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      <invstOrSec>
        <name>Celldex Therapeutics Inc</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>CG oncology Inc</name>
        <lei>N/A</lei>
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      <invstOrSec>
        <name>Cogent Biosciences Inc</name>
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      <invstOrSec>
        <name>Compass Therapeutics Inc</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Corvus Pharmaceuticals Inc</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Cullinan Therapeutics Inc</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Cytokinetics Inc</name>
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      <invstOrSec>
        <name>CytomX Therapeutics Inc</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Denali Therapeutics Inc</name>
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        <name>Dianthus Therapeutics Inc</name>
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      <invstOrSec>
        <name>Disc Medicine Inc</name>
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      <invstOrSec>
        <name>Dyne Therapeutics Inc</name>
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        <name>Emergent BioSolutions Inc</name>
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        <name>Erasca Inc</name>
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        <name>Exelixis Inc</name>
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        <name>First Tracks Biotherapeutics Inc</name>
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        <name>4D Molecular Therapeutics Inc</name>
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        <name>Damora Therapeutics Inc</name>
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        <name>Geron Corp</name>
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        <name>Gilead Sciences Inc</name>
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        <name>GRAIL Inc</name>
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        <name>Halozyme Therapeutics Inc</name>
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        <name>Hyperliquid Strategies Inc</name>
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      <invstOrSec>
        <name>Immix Biopharma Inc</name>
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        <name>Immunovant Inc</name>
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        <name>Incyte Corp</name>
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      <invstOrSec>
        <name>Inhibrx Biosciences Inc</name>
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        <name>Insmed Inc</name>
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        <name>CONTRA INHIBRX INC</name>
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        <name>Intellia Therapeutics Inc</name>
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        <name>Ionis Pharmaceuticals Inc</name>
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        <name>Iovance Biotherapeutics Inc</name>
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        <name>Ironwood Pharmaceuticals Inc</name>
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        <name>Perspective Therapeutics Inc</name>
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        <name>Kodiak Sciences Inc</name>
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        <name>MannKind Corp</name>
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        <name>CONTRA METSERA INC</name>
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        <name>Mineralys Therapeutics Inc</name>
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        <name>Moderna Inc</name>
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        <name>Monte Rosa Therapeutics Inc</name>
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        <name>Natera Inc</name>
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        <name>Neurocrine Biosciences Inc</name>
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        <name>Olema Pharmaceuticals Inc</name>
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        <name>REGENXBIO Inc</name>
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        <name>Replimune Group Inc</name>
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        <name>Revolution Medicines Inc</name>
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        <name>Rhythm Pharmaceuticals Inc</name>
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        <name>Rigel Pharmaceuticals Inc</name>
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        <name>Sagimet Biosciences Inc</name>
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        <name>Sana Biotechnology Inc</name>
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        <name>Solid Biosciences Inc</name>
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        <pctVal>0.319031465933</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="32591290.59000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alkermes PLC</name>
        <lei>N/A</lei>
        <title>Alkermes PLC</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="IE00B56GVS15"/>
        </identifiers>
        <balance>2271185.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>118998738.08000000</valUSD>
        <pctVal>1.108523333758</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="6813823.89000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Biohaven Ltd</name>
        <lei>N/A</lei>
        <title>Biohaven Ltd</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="VGG1110E1079"/>
        </identifiers>
        <balance>3790861.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>56408011.68000000</valUSD>
        <pctVal>0.525464371867</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>VG</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="7573.92000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Prothena Corp PLC</name>
        <lei>5299009ZXQ8NIIJ8OL30</lei>
        <title>Prothena Corp PLC</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="IE00B91XRN20"/>
        </identifiers>
        <balance>1453405.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14228834.95000000</valUSD>
        <pctVal>0.132547586711</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="218855.45000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Roivant Sciences Ltd</name>
        <lei>549300DL466NY5J6U724</lei>
        <title>Roivant Sciences Ltd</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="BMG762791017"/>
        </identifiers>
        <balance>3504648.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>124029492.72000000</valUSD>
        <pctVal>1.155386930758</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BM</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CRISPR Therapeutics AG</name>
        <lei>506700O6IRRIQLT3W370</lei>
        <title>CRISPR Therapeutics AG</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="CH0334081137"/>
        </identifiers>
        <balance>2013860.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>109835924.40000000</valUSD>
        <pctVal>1.023167867549</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="46647391.56000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>uniQure NV</name>
        <lei>724500RPCTZLFYJZ3S98</lei>
        <title>uniQure NV</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="NL0010696654"/>
        </identifiers>
        <balance>2396361.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>110376387.66000000</valUSD>
        <pctVal>1.028202510305</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="475891.92000000"/>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>



    </explntrNotes>
    <signature>
      <ncom:dateSigned>2026-07-29</ncom:dateSigned>
      <ncom:nameOfApplicant>SPDR SERIES TRUST</ncom:nameOfApplicant>
      <ncom:signature>Arthur Jensen</ncom:signature>
      <ncom:signerName>Arthur Jensen</ncom:signerName>
      <ncom:title>Deputy Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
