The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ADURO BIOTECH INC | COM | 00739L101 | 2,072 | 295,965 | SH | DFND | 1 | 0 | 295,965 | 0 | |
| ALBIREO PHARMA INC | COM | 01345P106 | 7,810 | 220,000 | SH | DFND | 1 | 0 | 220,000 | 0 | |
| ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 4,868 | 643,059 | SH | DFND | 1 | 0 | 643,059 | 0 | |
| ANAPTYSBIO INC | COM | 032724106 | 23,817 | 335,265 | SH | DFND | 1 | 0 | 335,265 | 0 | |
| ARCUS BIOSCIENCES INC | COM | 03969F109 | 11,748 | 959,840 | SH | DFND | 1 | 0 | 959,840 | 0 | |
| ARQULE INC | COM | 04269E107 | 41,187 | 7,447,912 | SH | DFND | 1 | 0 | 7,447,912 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 78,399 | 4,672,195 | SH | DFND | 1 | 0 | 4,672,195 | 0 | |
| BIOLINERX LTD | SPONSORED ADR | 09071M106 | 23,521 | 25,995,575 | SH | DFND | 1 | 0 | 25,995,575 | 0 | |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 41,060 | 646,811 | SH | DFND | 1 | 0 | 646,811 | 0 | |
| CHEMOCENTRYX INC | COM | 16383L106 | 92,642 | 7,034,346 | SH | DFND | 1 | 0 | 7,034,346 | 0 | |
| CIDARA THERAPEUTICS INC | COM | 171757107 | 10,039 | 1,930,670 | SH | DFND | 1 | 0 | 1,930,670 | 0 | |
| CONCERT PHARMACEUTICALS INC | COM | 206022105 | 30,582 | 1,817,138 | SH | DFND | 1 | 0 | 1,817,138 | 0 | |
| CONTRAFECT CORP | COM | 212326102 | 7,428 | 3,361,071 | SH | DFND | 1 | 0 | 3,361,071 | 0 | |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 | 20,758 | 1,890,507 | SH | DFND | 1 | 0 | 1,890,507 | 0 | |
| CTI BIOPHARMA CORP | COM NEW | 12648L601 | 34,510 | 6,929,690 | SH | DFND | 1 | 0 | 6,929,690 | 0 | |
| CYTOKINETICS INC | COM NEW | 23282W605 | 46,072 | 5,550,890 | SH | DFND | 1 | 0 | 5,550,890 | 0 | |
| ERYTECH PHARMA | SPONSORED ADR | 29604W108 | 7,213 | 625,000 | SH | DFND | 1 | 0 | 625,000 | 0 | |
| ESSA PHARMA INC | COM NEW | 29668H708 | 2,090 | 552,791 | SH | DFND | 1 | 0 | 552,791 | 0 | |
| FIVE PRIME THERAPEUTICS INC | COM | 33830X104 | 17,862 | 1,129,761 | SH | DFND | 1 | 0 | 1,129,761 | 0 | |
| FORWARD PHARMA A/S | SPONSORED ADR | 34986J105 | 23,129 | 8,503,425 | SH | DFND | 1 | 0 | 8,503,425 | 0 | |
| GALMED PHARMACEUTICALS LTD | SHS | M47238106 | 20,963 | 1,761,567 | SH | DFND | 1 | 0 | 1,761,567 | 0 | |
| GENOCEA BIOSCIENCES INC | COM | 372427104 | 4,505 | 5,265,000 | SH | DFND | 1 | 0 | 5,265,000 | 0 | |
| GTX INC DEL | COM NEW | 40052B207 | 5,912 | 386,134 | SH | DFND | 1 | 0 | 386,134 | 0 | |
| IMMUNE DESIGN CORP | COM | 45252L103 | 18,921 | 4,158,353 | SH | DFND | 1 | 0 | 4,158,353 | 0 | |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 29,094 | 15,232,268 | SH | DFND | 1 | 0 | 15,232,268 | 0 | |
