X0306 4 2021-02-28 0001062822 LEXICON PHARMACEUTICALS, INC. LXRX 0001227372 MAIN ALAN J 8800 TECHNOLOGY FOREST PLACE THE WOODLANDS TX 77381 1 EVP, Innov & Chem Sciences Common Stock 2021-02-28 4 M 0 2497 A 107137 D Common Stock 2021-02-28 4 M 0 8297 A 115434 D Common Stock 2021-02-28 4 M 0 22374 A 137808 D Common Stock 2021-02-28 4 M 0 23300 A 161108 D Common Stock 2021-02-28 4 F 0 20413 7.19 D 140695 D Restricted Stock Units 2021-02-28 4 M 0 2497 D Common Stock 2497 0 D Restricted Stock Units 2021-02-28 4 M 0 8297 D Common Stock 8297 0 D Restricted Stock Units 2021-02-28 4 M 0 22374 D Common Stock 22374 22373 D Restricted Stock Units 2021-02-28 4 M 0 23300 D Common Stock 23300 46600 D Each restricted stock unit represents a contingent right to receive one share of common stock. Withholding of a portion of issued shares by the Company in satisfaction of shareholder's tax withholding obligations with respect thereto. Restricted stock units vest with respect to 25% of the shares subject to the restricted stock units on February 28, 2018 and vest an additional 25% on February 28 of each of the three succeeding years thereafter. Restricted stock units vest with respect to one third of the shares subject to the restricted stock units on February 28, 2019 and vest an additional one third on February 28 of each of the two succeeding years thereafter. Restricted stock units vest with respect to one third of the shares subject to the restricted stock units on February 28, 2020 and vest an additional one third on February 28 of each of the two succeeding years thereafter. Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant. /s/ Alan J. Main, Ph.D. 2021-03-02