0001172661-26-002369.txt : 20260515 0001172661-26-002369.hdr.sgml : 20260515 20260515163754 ACCESSION NUMBER: 0001172661-26-002369 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20260331 FILED AS OF DATE: 20260515 DATE AS OF CHANGE: 20260515 EFFECTIVENESS DATE: 20260515 FILER: COMPANY DATA: COMPANY CONFORMED NAME: ORBIMED ADVISORS LLC CENTRAL INDEX KEY: 0001055951 ORGANIZATION NAME: EIN: 133976876 STATE OF INCORPORATION: DE FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-06774 FILM NUMBER: 26988836 BUSINESS ADDRESS: STREET 1: 601 LEXINGTON AVENUE STREET 2: 54TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10022 BUSINESS PHONE: (212) 739-6400 MAIL ADDRESS: STREET 1: 601 LEXINGTON AVENUE STREET 2: 54TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10022 13F-HR 1 primary_doc.xml X0202 13F-HR LIVE false true false 0001055951 XXXXXXXX 03-31-2026 03-31-2026 false ORBIMED ADVISORS LLC

601 Lexington Avenue 54th Floor New York NY 10022

13F HOLDINGS REPORT 028-06774 000118608 801-61046 N Sven H. Borho 212-739-6400 /s/ Sven H. Borho New York NY 05-15-2026 1 114 5045363608 1 0001157524 028-10410 000120188 801-61952 ORBIMED CAPITAL LLC INFORMATION TABLE 2 infotable.xml ABIVAX SA SPONSORED ADS 00370M103 51855695 465700 SH DFND 124000 0 341700 ADC THERAPEUTICS SA SHS H0036K147 4942598 1318026 SH DFND 586721 0 731305 ADICET BIO INC COM NEW 007002207 7000299 1027944 SH SOLE 1027944 0 0 ALIGNMENT HEALTHCARE INC COM 01625V104 13937420 791000 SH SOLE 0 0 791000 ALNYLAM PHARMACEUTICALS INC COM 02043Q107 39373530 119000 SH SOLE 0 0 119000 ALTO NEUROSCIENCE INC COM SHS 02157Q109 3765400 167500 SH SOLE 0 0 167500 ALUMIS INC COM 022307102 12076031 548163 SH SOLE 548163 0 0 ALX ONCOLOGY HLDGS INC COM 00166B105 5746843 2866256 SH DFND 1338056 0 1528200 AMGEN INC COM 031162100 14038815 39900 SH SOLE 0 0 39900 ARGENX SE SPONSORED ADR 04016X101 99971225 136900 SH DFND 27700 0 109200 ARRIVENT BIOPHARMA INC COM 04272N102 69840457 3027328 SH SOLE 3027328 0 0 ARS PHARMACEUTICALS INC COM 82835W108 66556735 8288510 SH SOLE 8288510 0 0 ARTIVION INC COM 228903100 5529620 151000 SH DFND 94400 0 56600 ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 41623599 181977 SH DFND 32336 0 149641 ASTRAZENECA PLC ORD G0593M107 132176844 670200 SH SOLE 0 0 670200 ATAIBECKLEY INC COM SHS 04650F101 1228380 347000 SH SOLE 347000 0 0 AVALO THERAPEUTICS INC COM NEW 05338F306 7094213 475165 SH SOLE 475165 0 0 AVITA MEDICAL INC COM 05380C102 2016112 544895 SH SOLE 544895 0 0 AVITA MEDICAL INC COM 05380C102 40500000 40500000 PRN SOLE 40500000 0 0 AVITA MEDICAL INC COM 05380C102 154442197 40966100 SH Call SOLE 40966100 0 0 AXSOME THERAPEUTICS INC. COM 05464T104 36156927 213921 SH DFND 41734 0 172187 BICARA THERAPEUTICS INC COM 055477103 13272597 667300 SH DFND 264100 0 403200 BIOAGE LABS INC COM 09077V100 12449574 711811 SH SOLE 711811 0 0 BIOCRYST PHARMACEUTICALS INC COM 09058V103 13567904 1425200 SH DFND 557200 0 868000 BIOGEN INC COM 09062X103 11293128 61600 SH SOLE 0 0 61600 BOSTON SCIENTIFIC CORP COM 101137107 149476775 2382100 SH SOLE 0 0 2382100 BRIGHT MINDS BIOSCIENCES INC COM NEW 10919W405 2918800 40000 SH SOLE 0 0 40000 BRIGHTSPRING HEALTH SVCS INC COM 10950A106 21211258 497800 SH SOLE 0 0 497800 