144 0001522780 XXXXXXXX LIVE 0001061983 CYTOKINETICS, INCORPORATED 000-50633 350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080 6506243000 EDWARD KAYE Director Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

5175 321885.00 122264929 11/11/2025 NASDAQ Common 11/11/2025 Exercise of Stock Options Issuer N 5175 11/11/2025 Cash N 10b5-1 Sales for EDWARD KAYE

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 10/06/2025 6757 405420.00 10b5-1 Sales for EDWARD KAYE

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 09/30/2025 6695 368727.79 10b5-1 Sales for EDWARD KAYE

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 09/02/2025 6756 337800.00 Sales that were executed on November 11, 2025 are being reported on this Form 144 filed on November 12, 2025 given the EDGAR system was not accepting filings on November 11, 2025 in observance of the federal holiday. 11/11/2025 03/06/2025 /s/ Edward Kaye