The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIVAX SA SPONSORED ADS 00370M103   51,855,695 465,700 SH   DFND   124,000 0 341,700
ADC THERAPEUTICS SA SHS H0036K147   4,942,598 1,318,026 SH   DFND   586,721 0 731,305
ADICET BIO INC COM NEW 007002207   7,000,299 1,027,944 SH   SOLE   1,027,944 0 0
ALIGNMENT HEALTHCARE INC COM 01625V104   13,937,420 791,000 SH   SOLE   0 0 791,000
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   39,373,530 119,000 SH   SOLE   0 0 119,000
ALTO NEUROSCIENCE INC COM SHS 02157Q109   3,765,400 167,500 SH   SOLE   0 0 167,500
ALUMIS INC COM 022307102   12,076,031 548,163 SH   SOLE   548,163 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105   5,746,843 2,866,256 SH   DFND   1,338,056 0 1,528,200
AMGEN INC COM 031162100   14,038,815 39,900 SH   SOLE   0 0 39,900
ARGENX SE SPONSORED ADR 04016X101   99,971,225 136,900 SH   DFND   27,700 0 109,200
ARRIVENT BIOPHARMA INC COM 04272N102   69,840,457 3,027,328 SH   SOLE   3,027,328 0 0
ARS PHARMACEUTICALS INC COM 82835W108   66,556,735 8,288,510 SH   SOLE   8,288,510 0 0
ARTIVION INC COM 228903100   5,529,620 151,000 SH   DFND   94,400 0 56,600
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101   41,623,599 181,977 SH   DFND   32,336 0 149,641
ASTRAZENECA PLC ORD G0593M107   132,176,844 670,200 SH   SOLE   0 0 670,200
ATAIBECKLEY INC COM SHS 04650F101   1,228,380 347,000 SH   SOLE   347,000 0 0
AVALO THERAPEUTICS INC COM NEW 05338F306   7,094,213 475,165 SH   SOLE   475,165 0 0
AVITA MEDICAL INC COM 05380C102   2,016,112 544,895 SH   SOLE   544,895 0 0
AVITA MEDICAL INC COM 05380C102   40,500,000 40,500,000 PRN   SOLE   40,500,000 0 0
AVITA MEDICAL INC COM 05380C102   154,442,197 40,966,100 SH Call SOLE   40,966,100 0 0
AXSOME THERAPEUTICS INC. COM 05464T104   36,156,927 213,921 SH   DFND   41,734 0 172,187
BICARA THERAPEUTICS INC COM 055477103   13,272,597 667,300 SH   DFND   264,100 0 403,200
BIOAGE LABS INC COM 09077V100   12,449,574 711,811 SH   SOLE   711,811 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103   13,567,904 1,425,200 SH   DFND   557,200 0 868,000
BIOGEN INC COM 09062X103   11,293,128 61,600 SH   SOLE   0 0 61,600
BOSTON SCIENTIFIC CORP COM 101137107   149,476,775 2,382,100 SH   SOLE   0 0 2,382,100
BRIGHT MINDS BIOSCIENCES INC COM NEW 10919W405   2,918,800 40,000 SH   SOLE   0 0 40,000
BRIGHTSPRING HEALTH SVCS INC COM 10950A106   21,211,258 497,800 SH   SOLE   0 0 497,800
BRISTOL-MYERS SQUIBB CO COM 110122108   56,101,250 925,000 SH   SOLE   0 0 925,000
C4 THERAPEUTICS INC COM STK 12529R107   2,252,208 856,353 SH   DFND   395,996 0 460,357
CARIS LIFE SCIENCES INC COM 142152107   50,185,781 2,806,811 SH   DFND   437,650 0 2,369,161
CARLSMED INC COM 14280C105   11,336,030 1,252,600 SH   DFND   204,306 0 1,048,294
CG ONCOLOGY INC COM 156944100   64,178,711 948,267 SH   DFND   194,000 0 754,267
COGENT BIOSCIENCES INC COM 19240Q201   12,397,629 322,100 SH   DFND   80,500 0 241,600
COGENT BIOSCIENCES INC NOTE 1.625%11/1 19240QAA0   1,220,000 1,000,000 PRN   SOLE   0 0 1,000,000
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101   6,363,072 1,150,646 SH   DFND   519,146 0 631,500
COMPASS THERAPEUTICS INC COM 20454B104   80,513,768 15,219,994 SH   SOLE   15,219,994 0 0
CORBUS PHARMACEUTICALS HLDGS COM NEW 21833P301   16,313,125 1,737,287 SH   DFND   758,687 0 978,600
