0001172661-21-002332.txt : 20211115
0001172661-21-002332.hdr.sgml : 20211115
20211115160535
ACCESSION NUMBER: 0001172661-21-002332
CONFORMED SUBMISSION TYPE: 13F-HR
PUBLIC DOCUMENT COUNT: 2
CONFORMED PERIOD OF REPORT: 20210930
FILED AS OF DATE: 20211115
DATE AS OF CHANGE: 20211115
EFFECTIVENESS DATE: 20211115
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: ORBIMED ADVISORS LLC
CENTRAL INDEX KEY: 0001055951
IRS NUMBER: 133976876
STATE OF INCORPORATION: DE
FILING VALUES:
FORM TYPE: 13F-HR
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-06774
FILM NUMBER: 211410327
BUSINESS ADDRESS:
STREET 1: 601 LEXINGTON AVENUE
STREET 2: 54TH FLOOR
CITY: NEW YORK
STATE: NY
ZIP: 10022
BUSINESS PHONE: (212) 739-6400
MAIL ADDRESS:
STREET 1: 601 LEXINGTON AVENUE
STREET 2: 54TH FLOOR
CITY: NEW YORK
STATE: NY
ZIP: 10022
13F-HR
1
primary_doc.xml
13F-HR
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0001055951
XXXXXXXX
09-30-2021
09-30-2021
false
ORBIMED ADVISORS LLC
601 Lexington Avenue
54th Floor
New York
NY
10022
13F HOLDINGS REPORT
028-06774
N
Sven H. Borho
Member
212-739-6400
/s/ Sven H. Borho
New York
NY
11-15-2021
1
173
9099330
1
0001157524
028-10410
ORBIMED CAPITAL LLC
INFORMATION TABLE
2
infotable.xml
89BIO INC
COM
282559103
73060
3729442
SH
SOLE
3729442
0
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9 METERS BIOPHARMA INC
COM
654405109
11136
8565974
SH
SOLE
8565974
0
0
AADI BIOSCIENCES INC
COM
00032Q104
10170
346262
SH
SOLE
346262
0
0
ABBVIE INC
COM
00287Y109
153240
1420600
SH
DFND
228100
0
1192500
ABCELLERA BIOLOGICS INC
COM
00288U106
83783
4180768
SH
SOLE
4180768
0
0
ACHILLES THERAPEUTICS PLC
SPONSORED ADS
00449L102
12346
1584845
SH
DFND
178735
0
1406110
ACLARIS THERAPEUTICS INC
COM
00461U105
11732
651783
SH
SOLE
0
0
651783
ACUTUS MED INC
COM
005111109
23412
2648386
SH
SOLE
2648386
0
0
ADAGENE INC
ADS
005329107
3950
275000
SH
SOLE
275000
0
0
ADAGIO THERAPEUTICS INC
COM
00534A102
227399
5383500
SH
SOLE
5383500
0
0
ADICET BIO INC
COM
007002108
56706
7232856
SH
SOLE
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0
0
AEGLEA BIOTHERAPEUTICS INC
COM
00773J103
31923
4015524
SH
SOLE
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0
AEROVATE THERAPEUTICS INC
COM
008064107
11239
535714
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DFND
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ALPINE IMMUNE SCIENCES INC
COM
02083G100
43551
4081592
SH
SOLE
4081592
0
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ALX ONCOLOGY HLDGS INC
COM
00166B105
11079
150000
SH
SOLE
0
0
150000
AMGEN INC
COM
031162100
12142
57100
SH
SOLE
0
0
57100
ANTHEM INC
COM
036752103
77207
207100
SH
DFND
29600
0
177500
APPLIED THERAPEUTICS INC
COM
03828A101
37473
2257387
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DFND
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0
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APTINYX INC
COM
03836N103
359
153285
SH
SOLE
