X0206 3 2024-10-02 0 0001062822 LEXICON PHARMACEUTICALS, INC. LXRX 0001846325 DeFrancesco Lisa 2445 TECHNOLOGY FOREST BLVD 11TH FLOOR SPRING TX 77381 1 VP, IR and Corp Strategy Common Stock 0 D Stock Option (Right to Buy) 1.01 2033-11-13 Common Stock 230000 D Restricted Stock Units Common Stock 74020 D Stock Option (Right to Buy) 2.15 2034-02-08 Common Stock 74020 D Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant (11/13/2024) and vests 1/48th per month for each month of service thereafter. Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant. Each restricted stock unit represents a contingent right to receive one share of common stock. Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant, and vests 1/48th per month for each month of service thereafter. /s/ Lisa M. DeFrancesco 2024-10-07