0001172661-22-001456.txt : 20220516
0001172661-22-001456.hdr.sgml : 20220516
20220516161734
ACCESSION NUMBER: 0001172661-22-001456
CONFORMED SUBMISSION TYPE: 13F-HR
PUBLIC DOCUMENT COUNT: 2
CONFORMED PERIOD OF REPORT: 20220331
FILED AS OF DATE: 20220516
DATE AS OF CHANGE: 20220516
EFFECTIVENESS DATE: 20220516
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: ORBIMED ADVISORS LLC
CENTRAL INDEX KEY: 0001055951
IRS NUMBER: 133976876
STATE OF INCORPORATION: DE
FILING VALUES:
FORM TYPE: 13F-HR
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-06774
FILM NUMBER: 22929315
BUSINESS ADDRESS:
STREET 1: 601 LEXINGTON AVENUE
STREET 2: 54TH FLOOR
CITY: NEW YORK
STATE: NY
ZIP: 10022
BUSINESS PHONE: (212) 739-6400
MAIL ADDRESS:
STREET 1: 601 LEXINGTON AVENUE
STREET 2: 54TH FLOOR
CITY: NEW YORK
STATE: NY
ZIP: 10022
13F-HR
1
primary_doc.xml
13F-HR
LIVE
false
true
false
0001055951
XXXXXXXX
03-31-2022
03-31-2022
false
ORBIMED ADVISORS LLC
601 Lexington Avenue
54th Floor
New York
NY
10022
13F HOLDINGS REPORT
028-06774
N
Sven H. Borho
Member
212-739-6400
/s/ Sven H. Borho
New York
NY
05-16-2022
1
145
6167262
1
0001157524
028-10410
ORBIMED CAPITAL LLC
INFORMATION TABLE
2
infotable.xml
89BIO INC
COM
282559103
13794
3658869
SH
SOLE
3658869
0
0
9 METERS BIOPHARMA INC
COM
654405109
6158
10275887
SH
SOLE
10275887
0
0
ABBVIE INC
COM
00287Y109
148428
915600
SH
DFND
93200
0
822400
ABCELLERA BIOLOGICS INC
COM
00288U106
40762
4180768
SH
SOLE
4180768
0
0
ACHILLES THERAPEUTICS PLC
SPONSORED ADS
00449L102
4659
1584845
SH
DFND
178735
0
1406110
ACLARIS THERAPEUTICS INC
COM
00461U105
27237
1579900
SH
DFND
258400
0
1321500
ACUTUS MED INC
COM
005111109
3681
2648386
SH
SOLE
2648386
0
0
ADAGIO THERAPEUTICS INC
COM
00534A102
23055
5056000
SH
SOLE
5056000
0
0
ADICET BIO INC
COM
007002108
148719
7447141
SH
SOLE
7447141
0
0
AEGLEA BIOTHERAPEUTICS INC
COM
00773J103
6799
2956124
SH
SOLE
2956124
0
0
AEROVATE THERAPEUTICS INC
COM
008064107
9347
509949
SH
DFND
107114
0
402835
ALBIREO PHARMA INC
COM
01345P106
5787
194000
SH
SOLE
194000
0
0
ALPINE IMMUNE SCIENCES INC
COM
02083G100
36612
4081592
SH
SOLE
4081592
0
0
ALX ONCOLOGY HLDGS INC
COM
00166B105
10507
621700
SH
DFND
178700
0
443000
AMGEN INC
COM
031162100
13808
57100
SH
SOLE
0
0
57100
APTINYX INC
COM
03836N103
1222
538500
SH
SOLE
538500
0
0
ARCUTIS BIOTHERAPEUTICS INC
COM
03969K108
116982
6073850
SH
DFND
4267564
0
1806286
ARGENX SE
SPONSORED ADR
04016X101
53540
169800
SH
SOLE
0
0
169800
ASLAN PHARMACEUTICALS LTD
ADS
04522R101
1747
1941219
SH
SOLE
0
0
1941219
BELLUS HEALTH INC NEW
COM NEW
07987C204
10068
1454800
SH
SOLE
1454800
0
0
BIOGEN INC
COM
09062X103
24830
117900
SH
DFND
13300
0
104600
BIOHAVEN PHARMACTL HLDG CO L
COM
G11196105
85256
719034
SH
SOLE
719034
0
0
BIOMARIN PHARMACEUTICAL INC
COM
09061G101
126986
1647030
SH
DFND
125350
0
1521680
BIOMX INC
COM
09090D103
5430
2813489
SH
SOLE
2813489
0
0
BOSTON SCIENTIFIC CORP
COM
101137107
203712
4599500
SH
DFND