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APTOSE BIOSCIENCES INC
COM NEW
03835T200
5656
2594348
SH
SOLE
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0
2594348
ARCUTIS BIOTHERAPEUTICS INC
COM
03969K108
145104
6073850
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DFND
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1806286
ASLAN PHARMACEUTICALS LTD
ADS
04522R101
3507
1970000
SH
SOLE
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1970000
ASTRAZENECA PLC
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046353108
312
5200
SH
Call
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0
3000
BELLUS HEALTH INC NEW
COM NEW
07987C204
14960
2454800
SH
SOLE
2454800
0
0
BIOGEN INC
COM
09062X103
66276
234200
SH
DFND
17300
0
216900
BIOMARIN PHARMACEUTICAL INC
COM
09061G101
8571
110900
SH
SOLE
0
0
110900
BIOMX INC
COM
09090D103
8609
2813489
SH
SOLE
2813489
0
0
BOSTON SCIENTIFIC CORP
COM
101137107
253120
5833600
SH
DFND
827400
0
5006200
BRISTOL-MYERS SQUIBB CO
COM
110122108
267176
4515400
SH
DFND
569100
0
3946300
BURNING ROCK BIOTECH LTD
SPONSORED ADS
12233L107
33189
1856201
SH
DFND
197799
0
1658402
CABALETTA BIO INC
COM
12674W109
3679
302509
SH
SOLE
0
0
302509
CATALYST BIOSCIENCES INC
COM NEW
14888D208
11145
2711600
SH
DFND
593000
0
2118600
CELLDEX THERAPEUTICS INC NEW
COM NEW
15117B202
22368
414300
SH
DFND
57800
0
356500
CENTURY THERAPEUTICS INC
COM
15673T100
10241
407047
SH
DFND
115414
0
291633
CHEMOMAB THERAPEUTICS LTD
SPONSORED ADS
16385C104
28566
2578174
SH
SOLE
2578174
0
0
CHINOOK THERAPEUTICS INC
COM
16961L106
18127
1420637
SH
DFND
420636
0
1000001
CONVEY HLDG PARENT INC
COM
21258C108
8400
1000000
SH
DFND
107000
0
893000
CORVUS PHARMACEUTICALS INC
COM
221015100
33607
6943654
SH
SOLE
6943654
0
0
CRINETICS PHARMACEUTICALS IN
COM
22663K107
63084
2996876
SH
SOLE
2996876
0
0
CRISPR THERAPEUTICS AG
NAMEN AKT
H17182108
68580
612700
SH
DFND
47500
0
565200
CTI BIOPHARMA CORP
COM
12648L601
22186
7520600
SH
SOLE
7520600
0
0
CULLINAN ONCOLOGY INC
COM
230031106
25868
1146145
SH
DFND
959245
0
186900
CURIS INC
COM NEW
231269200
27573
3521400
SH
DFND
371600
0
3149800
CVRX INC
COM
126638105
13230
799861
SH
DFND
148300
0
651561
CYBIN INC
COM
23256X100
29463
13447121
SH
SOLE
0
0
13447121
CYTEK BIOSCIENCES INC
COM
23285D109
41174
1923139
SH
DFND
961569
0
961570
CYTOMX THERAPEUTICS INC
COM
23284F105
9273
1821868
SH
DFND
729668
0
1092200
DECIBEL THERAPEUTICS INC
COM
24343R106
38127
4945192
SH
DFND
4061774
0
883418
DECIPHERA PHARMACEUTICALS IN
COM
24344T101
74183
2183143
SH
DFND
294600
0
1888543
DEXCOM INC
COM
252131107
124684
228000
SH
DFND
23600
0
204400
DICE THERAPEUTICS INC
COM
23345J104
14410
440000
SH
DFND
176000
0
264000
EDGEWISE THERAPEUTICS INC
COM
28036F105
231482
13944680
SH
DFND
13679055
0
265625
EDWARDS LIFESCIENCES CORP
COM
28176E108
127520
1126400
SH
DFND
151600
0
974800
ERASCA INC
COM
29479A108
45991
2167341
SH
SOLE
0
0
2167341
EVOLENT HEALTH INC
CL A
30050B101
10695
345000
SH
SOLE
0
0
345000
EVOLENT HEALTH INC
CL A
30050B101
