS USD 26418984.48000000 0.610425728847 Long EC CORP US N 1 N N AnaptysBio Inc 529900HH4WQT03IG1A12 032724106 1411066.00000000 NS USD 22929822.50000000 0.529806648037 Long EC CORP US N 1 N N Acceleron Pharma Inc 529900TQRID2UY164805 00434H108 512041.00000000 NS USD 27148413.82000000 0.627279610450 Long EC CORP US N 1 N N Adverum Biotechnologies Inc 529900ZEDOOZL1EWHJ89 00773U108 1984164.00000000 NS USD 22857569.28000000 0.528137196112 Long EC CORP US N 1 N N Rhythm Pharmaceuticals Inc 529900JPNWXQ8DPLA551 76243J105 385479.00000000 NS USD 8850597.84000000 0.204498119195 Long EC CORP US N 1 N N Bluebird Bio Inc N/A 09609G100 808320.00000000 NS USD 70930080.00000000 1.638880018797 Long EC CORP US N 1 N N Dicerna Pharmaceuticals Inc 549300CTZMJMPH28WN39 253031108 542956.00000000 NS USD 11961320.68000000 0.276373147483 Long EC CORP US N 1 N N N Alkermes PLC N/A 000000000 2663239.00000000 NS USD 54330075.60000000 1.255327434010 Long EC CORP IE N 1 N N N Gossamer Bio Inc 549300ZOC0N2W6PSFR58 38341P102 789860.00000000 NS USD 12345511.80000000 0.285250102789 Long EC CORP US N 1 N N Athenex Inc 5493001V4L0Q5EPPOH52 04685N103 1113553.00000000 NS USD 17003954.31000000 0.392886078222 Long EC CORP US N 1 N N TG Therapeutics Inc 529900X21UKABN9NJ529 88322Q108 1684027.00000000 NS USD 18692699.70000000 0.431905505192 Long EC CORP US N 1 N N Radius Health Inc 549300EV6I2M6E0YVT27 750469207 1318323.00000000 NS USD 26577391.68000000 0.614085817696 Long EC CORP US N 1 N N Kodiak Sciences Inc N/A 50015M109 184832.00000000 NS USD 13298662.40000000 0.307273191910 Long EC CORP US N 1 N N Avrobio Inc N/A 05455M100 236643.00000000 NS USD 4763623.59000000 0.110066244373 Long EC CORP US N 1 N N Biogen Inc W8J5WZB5IY3K0NDQT671 09062X103 244388.00000000 NS USD 72517251.24000000 1.675552517004 Long EC CORP US N 1 N N N Agios Pharmaceuticals Inc 529900ONJHY8EOGYT555 00847X104 1099540.00000000 NS USD 52503035.00000000 1.213112617210 Long EC CORP US N 1 N N Agenus Inc 529900NDQQGU5H4UJK81 00847G705 1414886.00000000 NS USD 5758586.02000000 0.133055419713 Long EC CORP US N 1 N N CareDx Inc 549300NQOFKL9NON0U06 14167L103 1663126.00000000 NS USD 35873627.82000000 0.828880664394 Long EC CORP US N 1 N N AMAG Pharmaceuticals Inc 549300HCK1560YVVY867 00163U106 1418285.00000000 NS USD 17260528.45000000 0.398814370300 Long EC CORP US N 1 N N Sangamo Therapeutics Inc 2549006WMRKRC4G32Z67 800677106 2408787.00000000 NS USD 20161547.19000000 0.465844065560 Long EC CORP US N 1 N N Catalyst Pharmaceuticals Inc 5299004O0R5XXLA5H544 14888U101 5351002.00000000 NS USD 20066257.50000000 0.463642342836 Long EC CORP US N 1 N N Incyte Corp 549300Z4WN6JVZ3T4680 45337C102 792842.00000000 NS USD 69230963.44000000 1.599620960020 Long EC CORP US N 1 N N N ArQule Inc 529900E3KUAEG4GJ1707 04269E107 1856603.00000000 NS USD 37057795.88000000 0.856241543903 Long EC CORP US N 1 N N N Amgen Inc 62QBXGPJ34PQ72Z12S66 