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      <invstOrSec>
        <name>Trevi Therapeutics Inc</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Zevra Therapeutics Inc</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Tarsus Pharmaceuticals Inc</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Avadel Pharmaceuticals PLC</name>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Axsome Therapeutics Inc</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Terns Pharmaceuticals Inc</name>
        <lei>254900S1ZDQMF4MYP709</lei>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>WaVe Life Sciences Ltd</name>
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        <assetCat>EC</assetCat>
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        <invCountry>SG</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Perrigo Co PLC</name>
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        <title>Perrigo Co PLC</title>
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        <assetCat>EC</assetCat>
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        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Nuvation Bio Inc</name>
        <lei>N/A</lei>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Amylyx Pharmaceuticals Inc</name>
        <lei>N/A</lei>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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        <name>State Street Global Advisors</name>
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        <title>State Street Navigator Securities Lending Portfolio II</title>
        <cusip>857492706</cusip>
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        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
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        <fairValLevel>1</fairValLevel>
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        <name>Liquidia Corp</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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        <name>Organon &amp; Co</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Innoviva Inc</name>
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        <title>Innoviva Inc</title>
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        <fairValLevel>1</fairValLevel>
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        <name>Pfizer Inc</name>
        <lei>765LHXWGK1KXCLTFYQ30</lei>
        <title>Pfizer Inc</title>
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        <fairValLevel>1</fairValLevel>
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        <name>Jazz Pharmaceuticals PLC</name>
        <lei>635400GAUMJCLEZRRV50</lei>
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        <name>LENZ Therapeutics Inc</name>
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        <name>Edgewise Therapeutics Inc</name>
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        <name>ALT5 Sigma Corp</name>
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        <title>ALT5 Sigma Corp</title>
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        <name>Xeris Biopharma Holdings Inc</name>
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        <name>Enliven Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Enliven Therapeutics Inc</title>
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        <name>Harmony Biosciences Holdings Inc</name>
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        <title>Harmony Biosciences Holdings Inc</title>
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        <fairValLevel>1</fairValLevel>
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        <name>Arvinas Inc</name>
        <lei>N/A</lei>
        <title>Arvinas Inc</title>
        <cusip>04335A105</cusip>
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      <invstOrSec>
        <name>Nektar Therapeutics</name>
        <lei>5299005I24806IOIYE03</lei>
        <title>Nektar Therapeutics</title>
        <cusip>640268306</cusip>
        <identifiers>
          <isin value="US6402683063"/>
        </identifiers>
        <balance>45616.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>2595550.40000000</valUSD>
        <pctVal>1.481662817327</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Crinetics Pharmaceuticals Inc</name>
        <lei>549300Q1CNFXK5P31D28</lei>
        <title>Crinetics Pharmaceuticals Inc</title>
        <cusip>22663K107</cusip>
        <identifiers>
          <isin value="US22663K1079"/>
        </identifiers>
        <balance>128428.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>5349026.20000000</valUSD>
        <pctVal>3.053476915512</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="470645.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ocular Therapeutix Inc</name>
        <lei>529900ABAWFXOHSIHG03</lei>
        <title>Ocular Therapeutix Inc</title>
        <cusip>67576A100</cusip>
        <identifiers>
          <isin value="US67576A1007"/>
        </identifiers>
        <balance>344443.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4026538.67000000</valUSD>
        <pctVal>2.298538541139</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="267841.28000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Phibro Animal Health Corp</name>
        <lei>549300U24SP4AF2JUX52</lei>
        <title>Phibro Animal Health Corp</title>
        <cusip>71742Q106</cusip>
        <identifiers>
          <isin value="US71742Q1067"/>
        </identifiers>
        <balance>48849.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1976430.54000000</valUSD>
        <pctVal>1.128239945619</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Elanco Animal Health Inc</name>
        <lei>549300SHPNDCE059M934</lei>
        <title>Elanco Animal Health Inc</title>
        <cusip>28414H103</cusip>
        <identifiers>
          <isin value="US28414H1032"/>
        </identifiers>
        <balance>245225.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4938831.50000000</valUSD>
        <pctVal>2.819318397591</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4568898.92000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Merck &amp; Co Inc</name>
        <lei>4YV9Y5M8S0BRK1RP0397</lei>
        <title>Merck &amp; Co Inc</title>
        <cusip>58933Y105</cusip>
        <identifiers>
          <isin value="US58933Y1055"/>
        </identifiers>
        <balance>53493.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4489667.49000000</valUSD>
        <pctVal>2.562914356082</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Eli Lilly &amp; Co</name>
        <lei>FRDRIPF3EKNDJ2CQJL29</lei>
        <title>Eli Lilly &amp; Co</title>
        <cusip>532457108</cusip>
        <identifiers>
          <isin value="US5324571083"/>
        </identifiers>
        <balance>5957.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4545191.00000000</valUSD>
        <pctVal>2.594609799274</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Evolus Inc</name>
        <lei>549300VYQRYBQOT8V419</lei>
        <title>Evolus Inc</title>
        <cusip>30052C107</cusip>
        <identifiers>
          <isin value="US30052C1071"/>
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        <balance>259863.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1595558.82000000</valUSD>
        <pctVal>0.910820370297</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1395536.04000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Royalty Pharma PLC</name>
        <lei>549300FGFN7VOK8BZR03</lei>
        <title>Royalty Pharma PLC</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="GB00BMVP7Y09"/>
        </identifiers>
        <balance>124239.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4383151.92000000</valUSD>
        <pctVal>2.502110235486</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Corcept Therapeutics Inc</name>
        <lei>529900EO9LUTFMZ7FF90</lei>
        <title>Corcept Therapeutics Inc</title>
        <cusip>218352102</cusip>
        <identifiers>
          <isin value="US2183521028"/>
        </identifiers>
        <balance>62762.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5216149.82000000</valUSD>
        <pctVal>2.977624798926</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>State Street Global Advisors</name>
        <lei>549300BZ5TGIFZUZDZ37</lei>
        <title>State Street Institutional US Government Money Market Fund</title>
        <cusip>857492706</cusip>
        <identifiers>
          <isin value="US8574927062"/>
        </identifiers>
        <balance>376105.82000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>376105.82000000</valUSD>
        <pctVal>0.214698974396</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Bristol-Myers Squibb Co</name>
        <lei>HLYYNH7UQUORYSJQCN42</lei>
        <title>Bristol-Myers Squibb Co</title>
        <cusip>110122108</cusip>
        <identifiers>
          <isin value="US1101221083"/>
        </identifiers>
        <balance>95334.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4299563.40000000</valUSD>
        <pctVal>2.454393958415</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>



    </explntrNotes>
    <signature>
      <ncom:dateSigned>2025-10-30</ncom:dateSigned>
      <ncom:nameOfApplicant>SPDR SERIES TRUST</ncom:nameOfApplicant>
      <ncom:signature>Arthur Jensen</ncom:signature>
      <ncom:signerName>Arthur Jensen</ncom:signerName>
      <ncom:title>Deputy Treasurer</ncom:title>
    </signature>
  </formData>
  <documents>XXXX</documents>
</edgarSubmission>
