X0303 4 2010-01-04 0 0001061983 CYTOKINETICS INC CYTK 0001288531 SPUDICH JAMES A 280 EAST GRAND AVENUE SOUTH SAN FRANCISCO CA 94080 1 0 0 0 Common Stock 180600 D Non-Qualified Stock Option (right to buy) 3.11 2010-01-04 4 A 0 16077 1.244 A 2010-02-04 2020-01-04 Common Stock 16077 16077 D Non-Qualified Stock Option (right to buy) 1.2 2002-07-10 2012-07-10 Common Stock 10000 10000 D Non-Qualified Stock Option (right to buy) 1.85 2009-06-21 2019-05-21 Common Stock 15000 15000 D Non-Qualified Stock Option (right to buy) 2.85 2009-02-02 2019-01-02 Common Stock 17543 17543 D Non-Qualified Stock Option (right to buy) 3.73 2008-08-01 2018-07-01 Common Stock 6702 6702 D Non-Qualified Stock Option (right to buy) 3.83 2008-06-22 2018-05-22 Common Stock 15000 15000 D Non-Qualified Stock Option (right to buy) 5.55 2005-05-19 2015-05-19 Common Stock 7500 7500 D Non-Qualified Stock Option (right to buy) 6.55 2007-05-24 2017-05-24 Common Stock 10000 10000 D Non-Qualified Stock Option (right to buy) 7.29 2006-05-25 2016-05-25 Common Stock 7500 7500 D This option shall vest and become exercisable as to 16,077 shares divided into equal monthly installments such that the option shall be 100% vested on January 4, 2011. This option was issued to the reporting person pursuant to the Cytokinetics 2004 Equity Incentive Plan in lieu of annual retainer of $20,000. This option is immediately exercisable upon grant and shall vest as to 417 shares on 06/01/02 and the balance of 9,583 divided into equal monthly installments thereafter such that the option shall be 100% vested on 05/01/04. This option shall vest and become exercisable as to 15,000 shares divided into equal monthly installments such that the option shall be 100% vested on May 21, 2010. This option shall vest and become exercisable as to 17,543 shares divided into equal monthly installments such that the option shall be 100% vested on January 2, 2010. This option shall vest and become exercisable as to 6,702 shares divided into equal monthly installments such that the option shall be 100% vested on January 1, 2009. This option shall vest and become exercisable as to 15,000 shares divided into equal monthly installments such that the option shall be 100% vested on May 22, 2009. By: Sharon Barbari For: James A. Spudich, Ph.D. 2010-01-04