X0306 4 2022-07-01 0001061983 CYTOKINETICS INC CYTK 0001243004 SMITH SANDFORD D 350 OYSTER POINT BLVD SOUTH SAN FRANCISCO CA 94080 1 Common Stock 2022-07-01 4 A 0 137 41.00 A 12170 D Shares issued at Reporting Person's election pursuant to Issuer's stock in lieu of cash for all or part of directors' annual base retainer program. Share are fully vested from the moment of grant. Shares are issued at per share price of $41.00, representing the closing stock price of the Issuer's common stock on July 1, 2022. /s/ John Faurescu, attorney-in-fact for Mr. Smith 2022-07-12