144 0001551778 XXXXXXXX LIVE 0001061983 CYTOKINETICS INC 000-50633 350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080 6506243000 FADY MALIK Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

11000 652850.00 119657156 10/21/2025 NASDAQ Common 10/21/2025 Exercise of Stock Options Issuer N 11000 10/21/2025 Cash N 10b5-1 Sales for FADY MALIK

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 10/07/2025 2000 121120.00 10b5-1 Sales for FADY MALIK

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 09/23/2025 2000 98554.80 10b5-1 Sales for FADY MALIK

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 09/09/2025 2000 102573.60 10b5-1 Sales for FADY MALIK

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 08/19/2025 2000 76627.00 10b5-1 Sales for FADY MALIK

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 08/05/2025 2000 72680.00 10b5-1 Sales for FADY MALIK

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 07/22/2025 2000 74931.60 The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. 10/21/2025 09/16/2024 /s/ Fady Malik