031162100 306454.00000000 NS USD 73876865.78000000 1.706967187661 Long EC CORP US N 1 N N N Alector Inc 549300Z8RQOIY1JMHC25 014442107 488304.00000000 NS USD 8413477.92000000 0.194398213729 Long EC CORP US N 1 N N AbbVie Inc FR5LCKFTG8054YNNRU85 00287Y109 825956.00000000 NS USD 73130144.24000000 1.689713759898 Long EC CORP US N 1 N N N Alnylam Pharmaceuticals Inc 529900S3ZI14OWRJII50 02043Q107 616219.00000000 NS USD 70969942.23000000 1.639801058393 Long EC CORP US N 1 N N N Medicines Co/The 254900Z72DIL282LFL79 584688105 893677.00000000 NS USD 75908924.38000000 1.753919062473 Long EC CORP US N 1 N N Regeneron Pharmaceuticals Inc 549300RCBFWIRX3HYQ56 75886F107 192696.00000000 NS USD 72353494.08000000 1.671768814272 Long EC CORP US N 1 N N N Blueprint Medicines Corp 5299004CC60O9T5HVM83 09627Y109 841884.00000000 NS USD 67443327.24000000 1.558316604391 Long EC CORP US N 1 N N N Anika Therapeutics Inc 529900R9LS3Z0O6QH455 035255108 346118.00000000 NS USD 17946218.30000000 0.414657626000 Long EC CORP US N 1 N N N Prothena Corp PLC 5299009ZXQ8NIIJ8OL30 000000000 230886.00000000 NS USD 3654925.38000000 0.084449138862 Long EC CORP IE N 1 N N N ACADIA Pharmaceuticals Inc 529900O3044NO0PEA039 004225108 1636305.00000000 NS USD 70001127.90000000 1.617416049842 Long EC CORP US N 1 N N ImmunoGen Inc 54930084U0R1OP766Y02 45253H101 2298927.00000000 NS USD 11736022.34000000 0.271167500631 Long EC CORP US N 1 N N Portola Pharmaceuticals Inc 549300BM3O4O0CNBGJ64 737010108 1635240.00000000 NS USD 39049531.20000000 0.902261726295 Long EC CORP US N 1 N N Epizyme Inc 549300TNFWF88O4U4605 29428V104 870146.00000000 NS USD 21405591.60000000 0.494588422341 Long EC CORP US N 1 N N Ionis Pharmaceuticals Inc 549300SI4ZGLG0BLUZ92 462222100 1150700.00000000 NS USD 69513787.00000000 1.606155759943 Long EC CORP US N 1 N N N Apellis Pharmaceuticals Inc 254900HS0ZFRXXSB9D42 03753U106 1299258.00000000 NS USD 39783279.96000000 0.919215410565 Long EC CORP US N 1 N N N Karuna Therapeutics Inc N/A 48576A100 41568.00000000 NS USD 3131733.12000000 0.072360482810 Long EC CORP US N 1 N N Arena Pharmaceuticals Inc 529900CVGQMPJ3A3NI85 040047607 794573.00000000 NS USD 36089505.66000000 0.833868645212 Long EC CORP US N 1 N N N G1 Therapeutics Inc 529900TC35UPZQYRKW13 3621LQ109 696221.00000000 NS USD 18401121.03000000 0.425168413450 Long EC CORP US N 1 N N Iovance Biotherapeutics Inc 549300220Z2GHH33XL82 462260100 1904679.00000000 NS USD 52721514.72000000 1.218160715952 Long EC CORP US N 1 N N N Homology Medicines Inc 549300RWKPJEFTM3K452 438083107 322741.00000000 NS USD 6680738.70000000 0.154362284185 Long EC CORP US N 1 N N Viking Therapeutics Inc 529900IVC72YPFA25M37 92686J106 2251466.00000000 NS USD 18056757.32000000 0.417211693205 Long EC CORP US N 1 N N FibroGen Inc 549300Q914ULWWY95822 31572Q808 999944.00000000 NS USD 42887598.16000000 0.990942455988 Long EC CORP US N 1 N N N Momenta