-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, AEDxYlAYYKtOmIjocEd2AFLdtXU0CHIhRND0TLs+tjjme+IkJZhhuN0UGM++UqDb rBNwQb+YGNjShe+9BwUX7w== 0000950005-02-000408.txt : 20020416 0000950005-02-000408.hdr.sgml : 20020416 ACCESSION NUMBER: 0000950005-02-000408 CONFORMED SUBMISSION TYPE: SC 13G/A PUBLIC DOCUMENT COUNT: 1 FILED AS OF DATE: 20020410 GROUP MEMBERS: ALIX MARDUEL GROUP MEMBERS: ALTA BIOPHARMA MANAGEMENT PARTNERS, LLC GROUP MEMBERS: ALTA BIOPHARMA PARTNERS, L.P. GROUP MEMBERS: ALTA EMBARCADERO BIOPHARMA PARTNERS, LLC GROUP MEMBERS: ALTA PARTNERS GROUP MEMBERS: ALTA/CHASE BIOPHARMA MANAGEMENT, LLC GROUP MEMBERS: DANIEL JANNEY GROUP MEMBERS: GARRETT GRUENER GROUP MEMBERS: GUY NOHRA GROUP MEMBERS: JEAN DELEAGE GROUP MEMBERS: THE MEDICINES COMPANY CHASE PARTNERS (ALTA BIO), LLC SUBJECT COMPANY: COMPANY DATA: COMPANY CONFORMED NAME: MEDICINES CO/ MA CENTRAL INDEX KEY: 0001113481 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 043324394 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G/A SEC ACT: 1934 Act SEC FILE NUMBER: 005-60201 FILM NUMBER: 02606764 BUSINESS ADDRESS: STREET 1: ONE CAMBRIDGE CTR CITY: CAMBRIDGE STATE: MA ZIP: 02142 BUSINESS PHONE: 6172259099 FILED BY: COMPANY DATA: COMPANY CONFORMED NAME: ALTA PARTNERS CENTRAL INDEX KEY: 0001060013 IRS NUMBER: 943238854 STATE OF INCORPORATION: CA FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G/A BUSINESS ADDRESS: STREET 1: ONE EMBARCADERO CENTER STREET 2: STE 4050 CITY: SAN FRANCISCO STATE: CA ZIP: 94111 BUSINESS PHONE: 4153624022 MAIL ADDRESS: STREET 1: ONE EMBARCADERO CENTER STREET 2: STE 4050 CITY: SAN FRANCISCO STATE: CA ZIP: 94111 SC 13G/A 1 p15256_sc13g.txt UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G (Amendment No. _2_)* UNDER THE SECURITIES EXCHANGE ACT OF 1934 THE MEDICINES COMPANY ----------------------------------------- (Name of Issuer) Common Stock ----------------------------------------- (Title of Class of Securities) 58468810 ----------------------------------------- (CUSIP Number)
CUSIP No. 58468810 Page 2 of 16 Pages - ------------------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta Partners - ------------------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ------------------------------------------------------------------------------------------------------------------- (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization California - ------------------------------------------------------------------------------------------------------------------- EXIT FILING --- Please see Attachment A Number Of Shares (5) Sole Voting Power -0- Beneficially Owned By Each Reporting (6) Shared Voting Power 837,906 Person With (7) Sole Dispositive Power -0- (8) Shared Dispositive Power 837,906 (9) Aggregate Amount Beneficially Owned By Each Reporting Person 837,906 EXIT FILING --- Please see Attachment A - ------------------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ------------------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 2.4% EXIT FILING --- Please see Attachment A - ------------------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person IA - ------------------------------------------------------------------------------------------------------------------- *SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP No.58468810 Page 3 of 16 Pages - ------------------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta BioPharma Partners, L.P. - ------------------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ------------------------------------------------------------------------------------------------------------------- (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization Delaware - ------------------------------------------------------------------------------------------------------------------- EXIT FILING --- Please see Attachment A Number Of Shares (5) Sole Voting Power -0- Beneficially Owned By Each Reporting (6) Shared Voting Power 837,906 Person With (7) Sole Dispositive Power -0- (8) Shared Dispositive Power 837,906 (9) Aggregate Amount Beneficially Owned By Each Reporting Person 837,906 EXIT FILING --- Please see Attachment A - ------------------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ------------------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 2.4% EXIT FILING --- Please see Attachment A - ------------------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person PN - -------------------------------------------------------------------------------------------------------------------
CUSIP No. 58468810 Page 4 of 16 Pages - ------------------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta BioPharma Management Partners, LLC. - ------------------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ------------------------------------------------------------------------------------------------------------------- (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization Delaware - ------------------------------------------------------------------------------------------------------------------- EXIT FILING --- Please see Attachment A Number Of Shares (5) Sole Voting Power 837,906 Beneficially Owned By Each Reporting (6) Shared Voting Power -0- Person With (7) Sole Dispositive Power 837,906 (8) Shared Dispositive Power -0- (9) Aggregate Amount Beneficially Owned By Each Reporting Person 837,906 EXIT FILING --- Please see Attachment A - ------------------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ------------------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 2.4% EXIT FILING --- Please see Attachment A - ------------------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person CO - -------------------------------------------------------------------------------------------------------------------
