The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | |||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | ||||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | (to the nearest dollar) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 4D MOLECULAR THERAPEUTICS IN | COM | 35104E100 | 51,014,367 | 4,007,413 | SH | DFND | 1 | 0 | 4,007,413 | 0 | ||
| 89BIO INC | COM | 282559103 | 28,504,618 | 1,846,154 | SH | DFND | 1 | 0 | 1,846,154 | 0 | ||
| AC IMMUNE SA | SHS | H00263105 | 21,170,880 | 7,428,379 | SH | DFND | 1 | 0 | 7,428,379 | 0 | ||
| ACLARIS THERAPEUTICS INC | COM | 00461U105 | 48,393,442 | 7,064,736 | SH | DFND | 1 | 0 | 7,064,736 | 0 | ||
| ALLAKOS INC | COM | 01671P100 | 19,413,987 | 8,552,417 | SH | DFND | 1 | 0 | 8,552,417 | 0 | ||
| AN2 THERAPEUTICS INC | COM | 037326105 | 25,148,525 | 1,563,963 | SH | DFND | 1 | 0 | 1,563,963 | 0 | ||
| ASLAN PHARMACEUTICALS LTD | SPON ADS NEW | 04522R200 | 1,942,498 | 1,049,999 | SH | DFND | 1 | 0 | 1,049,999 | 0 | ||
| AXSOME THERAPEUTICS INC | COM | 05464T104 | 148,942,579 | 2,131,100 | SH | DFND | 1 | 0 | 2,131,100 | 0 | ||
| BIONOMICS LIMITED | ADS | 09063M205 | 127,904 | 47,372 | SH | DFND | 1 | 0 | 47,372 | 0 | ||
| CALLIDITAS THERAPEUTICS AB | SPONSERED ADS | 13124Q106 | 13,695,000 | 750,000 | SH | DFND | 1 | 0 | 750,000 | 0 | ||
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 | 58,896,759 | 9,103,054 | SH | DFND | 1 | 0 | 9,103,054 | 0 | ||
| CIDARA THERAPEUTICS INC | COM | 171757107 | 6,464,554 | 6,861,127 | SH | DFND | 1 | 0 | 6,861,127 | 0 | ||
| CORVUS PHARMACEUTICALS INC | COM | 221015100 | 2,001,583 | 1,370,947 | SH | DFND | 1 | 0 | 1,370,947 | 0 | ||
| CULLINAN ONCOLOGY INC | COM | 230031106 | 28,930,144 | 3,196,701 | SH | DFND | 1 | 0 | 3,196,701 | 0 | ||
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 8,508,583 | 6,595,801 | SH | DFND | 1 | 0 | 6,595,801 | 0 | ||
| DELCATH SYS INC | COM NEW | 24661P807 | 3,953,403 | 976,149 | SH | DFND | 1 | 0 | 976,149 | 0 | ||
| ELEDON PHARMACEUTICALS INC | COM | 28617K101 | 5,927,593 | 4,326,710 | SH | DFND | 1 | 0 | 4,326,710 | 0 | ||
| ELEVATION ONCOLOGY INC | COM | 28623U101 | 1,532,064 | 2,312,200 | SH | DFND | 1 | 0 | 2,312,200 | 0 | ||
| ESSA PHARMA INC | COM NEW | 29668H708 | 27,033,264 | 8,748,629 | SH | DFND | 1 | 0 | 8,748,629 | 0 | ||
| FORTE BIOSCIENCES INC | COM | 34962G109 | 1,974,154 | 2,982,105 | SH | DFND | 1 | 0 | 2,982,105 | 0 | ||
| GALAPAGOS NV | SPON ADR | 36315X101 | 66,167,016 | 1,915,109 | SH | DFND | 1 | 0 | 1,915,109 | 0 | ||
| GH RESEARCH PLC | ORDINARY SHARES | G3855L106 | 93,215,338 | 9,275,158 | SH | DFND | 1 | 0 | 9,275,158 | 0 | ||