7750
250000
SH
Call
DFND
105000
0
145000
FIELD TRIP HEALTH LTD
COM
31656R102
6996
1538470
SH
SOLE
0
0
1538470
FLEXION THERAPEUTICS INC
COM
33938J106
16893
2769383
SH
DFND
301600
0
2467783
FLUIDIGM CORP DEL
COM
34385P108
30311
4599571
SH
DFND
484800
0
4114771
FUSION PHARMACEUTICALS INC
COM
36118A100
25540
3224770
SH
DFND
2930670
0
294100
GALAPAGOS NV
SPON ADR
36315X101
38061
723457
SH
DFND
100900
0
622557
GALECTO INC
COM
36322Q107
14686
4090937
SH
DFND
3803255
0
287682
GEMINI THERAPEUTICS INC
COM
36870G105
23538
5826224
SH
SOLE
5826224
0
0
GH RESEARCH PLC
ORDINARY SHARES
G3855L106
31516
1428666
SH
DFND
125000
0
1303666
GILEAD SCIENCES INC
COM
375558103
20089
287600
SH
SOLE
0
0
287600
GRACELL BIOTECHNOLOGIES INC
SPONSORED ADS
38406L103
109363
7884870
SH
DFND
5970672
0
1914198
GRAPHITE BIO INC
COM
38870X104
23764
1449904
SH
DFND
314092
0
1135812
GRAYBUG VISION INC
COM SHS
38942Q103
13822
4163347
SH
SOLE
4163347
0
0
GUARDANT HEALTH INC
COM
40131M109
153437
1227400
SH
DFND
108700
0
1118700
HARPOON THERAPEUTICS INC
COM
41358P106
20629
2611308
SH
DFND
943408
0
1667900
HCA HEALTHCARE INC
COM
40412C101
47039
193800
SH
DFND
20200
0
173600
HEALTH SCIENCES ACQ CORP 2
ORD SHS
G4411D109
4945
500000
SH
DFND
100000
0
400000
HORIZON THERAPEUTICS PUB L
SHS
G46188101
285938
2610355
SH
DFND
306300
0
2304055
HUMACYTE INC
COM
44486Q103
17415
1500000
SH
DFND
300000
0
1200000
HUMANA INC
COM
444859102
130365
335000
SH
DFND
55000
0
280000
I MAB
SPONSORED ADS
44975P103
8055
111120
SH
DFND
25000
0
86120
IKENA ONCOLOGY INC
COM
45175G108
37026
2933941
SH
DFND
1936886
0
997055
IKENA ONCOLOGY INC
NONVOTING
000000000
78439
6215466
SH
DFND
5586311
0
629155
IMARA INC
COM
45249V107
17897
4386568
SH
DFND
4199068
0
187500
IMMUNOGEN INC
COM
45253H101
84471
14897914
SH
DFND
1852600
0
13045314
INFLARX NV
COM
N44821101
2756
1064118
SH
SOLE
0
0
1064118
INOZYME PHARMA INC
COM
45790W108
3407
294000
SH
SOLE
294000
0
0
INTELLIA THERAPEUTICS INC
COM
45826J105
7137
53200
SH
SOLE
0
0
53200
INTUITIVE SURGICAL INC
COM NEW
46120E602
138783
139600
SH
DFND
20800
0
118800
IOVANCE BIOTHERAPEUTICS INC
COM
462260100
163868
6645100
SH
DFND
1337800
0
5307300
JANUX THERAPEUTICS INC
COM
47103J105
74978
3466386
SH
DFND
3042764
0
423622
JOUNCE THERAPEUTICS INC
COM
481116101
19731
2655600
SH
DFND
659700
0
1995900
KALA PHARMACEUTICALS INC
COM
483119103
9010
3438998
SH
DFND
2966523
0
472475
KEROS THERAPEUTICS INC
COM
492327101
66438
1679417
SH
DFND
1268734
0
410683
KEZAR LIFE SCIENCES INC
COM
49372L100
9936
1150000
SH
SOLE
1150000
0
0
KEZAR LIFE SCIENCES INC
COM
49372L100
980
113400
SH
Call
DFND
47000
0
66400
KINNATE BIOPHARMA INC
COM
49705R105
88579
3847929
SH
DFND
3397929
0
450000
LANDOS BIOPHARMA INC
COM
515069102
4135
283217
SH
SOLE
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0
283217
LOGICBIO THERAPEUTICS INC
COM
54142F102
38778
8466783
SH
DFND
7948265
0
518518
LONGBOARD PHARMACEUTICALS IN
COM
54300N103
1004
113500
SH
SOLE
0
0
113500
MAGENTA THERAPEUTICS INC