CORVUS PHARMACEUTICALS INC COM 221015100   104,824,038 7,165,006 SH   SOLE   7,165,006 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107   36,283,680 999,000 SH   SOLE   999,000 0 0
CULLINAN THERAPEUTICS INC COM 230031106   3,453,115 243,006 SH   SOLE   243,006 0 0
CYBIN INC COM NEW 23256X407   18,397,646 3,832,843 SH   DFND   1,417,900 0 2,414,943
DANAHER CORP DEL COM 235851102   50,395,680 265,800 SH   SOLE   0 0 265,800
DEFINIUM THERAPEUTICS INC COM SHS 24477V105   15,195,600 804,000 SH   DFND   500,000 0 304,000
DISC MEDICINE INC COM 254604101   68,259,147 1,067,550 SH   SOLE   1,067,550 0 0
DYNE THERAPEUTICS INC COM 26818M108   52,901,237 2,917,884 SH   DFND   976,300 0 1,941,584
EDGEWISE THERAPEUTICS INC COM 28036F105   488,832,498 15,518,492 SH   DFND   15,252,867 0 265,625
EDWARDS LIFESCIENCES CORP COM 28176E108   98,546,448 1,230,600 SH   SOLE   0 0 1,230,600
ELEVANCE HEALTH INC FORMERLY COM 036752103   33,578,425 114,700 SH   SOLE   0 0 114,700
ELI LILLY & CO COM 532457108   217,801,536 236,800 SH   SOLE   0 0 236,800
ENLIVEN THERAPEUTICS INC COM 29337E102   312,013,890 7,959,538 SH   DFND   7,918,163 0 41,375
ESPERION THERAPEUTICS INC NE COM 29664W105   28,962,622 10,570,300 SH   DFND   4,741,100 0 5,829,200
EYEPOINT INC COM NEW 30233G209   13,781,305 1,069,147 SH   DFND   504,920 0 564,227
FORTE BIOSCIENCES INC COM NEW 34962G208   31,001,135 1,196,955 SH   DFND   884,230 0 312,725
GILEAD SCIENCES INC COM 375558103   8,306,452 59,600 SH   SOLE   0 0 59,600
GUARDANT HEALTH INC COM 40131M109   40,199,424 435,200 SH   DFND   98,400 0 336,800
HERON THERAPEUTICS INC COM 427746102   7,854,534 9,816,940 SH   DFND   5,074,923 0 4,742,017
IMAGENEBIO INC COM 45175G207   1,892,780 378,556 SH   DFND   295,469 0 83,087
IMAGENEBIO INC NONVOTING 000000000   2,653,565 530,713 SH   DFND   478,284 0 52,429
INSPIREMD INC COM 45779A846   5,107,450 3,133,405 SH   SOLE   3,133,405 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602   96,208,613 208,700 SH   SOLE   0 0 208,700
JADE BIOSCIENCES INC COM NEW 008064206   2,599,405 185,011 SH   SOLE   185,011 0 0
JANUX THERAPEUTICS INC COM 47103J105   13,672,040 983,600 SH   DFND   524,700 0 458,900
KALVISTA PHARMACEUTICALS INC COM 483497103   1,900,272 94,400 SH   SOLE   0 0 94,400
KEROS THERAPEUTICS INC COM 492327101   8,381,071 759,155 SH   SOLE   759,155 0 0
KINIKSA PHARMACEUTICALS INTL ORD SHS CL A G52694109   8,695,842 180,599 SH   SOLE   0 0 180,599
KRYSTAL BIOTECH INC COM 501147102   17,849,912 69,100 SH   DFND   25,100 0 44,000
LEXEO THERAPEUTICS INC COM 52886X107   20,678,063 3,602,450 SH   DFND   3,203,050 0 399,400
LIFESTANCE HEALTH GROUP INC COM 53228F101   3,185,000 500,000 SH   DFND   312,400 0 187,600
MBX BIOSCIENCES INC COM 55287L101   108,590,927 3,637,887 SH   SOLE   3,637,887 0 0
MDXHEALTH SA SHS NEW B5950S113   285,903,800 124,306,000 SH Call SOLE   124,306,000 0 0
MERCK & CO INC COM 58933Y105   79,800,386 663,400 SH   SOLE   0 0 663,400
MINERALYS THERAPEUTICS INC COM 603170101   55,613,061 2,052,900 SH   DFND   534,100 0 1,518,800
MYRIAD GENETICS INC COM 62855J104   122,875,000 125,000,000 PRN   SOLE   125,000,000 0 0
NATERA INC COM 632307104   52,397,380 262,000 SH   DFND   41,000 0 221,000
NEKTAR THERAPEUTICS COM NEW 640268306   19,786,250 275,000 SH   DFND   130,100 0 144,900