| IONIS PHARMACEUTICALS INC | COM | 462222100 | 23,752 | 570,000 | SH | DFND | 1 | 0 | 570,000 | 0 | |
| IRONWOOD PHARMACEUTICALS INC | COM CL A | 46333X108 | 11,600 | 606,715 | SH | DFND | 1 | 0 | 606,715 | 0 | |
| KURA ONCOLOGY INC | COM | 50127T109 | 37,444 | 2,057,346 | SH | DFND | 1 | 0 | 2,057,346 | 0 | |
| LOXO ONCOLOGY INC | COM | 548862101 | 709 | 4,089 | SH | DFND | 1 | 0 | 4,089 | 0 | |
| MEI PHARMA INC | COM NEW | 55279B202 | 12,136 | 3,080,308 | SH | DFND | 1 | 0 | 3,080,308 | 0 | |
| MERRIMACK PHARMACEUTICALS INC | COM NEW | 590328209 | 5,453 | 1,110,588 | SH | DFND | 1 | 0 | 1,110,588 | 0 | |
| MERUS N V | COM | N5749R100 | 89,103 | 3,914,913 | SH | DFND | 1 | 0 | 3,914,913 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 36,729 | 745,000 | SH | DFND | 1 | 0 | 745,000 | 0 | |
| MOLECULAR TEMPLATES INC | COM | 608550109 | 3,602 | 688,629 | SH | DFND | 1 | 0 | 688,629 | 0 | |
| ONCOMED PHARMACEUTICALS INC | COM | 68234X102 | 9,470 | 4,099,589 | SH | DFND | 1 | 0 | 4,099,589 | 0 | |
| PIERIS PHARMACEUTICALS INC | COM | 720795103 | 27,108 | 5,346,838 | SH | DFND | 1 | 0 | 5,346,838 | 0 | |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 9,529 | 1,417,967 | SH | DFND | 1 | 0 | 1,417,967 | 0 | |
| REGULUS THERAPEUTICS INC | COM | 75915K101 | 9,021 | 13,685,204 | SH | DFND | 1 | 0 | 13,685,204 | 0 | |
| SPERO THERAPEUTICS INC | COM | 84833T103 | 15,388 | 1,048,958 | SH | DFND | 1 | 0 | 1,048,958 | 0 | |
| SPRING BK PHARMACEUTICALS INC | COM | 849431101 | 9,314 | 785,950 | SH | DFND | 1 | 0 | 785,950 | 0 | |
| SUNESIS PHARMACEUTICALS INC | COM PAR | 867328700 | 3,571 | 1,684,636 | SH | DFND | 1 | 0 | 1,684,636 | 0 | |
| SURFACE ONCOLOGY INC | COM | 86877M209 | 5,453 | 334,333 | SH | DFND | 1 | 0 | 334,333 | 0 | |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 8,660 | 1,233,618 | SH | DFND | 1 | 0 | 1,233,618 | 0 | |
| TOCAGEN INC | COM | 888846102 | 4,399 | 471,007 | SH | DFND | 1 | 0 | 471,007 | 0 | |
| VBI VACCINES INC | COM NEW | 91822J103 | 8,525 | 3,100,000 | SH | DFND | 1 | 0 | 3,100,000 | 0 | |
| VERASTEM INC | COM | 92337C104 | 15,427 | 2,242,353 | SH | DFND | 1 | 0 | 2,242,353 | 0 | |
| VICAL INC | COM NEW | 925602203 | 1,532 | 1,332,605 | SH | DFND | 1 | 0 | 1,332,605 | 0 | |
| XENCOR INC | COM | 98401F105 | 32,186 | 869,645 | SH | DFND | 1 | 0 | 869,645 | 0 | |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 6,632 | 720,830 | SH | DFND | 1 | 0 | 720,830 | 0 | |
| XOMA CORP DEL | COM NEW | 98419J206 | 31,378 | 1,502,800 | SH | DFND | 1 | 0 | 1,502,800 | 0 | |
| ZYMEWORKS INC | COM | 98985W102 | 293 | 19,804 | SH | DFND | 1 | 0 | 19,804 | 0 | |