| GLYCOMIMETICS INC | COM | 38000Q102 | 14,316,393 | 9,544,262 | SH | DFND | 1 | 0 | 9,544,262 | 0 | ||
| IDEAYA BIOSCIENCES INC | COM | 45166A102 | 142,548,533 | 5,283,489 | SH | DFND | 1 | 0 | 5,283,489 | 0 | ||
| IKENA ONCOLOGY INC | COM | 45175G108 | 13,722,480 | 3,169,164 | SH | DFND | 1 | 0 | 3,169,164 | 0 | ||
| IMMUNIC INC | COM | 4525EP101 | 1,689,655 | 1,149,425 | SH | DFND | 1 | 0 | 1,149,425 | 0 | ||
| IMMUNOVANT INC | COM | 45258J102 | 11,517,000 | 300,000 | SH | DFND | 1 | 0 | 300,000 | 0 | ||
| INVENTIVA SA | ADS | 46124U107 | 2,881,368 | 686,040 | SH | DFND | 1 | 0 | 686,040 | 0 | ||
| IONIS PHARMACEUTICALS INC | COM | 462222100 | 181,649,246 | 4,004,613 | SH | DFND | 1 | 0 | 4,004,613 | 0 | ||
| ITEOS THERAPEUTICS INC | COM | 46565G104 | 13,791,262 | 1,259,476 | SH | DFND | 1 | 0 | 1,259,476 | 0 | ||
| JANUX THERAPEUTICS INC | COM | 47103J105 | 46,164,565 | 4,579,818 | SH | DFND | 1 | 0 | 4,579,818 | 0 | ||
| JASPER THERAPEUTICS INC | COM | 471871103 | 6,930,000 | 9,900,000 | SH | DFND | 1 | 0 | 9,900,000 | 0 | ||
| KRONOS BIO INC | COM | 50107A104 | 3,776,556 | 2,905,043 | SH | DFND | 1 | 0 | 2,905,043 | 0 | ||
| KURA ONCOLOGY INC | COM | 50127T109 | 61,386,565 | 6,730,983 | SH | DFND | 1 | 0 | 6,730,983 | 0 | ||
| KYMERA THERAPEUTICS INC | COM | 501575104 | 65,872,156 | 4,739,004 | SH | DFND | 1 | 0 | 4,739,004 | 0 | ||
| LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 21,794,912 | 19,995,332 | SH | DFND | 1 | 0 | 19,995,332 | 0 | ||
| MERUS N V | COM | N5749R100 | 64,902,064 | 2,752,420 | SH | DFND | 1 | 0 | 2,752,420 | 0 | ||
| MIRUM PHARMACEUTICALS INC | COM | 604749101 | 138,092,758 | 4,370,024 | SH | DFND | 1 | 0 | 4,370,024 | 0 | ||
| MOLECULAR PARTNERS AG | ADS | 60853G106 | 1,768,452 | 443,221 | SH | DFND | 1 | 0 | 443,221 | 0 | ||
| MOLECULAR TEMPLATES INC | COM NEW | 608550208 | 3,362,480 | 532,038 | SH | DFND | 1 | 0 | 532,038 | 0 | ||
| MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 | 1,239,823,188 | 21,751,284 | SH | DFND | 1 | 0 | 21,751,284 | 0 | ||
| NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | N62509109 | 14,078,019 | 1,521,948 | SH | DFND | 1 | 0 | 1,521,948 | 0 | ||
| NLS PHARMACEUTICS LTD | SHS | H57830103 | 3,970,689 | 5,747,126 | SH | DFND | 1 | 0 | 5,747,126 | 0 | ||
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 | 112,828,279 | 9,135,893 | SH | DFND | 1 | 0 | 9,135,893 | 0 | ||
| OVID THERAPEUTICS INC | COM | 690469101 | 26,308,036 | 6,851,051 | SH | DFND | 1 | 0 | 6,851,051 | 0 | ||