480000
0
4119500
BRIDGEBIO PHARMA INC
NOTE 2.250% 2/0
10806XAD4
14416
30000000
PRN
SOLE
30000000
0
0
BRIDGEBIO PHARMA INC
NOTE 2.500% 3/1
10806XAB8
12000
20000000
PRN
SOLE
20000000
0
0
BRISTOL-MYERS SQUIBB CO
COM
110122108
190440
2607700
SH
DFND
186000
0
2421700
BURNING ROCK BIOTECH LTD
SPONSORED ADS
12233L107
13493
1452402
SH
DFND
125678
0
1326724
CABALETTA BIO INC
COM
12674W109
1172
577509
SH
DFND
275000
0
302509
CELLDEX THERAPEUTICS INC NEW
COM NEW
15117B202
13832
406100
SH
DFND
49600
0
356500
CHEMOMAB THERAPEUTICS LTD
SPONSORED ADS
16385C104
12375
2578174
SH
SOLE
2578174
0
0
CHINOOK THERAPEUTICS INC
COM
16961L106
23203
1418300
SH
DFND
478300
0
940000
COMPASS THERAPEUTICS INC
COM
20454B104
29651
21642975
SH
DFND
18071547
0
3571428
CORVUS PHARMACEUTICALS INC
COM
221015100
11388
6943654
SH
SOLE
6943654
0
0
CRINETICS PHARMACEUTICALS IN
COM
22663K107
70171
3196876
SH
SOLE
3196876
0
0
CULLINAN ONCOLOGY INC
COM
230031106
7023
670787
SH
SOLE
670787
0
0
CYBIN INC
COM
23256X100
8598
10524300
SH
SOLE
0
0
10524300
CYTOMX THERAPEUTICS INC
COM
23284F105
5674
2124975
SH
DFND
544559
0
1580416
DANAHER CORPORATION
5% CONV PFD B
235851409
12696
8039
PRN
SOLE
0
0
8039
DECIBEL THERAPEUTICS INC
COM
24343R106
15033
4945192
SH
DFND
4061774
0
883418
DEXCOM INC
COM
252131107
76689
149900
SH
DFND
9600
0
140300
EDGEWISE THERAPEUTICS INC
COM
28036F105
135263
13944680
SH
DFND
13679055
0
265625
EDWARDS LIFESCIENCES CORP
COM
28176E108
123759
1051300
SH
DFND
85000
0
966300
ERASCA INC
COM
29479A108
14342
1667693
SH
SOLE
0
0
1667693
EVOLENT HEALTH INC
CL A
30050B101
45220
1400000
SH
SOLE
0
0
1400000
EXSCIENTIA PLC
ADS
30223G102
1800
125000
SH
SOLE
125000
0
0
FIELD TRIP HEALTH LTD
COM
31656R102
762
576930
SH
SOLE
0
0
576930
FUSION PHARMACEUTICALS INC
COM
36118A100
25056
3224770
SH
DFND
2930670
0
294100
GALAPAGOS NV
SPON ADR
36315X101
12914
208225
SH
DFND
11800
0
196425
GALECTO INC
COM
36322Q107
9000
4090937
SH
DFND
3803255
0
287682
GEMINI THERAPEUTICS INC
COM
36870G105
8098
5826224
SH
SOLE
5826224
0
0
GH RESEARCH PLC
ORDINARY SHARES
G3855L106
26132
1428732
SH
DFND
125000
0
1303732
GILEAD SCIENCES INC
COM
375558103
17098
287600
SH
SOLE
0
0
287600
GLOBAL BLOOD THERAPEUTICS IN
COM
37890U108
54613
1576600
SH
DFND
52700
0
1523900
GLOBAL BLOOD THERAPEUTICS IN
COM
37890U108
1732
50000
SH
Call
DFND
24000
0
26000
GRACELL BIOTECHNOLOGIES INC
SPONSORED ADS
38406L103
18372
7884870
SH
DFND
5970672
0
1914198
GRAPHITE BIO INC
COM
38870X104
7986
1565812
SH
DFND
430000
0
1135812
GRAYBUG VISION INC
COM SHS
38942Q103
5121
4163347
SH
SOLE
4163347
0
0
GUARDANT HEALTH INC
COM
40131M109
87794
1325400
SH
DFND
108700
0
1216700
HARPOON THERAPEUTICS INC
COM
41358P106
15106
3039508
SH
DFND
1371608
0
1667900
HORIZON THERAPEUTICS PUB L
SHS
G46188101
231100
2196555
SH
DFND
185000
0
2011555
HUMANA INC
COM
444859102
166104
381700
SH
DFND
33000
0
348700
I MAB
SPONSORED ADS
44975P103
1805
111120
SH
DFND
25000
0
86120
IKENA ONCOLOGY INC
