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        <name>Prothena Corp PLC</name>
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        <name>State Street Global Advisors</name>
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        <name>Ionis Pharmaceuticals Inc</name>
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        <name>Dicerna Pharmaceuticals Inc</name>
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        <name>Halozyme Therapeutics Inc</name>
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        <name>Eagle Pharmaceuticals Inc/DE</name>
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        <name>Retrophin Inc</name>
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        <name>Exact Sciences Corp</name>
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        <name>OPKO Health Inc</name>
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        <name>Immunomedics Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Deciphera Pharmaceuticals Inc</name>
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      <invstOrSec>
        <name>Alkermes PLC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>State Street Global Advisors</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Ultragenyx Pharmaceutical Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Cytokinetics Inc</name>
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          <isCashCollateral>N</isCashCollateral>
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        <name>Agios Pharmaceuticals Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Editas Medicine Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>G1 Therapeutics Inc</name>
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        <name>Blueprint Medicines Corp</name>
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        <name>Xencor Inc</name>
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        <name>AnaptysBio Inc</name>
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        <name>Allakos Inc</name>
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        <name>Karyopharm Therapeutics Inc</name>
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        <name>Sage Therapeutics Inc</name>
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        <name>Arena Pharmaceuticals Inc</name>
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        <name>Vericel Corp</name>
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        <name>Fate Therapeutics Inc</name>
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        <name>Amgen Inc</name>
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        <name>Kura Oncology Inc</name>
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        <name>Celgene Corp</name>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="53971575.84000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Avrobio Inc</name>
        <lei>N/A</lei>
        <title>Avrobio Inc</title>
        <cusip>05455M100</cusip>
        <identifiers>
          <isin value="US05455M1009"/>
        </identifiers>
        <balance>293447.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4143471.64000000</valUSD>
        <pctVal>0.112850662314</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sarepta Therapeutics Inc</name>
        <lei>549300IKDPIED8J8IG21</lei>
        <title>Sarepta Therapeutics Inc</title>
        <cusip>803607100</cusip>
        <identifiers>
          <isin value="US8036071004"/>
        </identifiers>
        <balance>736227.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>55452617.64000000</valUSD>
        <pctVal>1.510295030700</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="23329013.12000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AMAG Pharmaceuticals Inc</name>
        <lei>549300HCK1560YVVY867</lei>
        <title>AMAG Pharmaceuticals Inc</title>
        <cusip>00163U106</cusip>
        <identifiers>
          <isin value="US00163U1060"/>
        </identifiers>
        <balance>1264606.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14606199.30000000</valUSD>
        <pctVal>0.397811161294</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="13279839.10000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Twist Bioscience Corp</name>
        <lei>549300T23BL59LCOH584</lei>
        <title>Twist Bioscience Corp</title>
        <cusip>90184D100</cusip>
        <identifiers>
          <isin value="US90184D1000"/>
        </identifiers>
        <balance>439661.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10499104.68000000</valUSD>
        <pctVal>0.285951255321</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Portola Pharmaceuticals Inc</name>
        <lei>549300BM3O4O0CNBGJ64</lei>
        <title>Portola Pharmaceuticals Inc</title>
        <cusip>737010108</cusip>
        <identifiers>
          <isin value="US7370101088"/>
        </identifiers>
        <balance>1644424.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>44103451.68000000</valUSD>
        <pctVal>1.201191697414</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="38526507.47000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ArQule Inc</name>
        <lei>529900E3KUAEG4GJ1707</lei>
        <title>ArQule Inc</title>
        <cusip>04269E107</cusip>
        <identifiers>
          <isin value="US04269E1073"/>
        </identifiers>
        <balance>3947467.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>28303338.39000000</valUSD>
        <pctVal>0.770863363027</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="7659481.23000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ACADIA Pharmaceuticals Inc</name>
        <lei>529900O3044NO0PEA039</lei>
        <title>ACADIA Pharmaceuticals Inc</title>
        <cusip>004225108</cusip>
        <identifiers>
          <isin value="US0042251084"/>
        </identifiers>
        <balance>1207435.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43455585.65000000</valUSD>
        <pctVal>1.183546563833</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="38969072.04000000"/>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>

    </explntrNotes>
    <signature>
      <ncom:dateSigned>2019-10-30</ncom:dateSigned>
      <ncom:nameOfApplicant>SPDR SERIES TRUST</ncom:nameOfApplicant>
      <ncom:signature>Sujata Upreti</ncom:signature>
      <ncom:signerName>Sujata Upreti</ncom:signerName>
      <ncom:title>Assistant Treasurer</ncom:title>
    </signature>
  </formData>
  <documents>XXXX</documents>
</edgarSubmission>