Pharmaceuticals Inc 529900BB2VMRCT4YQ588 60877T100 802502.00000000 NS USD 15833364.46000000 0.365838931012 Long EC CORP US N 1 N N N United Therapeutics Corp 5299005C4HZL4UWROC14 91307C102 809490.00000000 NS USD 71299879.20000000 1.647424440569 Long EC CORP US N 1 N N N Ironwood Pharmaceuticals Inc 549300PC8MR6QHH6P296 46333X108 2523747.00000000 NS USD 33591072.57000000 0.776140921382 Long EC CORP US N 1 N N PTC Therapeutics Inc 549300UJLWOIWFDGB318 69366J200 1103226.00000000 NS USD 52987944.78000000 1.224316734692 Long EC CORP US N 1 N N N Y-mAbs Therapeutics Inc N/A 984241109 313668.00000000 NS USD 9802125.00000000 0.226483697808 Long EC CORP US N 1 N N N Stemline Therapeutics Inc 529900EFNCIRC8Q7V234 85858C107 1258802.00000000 NS USD 13381065.26000000 0.309177157065 Long EC CORP US N 1 N N Atara Biotherapeutics Inc 549300WBXUXZRE03MS38 046513107 1168613.00000000 NS USD 19247056.11000000 0.444714226733 Long EC CORP US N 1 N N Turning Point Therapeutics Inc N/A 90041T108 506562.00000000 NS USD 31553746.98000000 0.729067349757 Long EC CORP US N 1 N N N Retrophin Inc N/A 761299106 858504.00000000 NS USD 12190756.80000000 0.281674400106 Long EC CORP US N 1 N N Gilead Sciences Inc 549300WTZWR07K8MNV44 375558103 1103082.00000000 NS USD 71678268.36000000 1.656167338274 Long EC CORP US N 1 N N N Xencor Inc 549300V5IF65437JKG30 98401F105 548281.00000000 NS USD 18855383.59000000 0.435664409407 Long EC CORP US N 1 N N Exact Sciences Corp 549300VM3X1FYD4N9Z14 30063P105 831992.00000000 NS USD 76942620.16000000 1.777803193992 Long EC CORP US N 1 N N Neurocrine Biosciences Inc 549300FECER0XBN49756 64125C109 656079.00000000 NS USD 70521931.71000000 1.629449519393 Long EC CORP US N 1 N N N Flexion Therapeutics Inc 549300X8HYW1HZKCDG90 33938J106 948340.00000000 NS USD 19630638.00000000 0.453577105431 Long EC CORP US N 1 N N Mirati Therapeutics Inc 529900GYRW59IDQV6N54 60468T105 646356.00000000 NS USD 83289434.16000000 1.924449957222 Long EC CORP US N 1 N N Editas Medicine Inc 5299000AON4Q9NT2JE42 28106W103 911034.00000000 NS USD 26975716.74000000 0.623289345760 Long EC CORP US N 1 N N Natera Inc N/A 632307104 1211592.00000000 NS USD 40818534.48000000 0.943135557662 Long EC CORP US N 1 N N N NextCure Inc 549300Y5PR6RJR1STI24 65343E108 186748.00000000 NS USD 10519514.84000000 0.243059399886 Long EC CORP US N 1 N N N REGENXBIO Inc 549300EOES47LATSET33 75901B107 920949.00000000 NS USD 37731280.53000000 0.871802791485 Long EC CORP US N 1 N N N Puma Biotechnology Inc N/A 74587V107 2820129.00000000 NS USD 24676128.75000000 0.570156051560 Long EC CORP US N 1 N N Bridgebio Pharma Inc 54930028YG89VTY2J114 10806X102 355936.00000000 NS USD 12475556.80000000 0.288254866805 Long EC CORP US N 1 N N N Arrowhead Pharmaceuticals Inc 549300O3CSB8T7OZ3D66 04280A100 1091624.00000000 NS USD 69241710.32000000 1.599869272821 Long EC CORP US N 1 N N Aimmune Therapeutics Inc 