CUSIP No. 58468810 Page 5 of 16 Pages - ------------------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons The Medicines Company Chase Partners (Alta Bio), LLC - ------------------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ------------------------------------------------------------------------------------------------------------------- (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization Delaware - ------------------------------------------------------------------------------------------------------------------- EXIT FILING --- Please see Attachment A Number Of Shares (5) Sole Voting Power -0- Beneficially Owned By Each Reporting (6) Shared Voting Power 837,906 Person With (7) Sole Dispositive Power -0- (8) Shared Dispositive Power 837,906 (9) Aggregate Amount Beneficially Owned By Each Reporting Person 837,906 EXIT FILING --- Please see Attachment A - ------------------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ------------------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 2.4% EXIT FILING --- Please see Attachment A - ------------------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person CO - -------------------------------------------------------------------------------------------------------------------
CUSIP No. 58468810 Page 6 of 16 Pages - ------------------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta Embarcadero BioPharma Partners, LLC - ------------------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ------------------------------------------------------------------------------------------------------------------- (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization California - ------------------------------------------------------------------------------------------------------------------- EXIT FILING --- Please see Attachment A Number Of Shares (5) Sole Voting Power -0- Beneficially Owned By Each Reporting (6) Shared Voting Power 837,906 Person With (7) Sole Dispositive Power -0- (8) Shared Dispositive Power 837,906 (9) Aggregate Amount Beneficially Owned By Each Reporting Person 837,906 EXIT FILING --- Please see Attachment A - ------------------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ------------------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 2.4% EXIT FILING --- Please see Attachment A - ------------------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person CO - -------------------------------------------------------------------------------------------------------------------
CUSIP No. 58468810 Page 7 of 16 Pages - ------------------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta/Chase BioPharma Management, LLC - ------------------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ------------------------------------------------------------------------------------------------------------------- (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization Delaware - ------------------------------------------------------------------------------------------------------------------- EXIT FILING --- Please see Attachment A Number Of Shares (5) Sole Voting Power -0- Beneficially Owned By Each Reporting (6) Shared Voting Power 837,906 Person With (7) Sole Dispositive Power -0- (8) Shared Dispositive Power 837,906 (9) Aggregate Amount Beneficially Owned By Each Reporting Person 837,906 EXIT FILING --- Please see Attachment A - ------------------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ------------------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 2.4% EXIT FILING --- Please see Attachment A - ------------------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person CO - -------------------------------------------------------------------------------------------------------------------
CUSIP No. 58468810 Page 8 of 16 Pages - ------------------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Jean Deleage - ------------------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ------------------------------------------------------------------------------------------------------------------- (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization United States - ------------------------------------------------------------------------------------------------------------------- EXIT FILING --- Please see Attachment A Number Of Shares (5) Sole Voting Power 10,172 Beneficially Owned By Each Reporting (6) Shared Voting Power 837,906 Person With (7) Sole Dispositive Power 10,172 (8) Shared Dispositive Power 837,906 (9) Aggregate Amount Beneficially Owned By Each Reporting Person 848,078 EXIT FILING --- Please see Attachment A - ------------------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ------------------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 2.4% EXIT FILING --- Please see Attachment A - ------------------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person IN - ------------------------------------------------------------------------------------------------------------------- *SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP No. 58468810 Page 9 of 16 Pages - ------------------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Garrett Gruener - ------------------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ------------------------------------------------------------------------------------------------------------------- (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization United States - ------------------------------------------------------------------------------------------------------------------- EXIT