The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
|
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
|
||||||||||||||||
| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ARQULE INC | COM | 04269E107 | 14,777 | 6,809,843 | SH | DFND | 1 | 0 | 6,809,843 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 28,201 | 6,682,711 | SH | DFND | 1 | 0 | 6,682,711 | 0 | |
| ARRAY BIOPHARMA INC | NOTE 3.000% 6/0 | 04269XAA3 | 2,327 | 2,500,000 | PRN | DFND | 1 | 0 | 2,500,000 | 0 | |
| BIOTA PHARMACEUTIALS INC | COM | 090694100 | 681 | 350,776 | SH | DFND | 1 | 0 | 350,776 | 0 | |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 60,015 | 2,278,459 | SH | DFND | 1 | 0 | 2,278,459 | 0 | |
| CALITHERA BIOSCIENCES INC | COM | 13089P101 | 1,286 | 167,900 | SH | DFND | 1 | 0 | 167,900 | 0 | |
| CATALYST BIOSCIENCES INC | COM | 14888D109 | 3,039 | 970,948 | SH | DFND | 1 | 0 | 970,948 | 0 | |
| CHEMOCENTRYX INC | COM | 16383L106 | 54,090 | 6,677,722 | SH | DFND | 1 | 0 | 6,677,722 | 0 | |
| CONCERT PHARMACEUTICALS INC | COM | 206022105 | 42,341 | 2,232,014 | SH | DFND | 1 | 0 | 2,232,014 | 0 | |
| CTI BIOPHARMA CORP | COM | 12648L106 | 53,869 | 43,795,613 | SH | DFND | 1 | 0 | 43,795,613 | 0 | |
| CYTOKINETICS INC | COM NEW | 23282W605 | 30,550 | 2,920,628 | SH | DFND | 1 | 0 | 2,920,628 | 0 | |
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 12,707 | 608,848 | SH | DFND | 1 | 0 | 608,848 | 0 | |
| EXELIXIS INC | NOTE 4.250% 8/1 | 30161QAC8 | 22,187 | 18,842,778 | PRN | DFND | 1 | 0 | 18,842,778 | 0 | |
| FIVE PRIME THERAPEUTICS INC | COM | 33830X104 | 12,450 | 300,000 | SH | DFND | 1 | 0 | 300,000 | 0 | |
| FORWARD PHARMA A/S | SPONSORED ADR | 34986J105 | 27,384 | 1,441,287 | SH | DFND | 1 | 0 | 1,441,287 | 0 | |
| GLOBEIMMUNE INC | COM | 37957B100 | 2,539 | 657,653 | SH | DFND | 1 | 0 | 657,653 | 0 | |
| GTX INC DEL | COM | 40052B108 | 7,814 | 11,163,136 | SH | DFND | 1 | 0 | 11,163,136 | 0 | |
| IRONWOOD PHARMACEUTICALS INC | COM CL A | 46333X108 | 34,028 | 2,935,975 | SH | DFND | 1 | 0 | 2,935,975 | 0 | |
| LOXO ONCOLOGY INC | COM | 548862101 | 20,230 | 711,067 | SH | DFND | 1 | 0 | 711,067 | 0 | |
| MAST THERAPEUTICS INC | COM | 576314108 | 1,554 | 3,696,961 | SH | DFND | 1 | 0 | 3,696,961 | 0 | |
| NEPHROGENEX INC | COM | 640667101 | 627 | 392,156 | SH | DFND | 1 | 0 | 392,156 | 0 | |
| NIVALIS THERAPEUTICS INC | COM | 65481J109 | 9,249 | 1,195,013 | SH | DFND | 1 | 0 | 1,195,013 | 0 | |
| ONCOMED PHARMACEUTICALS INC | COM | 68234X102 | 22,347 | 991,433 | SH | DFND | 1 | 0 | 991,433 | 0 | |
| ONCOTHYREON INC | COM | 682324108 | 41,735 | 18,799,368 | SH | DFND | 1 | 0 | 18,799,368 | 0 | |
| PAIN THERAPEUTICS INC | COM | 69562K100 | 3,242 | 1,852,353 | SH | DFND | 1 | 0 | 1,852,353 | 0 | |
| QLT INC | COM | 746927102 | 14,269 | 5,364,385 | SH | DFND | 1 | 0 | 5,364,385 | 0 | |
| SUNESIS PHARMACEUTICALS INC | COM NEW | 867328601 | 4,288 | 4,777,381 | SH | DFND | 1 | 0 | 4,777,381 | 0 | |
| TOBIRA THERAPEUTICS INC | COM | 88883P101 | 12,597 | 1,253,401 | SH | DFND | 1 | 0 | 1,253,401 | 0 | |
| VITAE PHARMACEUTICALS INC | COM | 92847N103 | 37,310 | 2,061,325 | SH | DFND | 1 | 0 | 2,061,325 | 0 | |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 9,050 | 1,125,572 | SH | DFND | 1 | 0 | 1,125,572 | 0 | |