X0306 4 2015-11-19 0 0001059790 POZEN INC /NC POZN 0001135011 PLACHETKA JOHN R C/O POZEN INC. 1414 RALEIGH ROAD, SUITE 400 CHAPEL HILL NC 27517 0 0 1 0 Common Stock 46782 D Common Stock 2015-11-19 5 G 0 E 148000 0 D 1256102 I By Trust Common Stock 2015-11-19 5 G 0 E 3000 0 D 218910 I By Trust Common Stock 1157808 I By Silver Hill Investments, LLC Common Stock 22631 I By Trust Shares underlying restricted stock units. Beneficially owned by John R. Plachetka, indirectly, through the Revocable Declaration Trust u/a 1/31/2000, John R. Plachetka, Trustee. Beneficially owned by John R. Plachetka, indirectly, through the Revocable Declaration Trust u/a 1/31/2000, Clare A. Plachetka, Trustee. Beneficially owned by John R. Plachetka, indirectly, as manager of Silver Hill Investments, LLC. Silver Hill Investments LLC is 50% owned by the Family Trust under the John R. Plachetka Irrevocable Trust dated 4/20/2000, Wachovia Bank N.A. and Clare A. Plachetka, Trustees (the "Family Trust"); 40% owned by the Revocable Declaration of Trust u/a 1/31/2000, John R. Plachetka, Trustee; and 10% owned by the Revocable Declaration of Trust u/a 1/31/2000, Clare A. Plachetka, Trustee. Beneficially owned by John R. Plachetka, indirectly, through the Family Trust. The shares in the Family Trust are held in trust for the benefit of Clare A. Plachetka and John R. and Clare A. Plachetka's children. /s/ John E. Barnhardt, Attorney-in-fact 2015-11-19