X0306 4 2015-12-03 0 0001059790 POZEN INC /NC POZN 0001135011 PLACHETKA JOHN R C/O POZEN INC. 1414 RALEIGH ROAD, SUITE 400 CHAPEL HILL NC 27517 0 0 1 0 Common Stock 506799 D Common Stock 2015-12-03 4 S 0 23479 8.136 D 1232623 I By Trust Common Stock 218910 I By Trust Common Stock 1157808 I By Silver Hill Investments, LLC Common Stock 22631 I By Trust Stock option exercise and open market sales pursuant to a 10b5-1 trading plan adopted by the Reporting Person in accordance with rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The price in column 4 is a weighted average price. The prices actually received by the reporting person in this transaction range from $8.07 to $8.175. Beneficially owned by John R. Plachetka, indirectly, through the Revocable Declaration Trust u/a 1/31/2000, John R. Plachetka, Trustee. Beneficially owned by John R. Plachetka, indirectly, through the Revocable Declaration Trust u/a 1/31/2000, Clare A. Plachetka, Trustee. Beneficially owned by John R. Plachetka, indirectly, as manager of Silver Hill Investments, LLC. Silver Hill Investments LLC is 50% owned by the Family Trust under the John R. Plachetka Irrevocable Trust dated 4/20/2000, Wachovia Bank N.A. and Clare A. Plachetka, Trustees (the "Family Trust"); 40% owned by the Revocable Declaration of Trust u/a 1/31/2000, John R. Plachetka, Trustee; and 10% owned by the Revocable Declaration of Trust u/a 1/31/2000, Clare A. Plachetka, Trustee. Beneficially owned by John R. Plachetka, indirectly, through the Family Trust. The shares in the Family Trust are held in trust for the benefit of Clare A. Plachetka and John R. and Clare A. Plachetka's children. /s/ John E. Barnhardt, Attorney-in-fact 2015-12-07