FILING --- Please see Attachment A Number Of Shares (5) Sole Voting Power 13,742 Beneficially Owned By Each Reporting (6) Shared Voting Power 837,906 Person With (7) Sole Dispositive Power 13,742 (8) Shared Dispositive Power 837,906 (9) Aggregate Amount Beneficially Owned By Each Reporting Person 851,648 EXIT FILING --- Please see Attachment A - ------------------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ------------------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 2.5% EXIT FILING --- Please see Attachment A - ------------------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person IN - ------------------------------------------------------------------------------------------------------------------- *SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP No. 58468810 Page 10 of 16 Pages - ------------------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Daniel Janney - ------------------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ------------------------------------------------------------------------------------------------------------------- (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization United States - ------------------------------------------------------------------------------------------------------------------- EXIT FILING --- Please see Attachment A Number Of Shares (5) Sole Voting Power 18,070 Beneficially Owned By Each Reporting (6) Shared Voting Power 837,906 Person With (7) Sole Dispositive Power 18,070 (8) Shared Dispositive Power 837,906 (9) Aggregate Amount Beneficially Owned By Each Reporting Person 855,976 EXIT FILING --- Please see Attachment A - ------------------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ------------------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 2.5% EXIT FILING --- Please see Attachment A - ------------------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person IN - ------------------------------------------------------------------------------------------------------------------- *SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP No. 58468810 Page 11 of 16 Pages - ------------------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alix Marduel - ------------------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ------------------------------------------------------------------------------------------------------------------- (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization United States - ------------------------------------------------------------------------------------------------------------------- EXIT FILING --- Please see Attachment A Number Of Shares (5) Sole Voting Power 18,070 Beneficially Owned By Each Reporting (6) Shared Voting Power 837,906 Person With (7) Sole Dispositive Power 18,070 (8) Shared Dispositive Power 837,906 (9) Aggregate Amount Beneficially Owned By Each Reporting Person 855,976 EXIT FILING --- Please see Attachment A - ------------------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ------------------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 2.5% EXIT FILING --- Please see Attachment A - ------------------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person IN - ------------------------------------------------------------------------------------------------------------------- *SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP No. 58468810 Page 12 of 16 Pages - ------------------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Guy Nohra - ------------------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ------------------------------------------------------------------------------------------------------------------- (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization United States - ------------------------------------------------------------------------------------------------------------------- EXIT FILING --- Please see Attachment A Number Of Shares (5) Sole Voting Power 13,251 Beneficially Owned By Each Reporting (6) Shared Voting Power 837,906 Person With (7) Sole Dispositive Power 13,251 (8) Shared Dispositive Power 837,906 (9) Aggregate Amount Beneficially Owned By Each Reporting Person 851,157 EXIT FILING --- Please see Attachment A - ------------------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ------------------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 2.5% EXIT FILING --- Please see Attachment A - ------------------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person IN - ------------------------------------------------------------------------------------------------------------------- *SEE INSTRUCTION BEFORE FILLING OUT!
Item 1. (a) Name of Issuer: The Medicines Company ("Issuer") (b) Address of Issuer's Principal Executive Offices: One Cambridge Center Cambridge, MA 02142 Item 2. (a) Name of Person Filing: Alta Partners ("AP") Alta BioPharma Partners, L.P. ("ABP") Alta BioPharma Management Partners, LLC. ("ABMP") Alta Embarcadero BioPharma Partners, LLC ("AEBP") The Medicines Company Chase Partners (Alta Bio), LLC ("MCCP") Alta/Chase BioPharma Management, LLC ("ACMP") Jean Deleage ("JD") Garrett Gruener ("GG") Dan Janney ("DJ") Alix Marduel ("AM") Guy Nohra ("GN") (b) Address of Principal Business Office: One Embarcadero Center, Suite 4050 San Francisco, CA 94111 (c) Citizenship/Place of Organization: Entities: AP California ABP Delaware ABMP Delaware AEBP California MCCP Delaware ACMP Delaware Individuals: JD United States GG United States DJ United States AM United States GN United States (d) Title of Class of Securities: Common Stock (e) CUSIP Number: 58468810 (f) Item 3. Not applicable. Item 4. Ownership.