BRISTOL-MYERS SQUIBB CO COM 110122108 56101250 925000 SH SOLE 0 0 925000 C4 THERAPEUTICS INC COM STK 12529R107 2252208 856353 SH DFND 395996 0 460357 CARIS LIFE SCIENCES INC COM 142152107 50185781 2806811 SH DFND 437650 0 2369161 CARLSMED INC COM 14280C105 11336030 1252600 SH DFND 204306 0 1048294 CG ONCOLOGY INC COM 156944100 64178711 948267 SH DFND 194000 0 754267 COGENT BIOSCIENCES INC COM 19240Q201 12397629 322100 SH DFND 80500 0 241600 COGENT BIOSCIENCES INC NOTE 1.625%11/1 19240QAA0 1220000 1000000 PRN SOLE 0 0 1000000 COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 6363072 1150646 SH DFND 519146 0 631500 COMPASS THERAPEUTICS INC COM 20454B104 80513768 15219994 SH SOLE 15219994 0 0 CORBUS PHARMACEUTICALS HLDGS COM NEW 21833P301 16313125 1737287 SH DFND 758687 0 978600 CORVUS PHARMACEUTICALS INC COM 221015100 104824038 7165006 SH SOLE 7165006 0 0 CRINETICS PHARMACEUTICALS IN COM 22663K107 36283680 999000 SH SOLE 999000 0 0 CULLINAN THERAPEUTICS INC COM 230031106 3453115 243006 SH SOLE 243006 0 0 CYBIN INC COM NEW 23256X407 18397646 3832843 SH DFND 1417900 0 2414943 DANAHER CORP DEL COM 235851102 50395680 265800 SH SOLE 0 0 265800 DEFINIUM THERAPEUTICS INC COM SHS 24477V105 15195600 804000 SH DFND 500000 0 304000 DISC MEDICINE INC COM 254604101 68259147 1067550 SH SOLE 1067550 0 0 DYNE THERAPEUTICS INC COM 26818M108 52901237 2917884 SH DFND 976300 0 1941584 EDGEWISE THERAPEUTICS INC COM 28036F105 488832498 15518492 SH DFND 15252867 0 265625 EDWARDS LIFESCIENCES CORP COM 28176E108 98546448 1230600 SH SOLE 0 0 1230600 ELEVANCE HEALTH INC FORMERLY COM 036752103 33578425 114700 SH SOLE 0 0 114700 ELI LILLY & CO COM 532457108 217801536 236800 SH SOLE 0 0 236800 ENLIVEN THERAPEUTICS INC COM 29337E102 312013890 7959538 SH DFND 7918163 0 41375 ESPERION THERAPEUTICS INC NE COM 29664W105 28962622 10570300 SH DFND 4741100 0 5829200 EYEPOINT INC COM NEW 30233G209 13781305 1069147 SH DFND 504920 0 564227 FORTE BIOSCIENCES INC COM NEW 34962G208 31001135 1196955 SH DFND 884230 0 312725 GILEAD SCIENCES INC COM 375558103 8306452 59600 SH SOLE 0 0 59600 GUARDANT HEALTH INC COM 40131M109 40199424 435200 SH DFND 98400 0 336800 HERON THERAPEUTICS INC COM 427746102 7854534 9816940 SH DFND 5074923 0 4742017 IMAGENEBIO INC COM 45175G207 1892780 378556 SH DFND 295469 0 83087 IMAGENEBIO INC NONVOTING 000000000 2653565 530713 SH DFND 478284 0 52429 INSPIREMD INC COM 45779A846 5107450 3133405 SH SOLE 3133405 0 0 INTUITIVE SURGICAL INC COM NEW 46120E602 96208613 208700 SH SOLE 0 0 208700 JADE BIOSCIENCES INC COM NEW 008064206 2599405 185011 SH SOLE 185011 0 0 JANUX THERAPEUTICS INC COM 47103J105 13672040 983600 SH DFND 524700 0 458900 KALVISTA PHARMACEUTICALS INC COM 483497103 1900272 94400 SH SOLE 0 0 94400 KEROS THERAPEUTICS INC COM 492327101 8381071 759155 SH SOLE 759155 0 0 KINIKSA PHARMACEUTICALS INTL ORD SHS CL A G52694109 8695842 180599 SH SOLE 0 0 180599 KRYSTAL BIOTECH INC COM 501147102 17849912 69100 SH DFND 25100 0 44000 LEXEO THERAPEUTICS INC COM 52886X107 20678063 3602450 SH DFND 3203050 0 399400 LIFESTANCE HEALTH GROUP INC COM 53228F101 3185000 500000 SH DFND 312400 0 187600 MBX BIOSCIENCES INC COM 55287L101 108590927 3637887 SH SOLE 3637887 0 0 MDXHEALTH SA SHS NEW B5950S113 285903800 124306000 