NEUROPACE INC COM 641288105   27,569,330 2,096,527 SH   SOLE   2,096,527 0 0
ORIC PHARMACEUTICALS INC COM 68622P109   34,132,080 2,693,929 SH   DFND   1,075,921 0 1,618,008
PALISADE BIO INC COM 696389402   4,082,750 2,333,000 SH   SOLE   0 0 2,333,000
PALVELLA THERAPEUTICS INC NE COM 697947109   16,777,890 134,600 SH   DFND   46,500 0 88,100
PALVELLA THERAPEUTICS INC NE COM 697947109   6,232,500 50,000 SH Call DFND   31,300 0 18,700
PFIZER INC COM 717081103   54,657,720 1,946,500 SH   SOLE   0 0 1,946,500
PHARVARIS N V COM N69605108   5,802,550 205,400 SH   SOLE   0 0 205,400
PRAXIS PRECISION MEDICINES I COM NEW 74006W207   55,577,775 172,500 SH   DFND   33,600 0 138,900
PRELUDE THERAPEUTICS INC COM 74065P101   37,309,656 10,909,256 SH   DFND   10,119,756 0 789,500
PRELUDE THERAPEUTICS INC NONVOTING 000000000   19,426,236 5,680,186 SH   DFND   5,596,886 0 83,300
PROTAGONIST THERAPEUTICS INC COM 74366E102   4,437,340 42,100 SH   SOLE   0 0 42,100
PTC THERAPEUTICS INC COM 69366J200   3,345,183 49,100 SH   SOLE   0 0 49,100
Q32 BIO INC COM 746964105   14,464,177 2,252,987 SH   SOLE   2,252,987 0 0
QIAGEN NV ORD SHARES N72482156   10,010,000 250,000 SH Call DFND   157,700 0 92,300
REGENERON PHARMACEUTICALS COM 75886F107   11,357,808 14,700 SH   SOLE   0 0 14,700
RELMADA THERAPEUTICS INC COM 75955J402   32,822,413 4,715,864 SH   DFND   2,699,587 0 2,016,277
REVOLUTION MEDICINES INC COM 76155X100   5,057,000 52,000 SH   SOLE   0 0 52,000
RHYTHM PHARMACEUTICALS INC COM 76243J105   27,317,277 314,100 SH   DFND   88,800 0 225,300
SAVARA INC COM 805111101   3,467,100 635,000 SH   SOLE   0 0 635,000
SHATTUCK LABS INC COM 82024L103   40,548,397 6,306,127 SH   SOLE   6,306,127 0 0
SINOVAC BIOTECH LTD SHS P8696W104   184,466,170 2,718,735 SH   SOLE   0 0 2,718,735
SIONNA THERAPEUTICS INC COM 829401108   141,545,843 3,530,702 SH   SOLE   3,530,702 0 0
SOLENO THERAPEUTICS INC COM 834203309   3,348,000 100,000 SH Call DFND   62,400 0 37,600
STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106   71,114,425 1,475,403 SH   DFND   351,803 0 1,123,600
STRYKER CORPORATION COM 863667101   59,967,675 182,500 SH   SOLE   0 0 182,500
SUTRO BIOPHARMA INC COM SHS 869367201   19,956,497 801,144 SH   SOLE   801,144 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   22,479,328 962,300 SH   DFND   351,000 0 611,300
TECTONIC THERAPEUTIC INC COM 878972108   7,004,206 226,600 SH   DFND   149,300 0 77,300
THERMO FISHER SCIENTIFIC INC COM 883556102   22,856,145 46,500 SH   SOLE   0 0 46,500
TRAWS PHARMA INC COM NEW 68232V884   1,108,122 605,531 SH   SOLE   605,531 0 0
TREVI THERAPEUTICS INC COM 89532M101   29,280,992 2,454,400 SH   DFND   1,079,400 0 1,375,000
UNIQURE NV SHS N90064101   34,926,036 2,136,149 SH   DFND   657,349 0 1,478,800
UPSTREAM BIO INC COM 91678A107   51,242,301 5,693,589 SH   SOLE   5,693,589 0 0
UROGEN PHARMA LTD COM M96088105   15,741,256 875,487 SH   DFND   194,573 0 680,914
VERA THERAPEUTICS INC CL A 92337R101   14,868,847 369,596 SH   DFND   185,296 0 184,300
VISTAGEN THERAPEUTICS INC COM 92840H400   1,748,790 3,060,000 SH   DFND   1,420,300 0 1,639,700
WHITEHAWK THERAPEUTICS INC COM 00032Q104   14,372,700 4,166,000 SH   SOLE   4,166,000 0 0
XENON PHARMACEUTICALS INC COM 98420N105   61,637,314 1,059,971 SH   DFND   266,971 0 793,000