COM
55910K108
13781
1892953
SH
DFND
185000
0
1707953
MEIRAGTX HLDGS PLC
COM
G59665102
54077
4102925
SH
DFND
133500
0
3969425
MERCK & CO INC
COM
58933Y105
280341
3732400
SH
DFND
465000
0
3267400
MEREO BIOPHARMA GROUP PLC
ADS
589492107
41781
17264764
SH
DFND
9210992
0
8053772
MERSANA THERAPEUTICS INC
COM
59045L106
27242
2888847
SH
DFND
464000
0
2424847
MILESTONE PHARMACEUTICALS IN
COM
59935V107
14754
2583821
SH
SOLE
0
0
2583821
MIRATI THERAPEUTICS INC
COM
60468T105
242933
1373200
SH
DFND
222700
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NANOBIOTIX SA
SPONSORED ADS
63009J107
5680
500000
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SOLE
0
0
500000
NANOSTRING TECHNOLOGIES INC
COM
63009R109
26694
556000
SH
DFND
62900
0
493100
NANOSTRING TECHNOLOGIES INC
NOTE 2.625% 3/0
63009RAD1
7855
6000000
PRN
SOLE
0
0
6000000
NATERA INC
COM
632307104
175273
1572800
SH
DFND
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NAUTILUS BIOTECHNOLOGY INC
COM
63909J108
8920
1452774
SH
DFND
353674
0
1099100
NEUROCRINE BIOSCIENCES INC
COM
64125C109
114326
1192015
SH
DFND
137470
0
1054545
NEUROPACE INC
COM
641288105
63595
4012281
SH
SOLE
4012281
0
0
NEXTCURE INC
COM
65343E108
18272
2711013
SH
SOLE
2711013
0
0
NOVAVAX INC
COM NEW
670002401
9449
45580
SH
SOLE
0
0
45580
NURIX THERAPEUTICS INC
COM
67080M103
17334
578583
SH
DFND
73400
0
505183
OAK STR HEALTH INC
COM
67181A107
56493
1328300
SH
DFND
136700
0
1191600
OLEMA PHARMACEUTICALS INC
COM
68062P106
22263
807792
SH
DFND
282392
0
525400
ONCOCYTE CORP
COM
68235C107
10167
2856000
SH
DFND
551000
0
2305000
ORIC PHARMACEUTICALS INC
COM
68622P109
48879
2337574
SH
DFND
2212571
0
125003
OWLET INC
*W EXP 09/14/202
69120X115
207
220704
SH
Call
DFND
82544
0
138160
OWLET INC
COM CL A
69120X107
6708
1200000
SH
DFND
200000
0
1000000
PASSAGE BIO INC
COM
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69350
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SH
DFND
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PHASEBIO PHARMACEUTICALS INC
COM
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551
177113
SH
SOLE
177113
0
0
PMV PHARMACEUTICALS INC
COM
69353Y103
218447
7330423
SH
DFND
6589330
0
741093
PRELUDE THERAPEUTICS INC
COM
74065P101
313740
10039691
SH
DFND
9250191
0
789500
PRELUDE THERAPEUTICS INC
NONVOTING
000000000
177506
5680186
SH
DFND
5596886
0
83300
PROCEPT BIOROBOTICS CORP
COM
74276L105
5150
135000
SH
DFND
39700
0
95300
PROGYNY INC
COM
74340E103
71123
1270045
SH
DFND
151085
0
1118960
PROMETHEUS BIOSCIENCES INC
COM
74349U108
5928
250000
SH
SOLE
0
0
250000
PROTARA THERAPEUTICS INC
COM STK
74365U107
3114
450000
SH
DFND
60000
0
390000
PULMONX CORP
COM
745848101
15651
435000
SH
DFND
83600
0
351400
REGENERON PHARMACEUTICALS
COM
75886F107
8206
13560
SH
DFND
1860
0
11700
REPARE THERAPEUTICS INC
COM
760273102
87182
3322488
SH
DFND
3177041
0
145447
REPLIGEN CORP
COM
759916109
4255
14724
SH
SOLE
14724
0
0
RXSIGHT INC
COM
78349D107
15838
1250000
SH
DFND
187500
0
1062500
