X0508 4 2025-05-14 0001061983 CYTOKINETICS INC CYTK 0001235945 WIERENGA WENDALL 350 OYSTER POINT BLVD SOUTH SAN FRANCISCO CA 94080 1 0 Common Stock 2025-05-14 4 A 0 7333 0 A 32181 D Non-Qualified Stock Option (Right to Buy) 30.00 2025-05-14 4 A 0 10880 0 A 2025-06-16 2035-05-13 Common Stock 10880 10880 D Comprised of restricted stock units ("RSUs") that will vest in one installment on the earlier to occur of (x) the one-year anniversary of the grant date and (y) the date of the issuer's annual meeting of stockholders for the calendar year immediately subsequent to the grant date, subject to the director's continuous service as a member of the issuer's Board of Directors. RSUs convert to shares of common stock on a 1:1 basis upon vesting. Comprised of stock options that will vest monthly in equal installments over a period commencing on the grant date and ending on the earlier to occur of (x) the one-year anniversary of the date of the grant and (y) the date of the issuer's annual meeting of stockholders for the calendar year immediately subsequent to the grant date, subject to the director's continuous service as a member of the issuer's Board of Directors. /s/ John O. Faurescu, attorney-in-fact for Dr. Wierenga 2025-05-14