EXIT FILING --- Please see Attachment A - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- AP ABP ABMP AEBP MCCP ACMP - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- (a) Beneficial Ownership 837,906 837,906 837,906 837,906 837,906 837,906 - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- (b) Percentage of Class 2.4% 2.4% 2.4% 2.4% 2.4% 2.4% - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- (c) Sole Voting Power -0- -0- -0- -0- -0- -0- - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- Shared Voting Power 837,906 837,906 837,906 837,906 837,906 837,906 - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- Sole Dispositive Power -0- -0- -0- -0- -0- -0- - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- Shared Dispositive Power 837,906 837,906 837,906 837,906 837,906 837,906 - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- JD GG DJ AM GN - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- (a) Beneficial Ownership 848,078 851,648 855,976 855,976 851,157 - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- (b) Percentage of Class 2.4% 2.5% 2.5% 2.5% 2.5% - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- (c) Sole Voting Power 10,172 13,742 18,070 18,070 13,251 - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- Shared Voting Power 837,906 837,906 837,906 837,906 837,906 - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- Sole Dispositive Power 10,172 13,742 18,070 18,070 13,251 - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- Shared Dispositive Power 837,906 837,906 837,906 837,906 837,906 - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
EXIT FILING Item 5. Ownership of Five Percent or Less of a Class Exit Filing Item 6. Ownership of More than Five Percent on Behalf of Another Person Not applicable. Item 7. Identification and Classification of the Subsidiary, Which Acquired the Security Being Reported on By the Parent Holding Company. Not applicable. Item 8. Identification and Classification of Members of the Group Not Applicable. Item 9. Notice of Dissolution of Group Not applicable. Item 10. Certification By signing below we certify that, to the best of our knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. EXHIBITS A: Joint Filing Statement Signature After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. Date: April 4, 2002
ALTA PARTNERS ALTA BIOPHARMA PARTNERS, L.P. By: Alta BioPharma Management Partners, LLC By: /s/ Jean Deleage By: /s/ Alix Marduel ----------------------------------------- -------------------------------------------- Jean Deleage, President Alix Marduel, Managing Director ALTA BIOPHARMA MANAGEMENT PARTNERS, LLC ALTA EMBARCADERO BIOPHARMA PARTNERS, LLC By: /s/ Alix Marduel By: /s/ Jean Deleage ----------------------------------------- -------------------------------------------- Alix Marduel, Member Jean Deleage, Member THE MEDICINES COMPANYCHASE PARTNERS (ALTA BIO), LLC ALTA/CHASE BIOPHARMA MANAGEMENT, LLC By: Alta/Chase BioPharma Management, LLC By: /s/ Alix Marduel By: /s/ Alix Marduel ----------------------------------------- -------------------------------------------- Alix Marduel, Member Alix Marduel, Member /s/ Jean Deleage /s/ Guy Nohra - -------------------------------------------- ----------------------------------------------- Jean Deleage Guy Nohra /s/ Garrett Gruener /s/ Alix Marduel - -------------------------------------------- ----------------------------------------------- Garrett Gruener Alix Marduel /s/ Daniel Janney - -------------------------------------------- Daniel Janney
EXHIBIT A AGREEMENT OF JOINT FILING We, the undersigned, hereby express our agreement that the attached Schedule 13G is filed on behalf of us. Date: April 4, 2002
ALTA PARTNERS ALTA BIOPHARMA PARTNERS, L.P. By: Alta BioPharma Management Partners, LLC By: /s/ Jean Deleage By: /s/ Alix Marduel ----------------------------------------- ----------------------------------------- Jean Deleage, President Alix Marduel, Managing Director ALTA BIOPHARMA MANAGEMENT PARTNERS, LLC ALTA EMBARCADERO BIOPHARMA PARTNERS, LLC By: /s/ Alix Marduel By: /s/ Jean Deleage ----------------------------------------- ----------------------------------------- Alix Marduel, Member Jean Deleage, Member THE MEDICINES COMPANYCHASE PARTNERS (ALTA BIO), LLC ALTA/CHASE BIOPHARMA MANAGEMENT, LLC By: Alta/Chase BioPharma Management, LLC By: /s/ Alix Marduel By: /s/ Alix Marduel ----------------------------------------- ----------------------------------------- Alix Marduel, Member Alix Marduel, Member /s/ Jean Deleage /s/ Guy Nohra - -------------------------------------------- -------------------------------------------- Jean Deleage Guy Nohra /s/ Garrett Gruener /s/ Alix Marduel - -------------------------------------------- -------------------------------------------- Garrett Gruener Alix Marduel /s/ Daniel Janney - -------------------------------------------- Daniel Janney