COM
45175G108
17897
2933941
SH
DFND
1936886
0
997055
IKENA ONCOLOGY INC
NONVOTING
000000000
37914
6215466
SH
DFND
5586311
0
629155
ILLUMINA INC
COM
452327109
15758
45100
SH
SOLE
0
0
45100
IMARA INC
COM
45249V107
8247
4386568
SH
DFND
4199068
0
187500
IMMUNOCORE HLDGS PLC
ADS
45258D105
3830
128100
SH
SOLE
128100
0
0
INTUITIVE SURGICAL INC
COM NEW
46120E602
161157
534200
SH
DFND
36000
0
498200
IOVANCE BIOTHERAPEUTICS INC
COM
462260100
110440
6633006
SH
DFND
1263700
0
5369306
JANUX THERAPEUTICS INC
COM
47103J105
40674
2836386
SH
DFND
2489664
0
346722
JOUNCE THERAPEUTICS INC
COM
481116101
19419
2859900
SH
DFND
659700
0
2200200
KEROS THERAPEUTICS INC
COM
492327101
91327
1679417
SH
DFND
1268734
0
410683
KINNATE BIOPHARMA INC
COM
49705R105
45531
4043629
SH
DFND
3593629
0
450000
LANDOS BIOPHARMA INC
COM
515069102
418
283217
SH
SOLE
0
0
283217
LOGICBIO THERAPEUTICS INC
COM
54142F102
5758
8466783
SH
DFND
7948265
0
518518
LONGBOARD PHARMACEUTICALS IN
COM
54300N103
606
113500
SH
SOLE
0
0
113500
MAGENTA THERAPEUTICS INC
COM
55910K108
6528
2250953
SH
DFND
543000
0
1707953
MEIRAGTX HLDGS PLC
COM
G59665102
45659
3296666
SH
DFND
133500
0
3163166
MEREO BIOPHARMA GROUP PLC
ADS
589492107
11373
10154810
SH
DFND
4471023
0
5683787
MEREO BIOPHARMA GROUP PLC
ADS
589492107
7963
7109954
PRN
DFND
4739969
0
2369985
MERSANA THERAPEUTICS INC
COM
59045L106
19108
4788900
SH
DFND
1353000
0
3435900
MILESTONE PHARMACEUTICALS IN
COM
59935V107
16588
2583821
SH
SOLE
0
0
2583821
MIRATI THERAPEUTICS INC
COM
60468T105
134060
1630500
SH
DFND
220600
0
1409900
MIRUM PHARMACEUTICALS INC
COM
604749101
595
27000
SH
SOLE
27000
0
0
NANOSTRING TECHNOLOGIES INC
NOTE 2.625% 3/0
63009RAD1
6086
6000000
PRN
SOLE
0
0
6000000
NANOSTRING TECHNOLOGIES INC
COM
63009R109
40219
1157387
SH
DFND
67400
0
1089987
NATERA INC
COM
632307104
6102
150000
SH
Call
DFND
72500
0
77500
NATERA INC
COM
632307104
64900
1595385
SH
DFND
125000
0
1470385
NEUROCRINE BIOSCIENCES INC
COM
64125C109
82080
875515
SH
DFND
52970
0
822545
NEUROPACE INC
COM
641288105
32941
4012281
SH
SOLE
4012281
0
0
NEXTCURE INC
COM
65343E108
13176
2711013
SH
SOLE
2711013
0
0
ONCOCYTE CORP
COM
68235C107
5206
3493800
SH
DFND
1188800
0
2305000
ORIC PHARMACEUTICALS INC
COM
68622P109
11148
2087568
SH
SOLE
2087568
0
0
OWLET INC
*W EXP 09/14/202
69120X115
170
220704
SH
DFND
82544
0
138160
PASSAGE BIO INC
COM
702712100
22729
7331999
SH
DFND
6316423
0
1015576
PFIZER INC
COM
717081103
202188
3905500
SH
DFND
275000
0
3630500
PMV PHARMACEUTICALS INC
COM
69353Y103
142730
6855423
SH
DFND
6589330
0
266093
PRELUDE THERAPEUTICS INC
COM
74065P101
69274
10039691
SH
DFND
9250191
0
789500
PRELUDE THERAPEUTICS INC
NONVOTING
000000000
39193
5680186
SH
DFND
5596886
0
83300
PROTARA THERAPEUTICS INC
COM STK
74365U107
4245
830641
SH
DFND
158900
0
671741
PULMONX CORP
COM
745848101
10792
435000
SH
DFND
83600
0
351400
PYXIS ONCOLOGY INC
COMMON STOCK
747324101
580
143640
SH
DFND
49540
0
94100
RAPT THERAPEUTICS INC