| PIERIS PHARMACEUTICALS INC | COM | 720795103 | 6,141,739 | 20,609,863 | SH | DFND | 1 | 0 | 20,609,863 | 0 | ||
| POINT BIOPHARMA GLOBAL INC | COM | 730541109 | 70,460,199 | 10,563,748 | SH | DFND | 1 | 0 | 10,563,748 | 0 | ||
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 95,824,065 | 5,744,848 | SH | DFND | 1 | 0 | 5,744,848 | 0 | ||
| RAIN ONCOLOGY INC | COM | 75082Q105 | 3,039,335 | 3,526,729 | SH | DFND | 1 | 0 | 3,526,729 | 0 | ||
| RELAY THERAPEUTICS INC | COM | 75943R102 | 19,896,420 | 2,365,805 | SH | DFND | 1 | 0 | 2,365,805 | 0 | ||
| REPARE THERAPEUTICS INC | COM | 760273102 | 100,167,215 | 8,291,988 | SH | DFND | 1 | 0 | 8,291,988 | 0 | ||
| REPLIMUNE GROUP INC | COM | 76029N106 | 36,667,346 | 2,143,036 | SH | DFND | 1 | 0 | 2,143,036 | 0 | ||
| REVOLUTION MEDICINES INC | COM | 76155X100 | 110,199,948 | 3,981,212 | SH | DFND | 1 | 0 | 3,981,212 | 0 | ||
| REZOLUTE INC | COM NEW | 76200L309 | 251,876 | 190,815 | SH | DFND | 1 | 0 | 190,815 | 0 | ||
| ROIVANT SCIENCES LTD | SHS | G76279101 | 32,031,337 | 2,742,409 | SH | DFND | 1 | 0 | 2,742,409 | 0 | ||
| SILENCE THERAPEUTICS PLC | ADS | 82686Q101 | 14,827,729 | 1,508,416 | SH | DFND | 1 | 0 | 1,508,416 | 0 | ||
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 | 88,235,000 | 1,750,000 | SH | DFND | 1 | 0 | 1,750,000 | 0 | ||
| SUTRO BIOPHARMA INC | COM | 869367102 | 11,617,373 | 3,347,946 | SH | DFND | 1 | 0 | 3,347,946 | 0 | ||
| THIRD HARMONIC BIO INC | COM | 88427A107 | 27,898,312 | 4,365,933 | SH | DFND | 1 | 0 | 4,365,933 | 0 | ||
| TSCAN THERAPEUTICS INC | COM | 89854M101 | 7,653,053 | 2,989,474 | SH | DFND | 1 | 0 | 2,989,474 | 0 | ||
| TYRA BIOSCIENCES INC | COM | 90240B106 | 37,724,223 | 2,739,595 | SH | DFND | 1 | 0 | 2,739,595 | 0 | ||
| UNICYCIVE THERAPEUTICS INC | COM | 90466Y103 | 2,935,664 | 3,413,563 | SH | DFND | 1 | 0 | 3,413,563 | 0 | ||
| VERASTEM INC | COM NEW | 92337C203 | 13,700,830 | 1,685,219 | SH | DFND | 1 | 0 | 1,685,219 | 0 | ||
| VERVE THERAPEUTICS INC | COM | 92539P101 | 8,619,000 | 650,000 | SH | DFND | 1 | 0 | 650,000 | 0 | ||
| VIGIL NEUROSCIENCE INC | COM | 92673K108 | 9,775,482 | 1,813,633 | SH | DFND | 1 | 0 | 1,813,633 | 0 | ||
| VIRACTA THERAPEUTICS INC | COM | 92765F108 | 3,759,248 | 3,614,662 | SH | DFND | 1 | 0 | 3,614,662 | 0 | ||
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 62,443,045 | 1,827,958 | SH | DFND | 1 | 0 | 1,827,958 | 0 | ||
| XOMA CORP DEL | COM NEW | 98419J206 | 51,199,439 | 3,633,743 | SH | DFND | 1 | 0 | 3,633,743 | 0 | ||
| ZYMEWORKS INC | COM | 98985Y108 | 37,215,800 | 5,870,000 | SH | DFND | 1 | 0 | 5,870,000 | 0 | ||