<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2004-05-18</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001063530</issuerCik>
        <issuerName>POWER 3 MEDICAL PRODUCTS INC</issuerName>
        <issuerTradingSymbol>pwrm</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001059677</rptOwnerCik>
            <rptOwnerName>ADVANCED BIO/CHEM INC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>770 SOUTH POST OAK LANE, SUITE 330</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>HOUSTON</rptOwnerCity>
            <rptOwnerState>TX</rptOwnerState>
            <rptOwnerZipCode>77056</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock, $.001 par value</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>15000000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Effective May 18, 2004, as previously reported on a Current Report on Form 8-K by Power3 Medical Products, Inc. (the &quot;Issuer&quot;), the Issuer purchased all of the assets of Advanced Bio/Chem, Inc. (the &quot;Company&quot;), in consideration for certain representation, warranties, and indemnifications.  The purchase price for such assets of the Company was paid by the Issuer by delivery of 15,000,000 of its shares of common stock, $.001 par value per share, to the Company.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>John Mazzuto</signatureName>
        <signatureDate>2004-05-25</signatureDate>
    </ownerSignature>
</ownershipDocument>

