X0306 4 2018-02-08 0001062822 LEXICON PHARMACEUTICALS, INC. LXRX 0001225767 WADE JEFFREY L 8800 TECHNOLOGY FOREST PLACE THE WOODLANDS TX 77381 1 EVP, Corp Adm Affairs and CFO Restricted Stock Units 2018-02-08 4 A 0 28665 0 A Common Stock 28665 28665 D Stock Option (Right to Buy) 9.79 2018-02-08 4 A 0 79550 0 A 2028-02-08 Common Stock 79550 79550 D Each restricted stock unit represents a contingent right to receive one share of common stock. Restricted stock units vest with respect to one third of the shares subject to the restricted stock units on February 28, 2019 and vest an additional one third on February 28 of each of the two succeeding years thereafter. Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant (2/8/2019) and vests 1/48th per month for each month of service thereafter. /s/ Jeffrey L. Wade 2018-02-12