549300WDF7T2EVBC1877 00900T107 1268174.00000000 NS USD 42445783.78000000 0.980734082341 Long EC CORP US N 1 N N Clovis Oncology Inc 529900WCUY9ZAHMRV489 189464100 2646534.00000000 NS USD 27590116.95000000 0.637485413602 Long EC CORP US N 1 N N Ligand Pharmaceuticals Inc 5493008K7TB0IKP37H79 53220K504 684161.00000000 NS USD 71351150.69000000 1.648609097635 Long EC CORP US N 1 N N Akebia Therapeutics Inc 549300CBQEHMKEEGNX42 00972D105 1056483.00000000 NS USD 6676972.56000000 0.154275265368 Long EC CORP US N 1 N N Heron Therapeutics Inc 549300DR2I1DOPD2IX53 427746102 1640043.00000000 NS USD 38541010.50000000 0.890512065018 Long EC CORP US N 1 N N Deciphera Pharmaceuticals Inc 529900QR4WAPYY0CBF25 24344T101 617920.00000000 NS USD 38459340.80000000 0.888625039944 Long EC CORP US N 1 N N N MacroGenics Inc 5493001KJQUA83L8MH79 556099109 923863.00000000 NS USD 10051629.44000000 0.232248640429 Long EC CORP US N 1 N N N Sage Therapeutics Inc 5493000JX4BJS9W6CN35 78667J108 995590.00000000 NS USD 71871642.10000000 1.660635349006 Long EC CORP US N 1 N N State Street Global Advisors 5493000HFJPORCLSV250 85749P101 2410901.88000000 NS USD 2411142.97000000 0.055710835741 Long STIV RF US N 1 N N N Ultragenyx Pharmaceutical Inc 529900EV44GVDN1DCX77 90400D108 1052675.00000000 NS USD 44959749.25000000 1.038820690685 Long EC CORP US N 1 N N Myriad Genetics Inc 52990044IHUOUMETT163 62855J104 1585975.00000000 NS USD 43186099.25000000 0.997839494198 Long EC CORP US N 1 N N N Immunomedics Inc 5493007ZU7DDO8PSIM59 452907108 3133993.00000000 NS USD 66315291.88000000 1.532252702983 Long EC CORP US N 1 N N Veracyte Inc 529900ESWZRHXOW27Z37 92337F107 1007446.00000000 NS USD 28127892.32000000 0.649911020742 Long EC CORP US N 1 N N Sarepta Therapeutics Inc 549300IKDPIED8J8IG21 803607100 549446.00000000 NS USD 70900511.84000000 1.638196829569 Long EC CORP US N 1 N N ChemoCentryx Inc 529900YTTXUSFQTAKY40 16383L106 216304.00000000 NS USD 8554823.20000000 0.197664077170 Long EC CORP US N 1 N N N Insmed Inc 529900Q55QAG41CCAC11 457669307 1591994.00000000 NS USD 38016816.72000000 0.878400268273 Long EC CORP US N 1 N N Biohaven Pharmaceutical Holding Co Ltd 5299007STZTNN32O9920 000000000 1073398.00000000 NS USD 58435787.12000000 1.350192244160 Long EC CORP VG N 1 N N N Spectrum Pharmaceuticals Inc 549300COU30WSP3O5I07 84763A108 1556453.00000000 NS USD 5665488.92000000 0.130904358034 Long EC CORP US N 1 N N N ZIOPHARM Oncology Inc N/A 98973P101 2533037.00000000 NS USD 11955934.64000000 0.276248699952 Long EC CORP US N 1 N N Exelixis Inc N/A 30161Q104 4071360.00000000 NS USD 71737363.20000000 1.657532758311 Long EC CORP US N 1 N N N Twist Bioscience Corp 549300T23BL59LCOH584 90184D100 430075.00000000 NS USD 9031575.00000000 0.208679699864 Long EC CORP US N 1 N N Audentes Therapeutics Inc 549300PZYT0QC9UNJF13 05070R104 401020.00000000 NS USD 23997036.80000000 0.554465244108 Long EC CORP US N 