X0306 4 2019-08-16 0001062822 LEXICON PHARMACEUTICALS, INC. LXRX 0001612528 COATS LONNEL 8800 TECHNOLOGY FOREST PLACE THE WOODLANDS TX 77381 1 1 President and CEO Common Stock 2019-08-16 4 P 0 156 1.325 A 87695 D Common Stock 2019-08-16 4 P 0 10044 1.33 A 97739 D Common Stock 2019-08-16 4 P 0 100 1.335 A 97839 D Common Stock 2019-08-16 4 P 0 6600 1.34 A 104439 D Common Stock 2019-08-16 4 P 0 600 1.345 A 105039 D Common Stock 2019-08-16 4 P 0 3500 1.35 A 108539 D Common Stock 2019-08-16 4 P 0 16000 1.36 A 124539 D Common Stock 2019-08-19 4 P 0 3000 1.398 A 127539 D /s/ Lonnel Coats 2019-08-20