SAREPTA THERAPEUTICS INC
COM
803607100
5983
64700
SH
SOLE
64700
0
0
SCPHARMACEUTICALS INC
COM
810648105
31901
4797148
SH
SOLE
4797148
0
0
SEAGEN INC
COM
81181C104
45506
268000
SH
DFND
24000
0
244000
SELECT MED HLDGS CORP
COM
81619Q105
45976
1271100
SH
DFND
135900
0
1135200
SI-BONE INC
COM
825704109
48152
2248000
SH
SOLE
0
0
2248000
SIERRA ONCOLOGY INC
COM NEW
82640U404
32383
1477320
SH
DFND
1306860
0
170460
SIGHT SCIENCES INC
COM
82657M105
4540
200000
SH
SOLE
0
0
200000
SILVERBACK THERAPEUTICS INC
COM
82835W108
87234
8740887
SH
DFND
7788510
0
952377
SINGULAR GENOMICS SYSTEMS IN
COM
82933R100
22363
1998521
SH
DFND
683626
0
1314895
SINOVAC BIOTECH LTD
SHS
P8696W104
78400
2839500
SH
SOLE
0
0
2839500
SPDR SER TR
S&P BIOTECH
78464A870
133969
1065700
SH
DFND
167800
0
897900
SPRINGWORKS THERAPEUTICS INC
COM
85205L107
382436
6028307
SH
SOLE
6028307
0
0
STRONGBRIDGE BIOPHARMA PLC
SHS USD
G85347105
1621
794675
SH
DFND
114300
0
680375
STRYKER CORPORATION
COM
863667101
88979
337400
SH
DFND
53200
0
284200
SURFACE ONCOLOGY INC
COM
86877M209
6886
909666
SH
DFND
188546
0
721120
SYNDAX PHARMACEUTICALS INC
COM
87164F105
3642
190600
SH
SOLE
0
0
190600
SYNLOGIC INC
COM
87166L100
18391
6029995
SH
SOLE
6029995
0
0
SYROS PHARMACEUTICALS INC
COM
87184Q107
8214
1837500
SH
SOLE
0
0
1837500
TALARIS THERAPEUTICS INC
COM
87410C104
3353
247240
SH
SOLE
0
0
247240
TELA BIO INC
COM
872381108
41356
3027542
SH
SOLE
3027542
0
0
TENET HEALTHCARE CORP
COM NEW
88033G407
20709
311700
SH
DFND
44200
0
267500
TERNS PHARMACEUTICALS INC
COM
880881107
39504
3791204
SH
SOLE
3791204
0
0
THERAVANCE BIOPHARMA INC
COM
G8807B106
43624
5895159
SH
DFND
558385
0
5336774
THERMO FISHER SCIENTIFIC INC
COM
883556102
63018
110300
SH
DFND
16800
0
93500
TRICIDA INC
COM
89610F101
44610
9614280
SH
SOLE
9614280
0
0
TURNING POINT THERAPEUTICS I
COM
90041T108
156863
2361327
SH
DFND
1743950
0
617377
UNIQURE NV
SHS
N90064101
18744
585574
SH
DFND
94400
0
491174
UNITEDHEALTH GROUP INC
COM
91324P102
152271
389700
SH
DFND
56500
0
333200
VAXCYTE INC
COM
92243G108
26249
1034665
SH
SOLE
0
0
1034665
VECTIVBIO HLDG AG
ORD SHS
H9060V101
39578
5123304
SH
DFND
4830004
0
293300
VERONA PHARMA PLC
SPONSORED ADS
925050106
31208
5694841
SH
DFND
5028174
0
666667
VERRICA PHARMACEUTICALS INC
COM
92511W108
18497
1479733
SH
SOLE
1479733
0
0
VERTEX PHARMACEUTICALS INC
COM
92532F100
159152
877400
SH
DFND
89500
0
787900
VISTAGEN THERAPEUTICS INC
COM NEW
92840H202
35371
12909283
SH
DFND
2390043
0
10519240
VOR BIOPHARMA INC
COM
929033108
13067
833333
SH
SOLE
0
0
833333
WM TECHNOLOGY INC
*W EXP 06/16/202
92971A117
649
150200
SH
Call
SOLE
0
0
150200
WM TECHNOLOGY INC
COM
92971A109
10156
700400
SH
SOLE
0
0
700400
X4 PHARMACEUTICALS INC
COM
98420X103
7268
1373849
SH
SOLE
1373849
0
0
XENON PHARMACEUTICALS INC
COM
98420N105
7289
477000
SH
DFND
250000
0
227000
XTANT MED HLDGS INC
COM NEW
98420P308
80890
72873494
SH
SOLE
72873494
0
0
ZIMMER BIOMET HOLDINGS INC
COM
98956P102
96715
660800
SH
DFND
68400
0
592400