SH Call SOLE 124306000 0 0 MERCK & CO INC COM 58933Y105 79800386 663400 SH SOLE 0 0 663400 MINERALYS THERAPEUTICS INC COM 603170101 55613061 2052900 SH DFND 534100 0 1518800 MYRIAD GENETICS INC COM 62855J104 122875000 125000000 PRN SOLE 125000000 0 0 NATERA INC COM 632307104 52397380 262000 SH DFND 41000 0 221000 NEKTAR THERAPEUTICS COM NEW 640268306 19786250 275000 SH DFND 130100 0 144900 NEUROPACE INC COM 641288105 27569330 2096527 SH SOLE 2096527 0 0 ORIC PHARMACEUTICALS INC COM 68622P109 34132080 2693929 SH DFND 1075921 0 1618008 PALISADE BIO INC COM 696389402 4082750 2333000 SH SOLE 0 0 2333000 PALVELLA THERAPEUTICS INC NE COM 697947109 16777890 134600 SH DFND 46500 0 88100 PALVELLA THERAPEUTICS INC NE COM 697947109 6232500 50000 SH Call DFND 31300 0 18700 PFIZER INC COM 717081103 54657720 1946500 SH SOLE 0 0 1946500 PHARVARIS N V COM N69605108 5802550 205400 SH SOLE 0 0 205400 PRAXIS PRECISION MEDICINES I COM NEW 74006W207 55577775 172500 SH DFND 33600 0 138900 PRELUDE THERAPEUTICS INC COM 74065P101 37309656 10909256 SH DFND 10119756 0 789500 PRELUDE THERAPEUTICS INC NONVOTING 000000000 19426236 5680186 SH DFND 5596886 0 83300 PROTAGONIST THERAPEUTICS INC COM 74366E102 4437340 42100 SH SOLE 0 0 42100 PTC THERAPEUTICS INC COM 69366J200 3345183 49100 SH SOLE 0 0 49100 Q32 BIO INC COM 746964105 14464177 2252987 SH SOLE 2252987 0 0 QIAGEN NV ORD SHARES N72482156 10010000 250000 SH Call DFND 157700 0 92300 REGENERON PHARMACEUTICALS COM 75886F107 11357808 14700 SH SOLE 0 0 14700 RELMADA THERAPEUTICS INC COM 75955J402 32822413 4715864 SH DFND 2699587 0 2016277 REVOLUTION MEDICINES INC COM 76155X100 5057000 52000 SH SOLE 0 0 52000 RHYTHM PHARMACEUTICALS INC COM 76243J105 27317277 314100 SH DFND 88800 0 225300 SAVARA INC COM 805111101 3467100 635000 SH SOLE 0 0 635000 SHATTUCK LABS INC COM 82024L103 40548397 6306127 SH SOLE 6306127 0 0 SINOVAC BIOTECH LTD SHS P8696W104 184466170 2718735 SH SOLE 0 0 2718735 SIONNA THERAPEUTICS INC COM 829401108 141545843 3530702 SH SOLE 3530702 0 0 SOLENO THERAPEUTICS INC COM 834203309 3348000 100000 SH Call DFND 62400 0 37600 STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106 71114425 1475403 SH DFND 351803 0 1123600 STRYKER CORPORATION COM 863667101 59967675 182500 SH SOLE 0 0 182500 SUTRO BIOPHARMA INC COM SHS 869367201 19956497 801144 SH SOLE 801144 0 0 SYNDAX PHARMACEUTICALS INC COM 87164F105 22479328 962300 SH DFND 351000 0 611300 TECTONIC THERAPEUTIC INC COM 878972108 7004206 226600 SH DFND 149300 0 77300 THERMO FISHER SCIENTIFIC INC COM 883556102 22856145 46500 SH SOLE 0 0 46500 TRAWS PHARMA INC COM NEW 68232V884 1108122 605531 SH SOLE 605531 0 0 TREVI THERAPEUTICS INC COM 89532M101 29280992 2454400 SH DFND 1079400 0 1375000 UNIQURE NV SHS N90064101 34926036 2136149 SH DFND 657349 0 1478800 UPSTREAM BIO INC COM 91678A107 51242301 5693589 SH SOLE 5693589 0 0 UROGEN PHARMA LTD COM M96088105 15741256 875487 SH DFND 194573 0 680914 VERA THERAPEUTICS INC CL A 92337R101 14868847 369596 SH DFND 185296 0 184300 VISTAGEN THERAPEUTICS INC COM 92840H400 1748790 3060000 SH DFND 1420300 0 1639700 WHITEHAWK THERAPEUTICS INC COM 00032Q104 14372700 4166000 SH SOLE 4166000 0 0 XENON PHARMACEUTICALS INC COM 98420N105 61637314 1059971 SH DFND 266971 0 793000