Attachment A EXIT FILING Alta Partners provides investment advisory services to several venture capital funds including Alta BioPharma Partners, L.P., The Medicines Company Chase Partners (Alta Bio), LLC and Alta Embarcadero BioPharma Partners, LLC. Stock Sale: On March 28, 2002, Alta BioPharma Partners, L.P. sold 41,958 shares of Common Stock, The Medicines Company Chase Partners (Alta Bio), LLC sold 23,961 shares of Common Stock, and Alta Embarcadero BioPharma Partners, LLC sold 1,581 shares of Common Stock. These shares were sold on the public stock market. Stock Distribution: On April 2, 2002, Alta BioPharma Partners, L.P. distributed 1,041,792 shares of Common Stock to its general and limited partners. The Medicines Company Chase Partners (Alta Bio), LLC distributed 594,962 shares of Common Stock to its members. Alta Embarcadero BioPharma Partners, LLC distributed 39,265 shares of Common Stock to its members. As a result of the Stock Sale and Stock Distribution Alta Partners is no longer a 5% owner of the Company: Alta BioPharma Partners, L.P. beneficially owns 341,844 shares of Common Stock and Warrants for 178,987 shares of Common Stock. The Medicines Company Chase Partners (Alta Bio), LLC beneficially owns 195,226 shares of Common Stock and Warrants for 102,218 shares of Common Stock. Alta Embarcadero BioPharma Partners, LLC beneficially owns 12,885 shares of Common Stock and Warrants for 6,746 shares of Common Stock. The respective general partners and managing members of Alta BioPharma Partners, L.P., The Medicines Company Chase Partners (Alta Bio), LLC and Alta Embarcadero BioPharma Partners, LLC exercise sole voting and investment power with respect to the shares owned by such funds. Certain Principals of Alta Partners are managing directors of Alta BioPharma Management, LLC (the general partner of Alta BioPharma Partners, L.P.), managing members of Alta/Chase Management, LLC (the managing member of The Medicines Company Chase Partners (Alta Bio), LLC), and members of Alta Embarcadero BioPharma, LLC. As managing directors, managing members and members (respectively), they may be deemed to share voting and investment powers over the shares held by the funds. These principals disclaim beneficial ownership of all such shares held by the aforementioned funds, except to the extent of their proportionate pecuniary interests therein. Mr. Jean Deleage is a managing director of Alta BioPharma Management, LLC (which is the general partner of Alta BioPharma Partners, L.P.), a managing director of Alta/Chase Management, LLC (which is the managing member of The Medicines Company Chase Partners (Alta Bio), LLC) and a member of Alta Embarcadero BioPharma Partners, LLC. Thus he shares voting and dispositive powers over the 341,844 shares of Common Stock and the Warrants for 178,987 shares of Common Stock beneficially owed by Alta BioPharma Partners, L.P.; the 195,226 shares of Common Stock and the Warrants for 102,218 shares of Common Stock beneficially owned by The Medicines Company Chase Partners (Alta Bio), LLC; and the 12,885 shares of Common Stock and the Warrants for 6,746 shares of Common Stock beneficially owned by Alta Embarcadero BioPharma Partners, LLC. Mr. Deleage disclaims beneficial ownership of the shares held by the aforementioned funds except to the extent of his proportionate pecuniary interests therein. On April 2, 2002, Mr. Deleage received 10,172 shares of Common Stock, which was his proportionate pecuniary interest in the stock distributions for Alta Embarcadero BioPharma Partners, LLC, Alta BioPharma Management, LLC and Alta/Chase BioPharma Management, LLC. See next page for disclosure of share ownership. Page 1 of 3 of Attachment A Page 2 of 3 of Attachment A As of April 2, 2002 --- Common Stock Ownership: Shares Owned by / Affiliated with Jean Deleage
Beneficial Owner (issued in the name of) # of Shares Date Acquired Jean Deleage 10,172 April 2, 2002 Deleage Children's Trust FBO Andre Deleage (1) 2,711 April 2, 2002 Deleage Children's Trust FBO Emmanuel Deleage (1) 2,711 April 2, 2002 Deleage Children's Trust FBO Phillippe Deleage (1) 2,711 April 2, 2002 Deleage Children's Trust FBO Michel Deleage (1) 2,710 April 2, 2002
