Consolidated Statements Of Operations (USD $) In Thousands, except Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
Revenues
Net product sales	$ 43,241	$ 0	$ 0
Collaboration and license agreement revenues	51,537	107,470	51,965
Total revenues	94,778	107,470	51,965
Costs and expenses
Cost of sales	3,115	0	0
Research and development	163,396	146,410	119,139
Selling, general and administrative	72,659	29,258	17,683
Total costs and expenses	239,170	175,668	136,822
Loss from operations	(144,392)	(68,198)	(84,857)
Investment income (loss), net	(7,638)	1,933	3,174
Net loss	$ (152,030)	$ (66,265)	$ (81,683)
Net loss per share - basic and diluted	$ (1.34)	$ (0.66)	$ (0.90)
Shares used in computation of net loss per share - basic and diluted	113,098	101,055	90,988