X0508 4 2025-03-14 0001061983 CYTOKINETICS INC CYTK 0001288859 Blum Robert I 350 OYSTER POINT BLVD SOUTH SAN FRANCISCO CA 94080 1 1 President & CEO 0 Common Stock 2025-03-14 4 A 0 116096 0 A 480277 D Common Stock 2083 I by Trust 1 Common Stock 2083 I by Trust 2 Incentive Stock Option (Right to Buy) 44.36 2025-03-14 4 A 0 2254 0 A 2025-04-14 2035-03-13 Common Stock 2254 2254 D Non-Qualified Stock Option (Right to Buy) 44.36 2025-03-14 4 A 0 176547 0 A 2025-04-14 2035-03-13 Common Stock 176547 176547 D Comprised of restricted stock units that convert to shares of common stock on a 1:1 basis upon vesting. 40% of the RSUs will vest on the 1-year anniversary of the date of grant; an additional 40% of the RSUs will vest on the 2-year anniversary of the date of grant; and the final 20% of the RSUs will vest on the 3-year anniversary of the date of grant, in each case subject to Mr. Blum's continued employment with the company on the scheduled vesting date. Shares held by The Bridget Blum 2003 Irrevocable Trust. Shares held by The Brittany Blum 2003 Irrevocable Trust. Stock options vest in equal monthly installments over 48 months from the date of grant, subject to Mr. Blum's continued employment with the company on the scheduled vesting date. Stock options vest in equal monthly installments over 48 months from the date of grant, subject to Mr. Blum's continued employment with the company on the scheduled vesting date. /s/ John O. Faurescu, attorney-in-fact for Mr. Blum 2025-03-18