X0306 4 2022-08-05 0 0001062822 LEXICON PHARMACEUTICALS, INC. LXRX 0001839806 Invus US Partners LLC C/O THE INVUS GROUP, LLC 750 LEXINGTON AVENUE 30TH FLOOR NEW YORK NY 10022 1 0 1 0 0001340098 Ulys, L.L.C. 750 LEXINGTON AVENUE, 30TH FLOOR NEW YORK NY 10022 1 0 1 0 0001053890 DEBBANE RAYMOND C/O ULYS, L.L.C. 750 LEXINGTON AVENUE, 30TH FLOOR NEW YORK NY 10022 1 0 1 0 Common Stock 2022-08-05 4 P 0 147390 2.50 A 5451204 I See Footnotes Common Stock 331545 D Pursuant to a purchase agreement dated July 27, 2022, between Invus US Partners LLC and the Issuer, on August 5, 2022, Invus US Partners LLC purchased an additional 147,390 shares of common stock, $0.001 par value per share (the "Issuer Common Stock"), following the full exercise by the underwriters of a concurrent public offering of their option to purchase additional shares of Issuer Common Stock. These securities are directly held by Invus US Partners LLC These securities are directly held by Mr. Raymond Debbane. Ulys, L.L.C. is the general partner of Invus US Partners LLC, and Mr. Raymond Debbane is the sole member of Ulys, L.L.C. Each of the Reporting Persons (other than to the extent it directly holds securities reported herein) disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such Reporting Person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), each of the Reporting Persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose. Artal International S.C.A. directly holds 50,859,331 shares of Issuer Common Stock; Invus, L.P. directly holds 35,402,689 shares of Issuer Common Stock; and Invus Public Equities, L.P. directly holds 3,516,214 shares of Issuer Common Stock, which securities are being reported on a separately filed Form 4. For purposes of Section 16 of the Exchange Act, the Reporting Persons may be deemed to be directors by deputization of the Issuer by virtue of Invus, L.P.'s right to designate certain members of the Issuer's board of directors pursuant to a stockholders' agreement between the Issuer and Invus, L.P. Invus US Partners LLC, By: /s/ Philip Bafundo , Name: Philip Bafundo, Title: Authorized Person 2022-08-09 ULYS, L.L.C., By: /s/ Raymond Debbane, Name: Raymond Debbane, Title: President 2022-08-09 RAYMOND DEBBANE, /s/ Raymond Debbane 2022-08-09