1 N N N Vericel Corp 54930076YM3PLTDR4B91 92346J108 815719.00000000 NS USD 14193510.60000000 0.327949170773 Long EC CORP US N 1 N N Achillion Pharmaceuticals Inc 529900LZPJ796VSWZM38 00448Q201 2226706.00000000 NS USD 13427037.18000000 0.310239364539 Long EC CORP US N 1 N N N Enanta Pharmaceuticals Inc 529900SSN4DODDQSN594 29251M106 341571.00000000 NS USD 21102256.38000000 0.487579688796 Long EC CORP US N 1 N N N Esperion Therapeutics Inc 549300OFU56UKEWVUS92 29664W105 579896.00000000 NS USD 34579198.48000000 0.798972135022 Long EC CORP US N 1 N N Kura Oncology Inc 5493005QORQTZCZYOP39 50127T109 398562.00000000 NS USD 5480227.50000000 0.126623787090 Long EC CORP US N 1 N N N BioCryst Pharmaceuticals Inc 549300Z0INP1Z5NP6J59 09058V103 2701562.00000000 NS USD 9320388.90000000 0.215352910015 Long EC CORP US N 1 N N Krystal Biotech Inc 549300YONUY68210OE41 501147102 231615.00000000 NS USD 12826838.70000000 0.296371435782 Long EC CORP US N 1 N N Eagle Pharmaceuticals Inc/DE 549300TN20OLYTJVP152 269796108 298567.00000000 NS USD 17937905.36000000 0.414465550773 Long EC CORP US N 1 N N Karyopharm Therapeutics Inc 549300J1VANRCNTYST87 48576U106 1953943.00000000 NS USD 37457087.31000000 0.865467400497 Long EC CORP US N 1 N N Ra Pharmaceuticals Inc 549300JE4B54MQ4MWX95 74933V108 906043.00000000 NS USD 42520597.99000000 0.982462707403 Long EC CORP US N 1 N N N Amicus Therapeutics Inc 549300MRD1SMUTNBPQ53 03152W109 5609401.00000000 NS USD 54635565.74000000 1.262385958213 Long EC CORP US N 1 N N N Halozyme Therapeutics Inc 529900242I3SV9AGM753 40637H109 1507976.00000000 NS USD 26736414.48000000 0.617760130336 Long EC CORP US N 1 N N N OPKO Health Inc 529900A4S2D4OGOJLL02 68375N103 9549106.00000000 NS USD 14037185.82000000 0.324337197427 Long EC CORP US N 1 N N Seattle Genetics Inc N/A 812578102 637147.00000000 NS USD 72800416.22000000 1.682095205631 Long EC CORP US N 1 N N N Kadmon Holdings Inc 549300BBVICD23L50606 48283N106 851604.00000000 NS USD 3857766.12000000 0.089135890037 Long EC CORP US N 1 N N N Alexion Pharmaceuticals Inc M1YXUUZR0EIMU8T0EM75 015351109 657051.00000000 NS USD 71060065.65000000 1.641883411497 Long EC CORP US N 1 N N N Fate Therapeutics Inc 549300L14Q4UHOODLA90 31189P102 1109911.00000000 NS USD 21720958.27000000 0.501875149412 Long EC CORP US N 1 N N N Denali Therapeutics Inc 549300ZTQ2HO18L3Q830 24823R105 530610.00000000 NS USD 9243226.20000000 0.213570021751 Long EC CORP US N 1 N N Vanda Pharmaceuticals Inc 529900AY8VOOQBKJ0O70 921659108 977463.00000000 NS USD 16040167.83000000 0.370617241017 Long EC CORP US N 1 N N N Allogene Therapeutics Inc N/A 019770106 899007.00000000 NS USD 23356201.86000000 0.539658386728 Long EC CORP US N 1 N N Allakos Inc 549300S6ZD1W6BPMDY37 01671P100 385332.00000000 NS USD 36745259.52000000 0.849020212762 Long EC CORP US N 1 N N 2020-01-31 SPDR SERIES TRUST Sujata Upreti Sujata Upreti Assistant Treasurer