COM
75382E109
7945
361300
SH
DFND
144300
0
217000
REPARE THERAPEUTICS INC
COM
760273102
47312
3322488
SH
DFND
3177041
0
145447
RXSIGHT INC
COM
78349D107
17128
1383500
SH
DFND
321000
0
1062500
SAREPTA THERAPEUTICS INC
COM
803607100
3054
39100
SH
SOLE
39100
0
0
SCPHARMACEUTICALS INC
COM
810648105
27248
4797148
SH
SOLE
4797148
0
0
SEAGEN INC
COM
81181C104
96182
667700
SH
DFND
66100
0
601600
SI-BONE INC
COM
825704109
70947
3139247
SH
SOLE
0
0
3139247
SIERRA ONCOLOGY INC
COM NEW
82640U404
62971
1964770
SH
DFND
1738066
0
226704
SIGHT SCIENCES INC
COM
82657M105
2312
200000
SH
SOLE
0
0
200000
SIGNIFY HEALTH INC
CL A COM
82671G100
11266
620700
SH
SOLE
0
0
620700
SILVERBACK THERAPEUTICS INC
COM
82835W108
30681
8740887
SH
DFND
7788510
0
952377
SINGULAR GENOMICS SYSTEMS IN
COM
82933R100
14518
2300792
SH
DFND
985897
0
1314895
SONENDO INC
COM
835431107
7892
1968180
SH
SOLE
1968180
0
0
SPDR SER TR
S&P BIOTECH
78464A870
10049
111800
SH
SOLE
111800
0
0
SPRINGWORKS THERAPEUTICS INC
COM
85205L107
340238
6028307
SH
SOLE
6028307
0
0
STRYKER CORPORATION
COM
863667101
122206
457100
SH
DFND
34000
0
423100
SYNDAX PHARMACEUTICALS INC
COM
87164F105
37511
2158300
SH
DFND
387000
0
1771300
SYNLOGIC INC
COM
87166L100
14472
6029995
SH
SOLE
6029995
0
0
TALARIS THERAPEUTICS INC
COM
87410C104
2433
247240
SH
SOLE
0
0
247240
TELA BIO INC
COM
872381108
35210
3027542
SH
SOLE
3027542
0
0
TENET HEALTHCARE CORP
COM NEW
88033G407
54009
628300
SH
DFND
51000
0
577300
TERNS PHARMACEUTICALS INC
COM
880881107
11260
3791204
SH
SOLE
3791204
0
0
THERAVANCE BIOPHARMA INC
COM
G8807B106
31115
3254713
SH
DFND
34280
0
3220433
THERMO FISHER SCIENTIFIC INC
COM
883556102
71232
120600
SH
DFND
12200
0
108400
THESEUS PHARMACEUTICALS INC
COM
88369M101
196490
17041668
SH
SOLE
17041668
0
0
TRICIDA INC
COM
89610F101
84509
10280947
SH
SOLE
10280947
0
0
TURNING POINT THERAPEUTICS I
COM
90041T108
54209
2018950
SH
DFND
1656450
0
362500
ULTRAGENYX PHARMACEUTICAL IN
COM
90400D108
16528
227600
SH
DFND
60300
0
167300
UNIQURE NV
SHS
N90064101
16611
919249
SH
DFND
94400
0
824849
UNITEDHEALTH GROUP INC
COM
91324P102
150033
294200
SH
DFND
27000
0
267200
VAXCYTE INC
COM
92243G108
36555
1513659
SH
DFND
207945
0
1305714
VECTIVBIO HLDG AG
ORD SHS
H9060V101
25108
5330704
SH
DFND
5037404
0
293300
VENTYX BIOSCIENCES INC
COM
92332V107
17496
1289280
SH
SOLE
1289280
0
0
VERONA PHARMA PLC
SPONSORED ADS
925050106
28417
5694841
SH
DFND
5028174
0
666667
VERTEX PHARMACEUTICALS INC
COM
92532F100
104440
400200
SH
DFND
27000
0
373200
VIGIL NEUROSCIENCE INC
COM
92673K108
2891
411191
SH
SOLE
411191
0
0
VISTAGEN THERAPEUTICS INC
COM NEW
92840H202
16008
12909283
SH
DFND
2390043
0
10519240
VOR BIOPHARMA INC
COM
929033108
5033
833333
SH
SOLE
0
0
833333
X4 PHARMACEUTICALS INC
COM
98420X103
2404
1373849
SH
SOLE
1373849
0
0
XENON PHARMACEUTICALS INC
COM
98420N105
20971
686000
SH
DFND
55000
0
631000
XTANT MED HLDGS INC
COM NEW
98420P308
49602
72943918
SH
SOLE
72943918
0
0