X0306 4 2020-02-06 0001062822 LEXICON PHARMACEUTICALS, INC. LXRX 0001516368 Lapuerta Pablo 8800 TECHNOLOGY FOREST PLACE THE WOODLANDS TX 77381 1 EVP and CMO Restricted Stock Units 2020-02-06 4 A 0 82410 0 A Common Stock 82410 82410 D Stock Option (Right to Buy) 3.31 2020-02-06 4 A 0 247220 0 A 2030-02-06 Common Stock 247220 247220 D Each restricted stock unit represents a contingent right to receive one share of common stock. Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant. Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant, and vests 1/48th per month for each month of service thereafter. /s/ Pablo Lapuerta, M.D. 2020-02-10