X0306 4 2016-02-29 0001062822 LEXICON PHARMACEUTICALS, INC. LXRX 0001225767 WADE JEFFREY L 8800 TECHNOLOGY FOREST PLACE THE WOODLANDS TX 77381 1 EVP, Corp Adm Affairs and CFO Common Stock 2016-02-29 4 M 0 2785 A 32044 D Common Stock 2016-02-29 4 M 0 2428 A 34472 D Common Stock 2016-02-29 4 M 0 2929 A 37401 D Common Stock 2016-02-29 4 M 0 5807 A 43208 D Common Stock 2016-02-29 4 F 0 3815 9.07 D 39393 D Restricted Stock Units (Phantom Stock) 2016-02-29 4 M 0 2785 D Common Stock 2785 0 D Restricted Stock Units (Phantom Stock) 2016-02-29 4 M 0 2428 D Common Stock 2428 2429 D Restricted Stock Units (Phantom Stock) 2016-02-29 4 M 0 2929 D Common Stock 2929 5857 D Restricted Stock Units (Phantom Stock) 2016-02-29 4 M 0 5807 D Common Stock 5807 17421 D Each restricted stock unit represents a contingent right to receive one share of common stock. Withholding of a portion of issued shares by the Company in satisfaction of shareholder's tax withholding obligations with respect thereto. Restricted stock units vest with respect to 25% of the shares subject to the restricted stock units on February 28, 2013 and vest an additional 25% on February 28 of each of the three succeeding years thereafter. Restricted stock units vest with respect to 25% of the shares subject to the restricted stock units on February 28, 2014 and vest an additional 25% on February 28 of each of the three succeeding years thereafter. Restricted stock units vest with respect to 25% of the shares subject to the restricted stock units on February 28, 2015 and vest an additional 25% on February 28 of each of the three succeeding years thereafter. Restricted stock units vest with respect to 25% of the shares subject to the restricted stock units on February 28, 2016 and vest an additional 25% on February 28 of each of the three succeeding years thereafter. /s/ Jeffrey L. Wade 2016-03-01