ABIVAX SA SPONSORED ADS 00370M103 51855695 465700 SH DFND 124000 0 341700 ADC THERAPEUTICS SA SHS H0036K147 4942598 1318026 SH DFND 586721 0 731305 ADICET BIO INC COM NEW 007002207 7000299 1027944 SH SOLE 1027944 0 0 ALIGNMENT HEALTHCARE INC COM 01625V104 13937420 791000 SH SOLE 0 0 791000 ALNYLAM PHARMACEUTICALS INC COM 02043Q107 39373530 119000 SH SOLE 0 0 119000 ALTO NEUROSCIENCE INC COM SHS 02157Q109 3765400 167500 SH SOLE 0 0 167500 ALUMIS INC COM 022307102 12076031 548163 SH SOLE 548163 0 0 ALX ONCOLOGY HLDGS INC COM 00166B105 5746843 2866256 SH DFND 1338056 0 1528200 AMGEN INC COM 031162100 14038815 39900 SH SOLE 0 0 39900 ARGENX SE SPONSORED ADR 04016X101 99971225 136900 SH DFND 27700 0 109200 ARRIVENT BIOPHARMA INC COM 04272N102 69840457 3027328 SH SOLE 3027328 0 0 ARS PHARMACEUTICALS INC COM 82835W108 66556735 8288510 SH SOLE 8288510 0 0 ARTIVION INC COM 228903100 5529620 151000 SH DFND 94400 0 56600 ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 41623599 181977 SH DFND 32336 0 149641 ASTRAZENECA PLC ORD G0593M107 132176844 670200 SH SOLE 0 0 670200 ATAIBECKLEY INC COM SHS 04650F101 1228380 347000 SH SOLE 347000 0 0 AVALO THERAPEUTICS INC COM NEW 05338F306 7094213 475165 SH SOLE 475165 0 0 AVITA MEDICAL INC COM 05380C102 2016112 544895 SH SOLE 544895 0 0 AVITA MEDICAL INC COM 05380C102 40500000 40500000 PRN SOLE 40500000 0 0 AVITA MEDICAL INC COM 05380C102 154442197 40966100 SH Call SOLE 40966100 0 0 AXSOME THERAPEUTICS INC. 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80500 0 241600 COGENT BIOSCIENCES INC NOTE 1.625%11/1 19240QAA0 1220000 1000000 PRN SOLE 0 0 1000000 COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 6363072 1150646 SH DFND 519146 0 631500 COMPASS THERAPEUTICS INC COM 20454B104 80513768 15219994 SH SOLE 15219994 0 0 CORBUS PHARMACEUTICALS HLDGS COM NEW 21833P301 16313125 1737287 SH DFND 758687 0 978600 CORVUS PHARMACEUTICALS INC COM 221015100 104824038 7165006 SH SOLE 7165006 0 0 CRINETICS PHARMACEUTICALS IN COM 22663K107 36283680 999000 SH SOLE 999000 0 0 CULLINAN THERAPEUTICS INC COM 230031106 3453115 243006 SH SOLE 243006 0 0 CYBIN INC COM NEW 23256X407 18397646 3832843 SH DFND 1417900 0 2414943 DANAHER CORP DEL COM 235851102 50395680 265800 SH SOLE 0 0 265800 DEFINIUM THERAPEUTICS INC COM SHS 24477V105 15195600 804000 SH DFND 500000 0 304000 DISC MEDICINE INC COM 254604101 68259147 1067550 SH SOLE 1067550 0 0 DYNE THERAPEUTICS INC COM 26818M108 52901237 2917884 SH DFND 976300 0 1941584 EDGEWISE THERAPEUTICS INC COM 28036F105 488832498 15518492 SH DFND 15252867 0 265625 EDWARDS LIFESCIENCES CORP COM 28176E108 98546448 1230600 SH SOLE 0 0 1230600 ELEVANCE HEALTH INC FORMERLY COM 036752103 33578425 114700 SH SOLE 0 0 114700 ELI LILLY & CO COM 532457108 217801536 236800 SH SOLE 0 0 236800 ENLIVEN THERAPEUTICS INC COM 29337E102 312013890 7959538 SH DFND 7918163 0 41375 ESPERION THERAPEUTICS INC NE COM 29664W105 28962622 10570300 SH DFND 4741100 0 5829200 EYEPOINT INC COM NEW 30233G209 13781305 1069147 SH DFND 504920 0 564227 FORTE BIOSCIENCES INC COM NEW 34962G208 31001135 1196955 SH DFND 884230 0 312725 GILEAD SCIENCES INC COM 375558103 8306452 59600 SH SOLE 0 0 59600 GUARDANT HEALTH INC COM 40131M109 40199424 435200 SH DFND 98400 0 336800 HERON THERAPEUTICS INC COM 427746102 7854534 9816940 SH DFND 5074923 0 4742017 IMAGENEBIO INC COM 45175G207 1892780 378556 SH DFND 295469 0 83087 IMAGENEBIO INC NONVOTING 000000000 2653565 530713 SH DFND 478284 0 52429 INSPIREMD INC COM 45779A846 5107450 3133405 SH SOLE 3133405 0 0 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1123600 STRYKER CORPORATION COM 863667101 59967675 182500 SH SOLE 0 0 182500 SUTRO BIOPHARMA INC COM SHS 869367201 19956497 801144 SH SOLE 801144 0 0 SYNDAX PHARMACEUTICALS INC COM 87164F105 22479328 962300 SH DFND 351000 0 611300 TECTONIC THERAPEUTIC INC COM 878972108 7004206 226600 SH DFND 149300 0 77300 THERMO FISHER SCIENTIFIC INC COM 883556102 22856145 46500 SH SOLE 0 0 46500 TRAWS PHARMA INC COM NEW 68232V884 1108122 605531 SH SOLE 605531 0 0 TREVI THERAPEUTICS INC COM 89532M101 29280992 2454400 SH DFND 1079400 0 1375000 UNIQURE NV SHS N90064101 34926036 2136149 SH DFND 657349 0 1478800 UPSTREAM BIO INC COM 91678A107 51242301 5693589 SH SOLE 5693589 0 0 UROGEN PHARMA LTD COM M96088105 15741256 875487 SH DFND 194573 0 680914 VERA THERAPEUTICS INC CL A 92337R101 14868847 369596 SH DFND 185296 0 184300 VISTAGEN THERAPEUTICS INC COM 92840H400 1748790 3060000 SH DFND 1420300 0 1639700 WHITEHAWK THERAPEUTICS INC COM 00032Q104 14372700 4166000 SH SOLE 4166000 0 0 XENON PHARMACEUTICALS 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