(1) Of which Mr. Deleage, a principal of Alta Partners (a venture capital firm) is neither a trustee nor claims any beneficial ownership. Mr. Garrett Gruener is a managing director of Alta BioPharma Management, LLC (which is the general partner of Alta BioPharma Partners, L.P.), a managing director of Alta/Chase Management, LLC (which is the managing member of The Medicines Company Chase Partners (Alta Bio), LLC) and a member of Alta Embarcadero BioPharma Partners, LLC. Thus he shares voting and dispositive powers over the 341,844 shares of Common Stock and the Warrants for 178,987 shares of Common Stock beneficially owed by Alta BioPharma Partners, L.P.; the 195,226 shares of Common Stock and the Warrants for 102,218 shares of Common Stock beneficially owned by The Medicines Company Chase Partners (Alta Bio), LLC; and the 12,885 shares of Common Stock and the Warrants for 6,746 shares of Common Stock beneficially owned by Alta Embarcadero BioPharma Partners, LLC. Mr. Gruener disclaims beneficial ownership of the shares held by the aforementioned funds except to the extent of his proportionate pecuniary interests therein. On April 2, 2002, Mr. Gruener received 13,742 shares of Common Stock, which was his proportionate pecuniary interest in the stock distributions for Alta Embarcadero BioPharma Partners, LLC, Alta BioPharma Management, LLC and Alta/Chase BioPharma Management, LLC. Mr. Daniel Janney is a managing director of Alta BioPharma Management, LLC (which is the general partner of Alta BioPharma Partners, L.P.), and a managing director of Alta/Chase Management, LLC (which is the managing member of The Medicines Company Chase Partners (Alta Bio), LLC). Thus he shares voting and dispositive powers over the 341,844 shares of Common Stock and the Warrants for 178,987 shares of Common Stock beneficially owed by Alta BioPharma Partners, L.P., and the 195,226 shares of Common Stock and the Warrants for 102,218 shares of Common Stock beneficially owned by The Medicines Company Chase Partners (Alta Bio), LLC. Mr. Janney disclaims beneficial ownership of the shares held by the aforementioned funds except to the extent of his proportionate pecuniary interests therein. On April 2, 2002, Mr. Janney received 18,070 shares of Common Stock, which was his proportionate pecuniary interest in the stock distributions for Alta BioPharma Management, LLC and Alta/Chase BioPharma Management, LLC. Dr. Alix Marduel is a managing director of Alta BioPharma Management, LLC (which is the general partner of Alta BioPharma Partners, L.P.), and a managing director of Alta/Chase Management, LLC (which is the managing member of The Medicines Company Chase Partners (Alta Bio), LLC). Thus she shares voting and dispositive powers over the 341,844 shares of Common Stock and the Warrants for 178,987 shares of Common Stock beneficially owed by Alta BioPharma Partners, L.P., and the 195,226 shares of Common Stock and the Warrants for 102,218 shares of Common Stock beneficially owned by The Medicines Company Chase Partners (Alta Bio), LLC. Dr. Marduel disclaims beneficial ownership of the shares held by the aforementioned funds except to the extent of her proportionate pecuniary interests Page 3 of 3 of Attachment A therein. On April 2, 2002, Dr. Marduel received 18,070 shares of Common Stock, which was her proportionate pecuniary interest in the stock distributions for Alta BioPharma Management, LLC and Alta/Chase BioPharma Management, LLC. Mr. Guy Nohra is a managing director of Alta BioPharma Management, LLC (which is the general partner of Alta BioPharma Partners, L.P.), and a managing director of Alta/Chase Management, LLC (which is the managing member of The Medicines Company Chase Partners (Alta Bio), LLC). Thus he shares voting and dispositive powers over the 341,844 shares of Common Stock and the Warrants for 178,987 shares of Common Stock beneficially owed by Alta BioPharma Partners, L.P., and the 195,226 shares of Common Stock and the Warrants for 102,218 shares of Common Stock beneficially owned by The Medicines Company Chase Partners (Alta Bio), LLC. Mr. Nohra disclaims beneficial ownership of the shares held by the aforementioned funds except to the extent of his proportionate pecuniary interests therein. On April 2, 2002, Mr. Nohra received 13,251 shares of Common Stock, which was his proportionate pecuniary interest in the stock distributions for Alta BioPharma Management, LLC and Alta/Chase BioPharma Management, LLC. Alta Partners is a venture capital firm with an office in San Francisco. Alta Partners is California Corporation. Alta BioPharma Partners, L.P. is a Delaware Limited Partnership, The Medicines Company Chase Partners (Alta Bio), LLC is a Delaware Limited Liability Company, and Alta Embarcadero BioPharma Partners, LLC is a California Limited Liability Company. -----END PRIVACY-ENHANCED MESSAGE-----