Managing Member

0001172661-15-001654.txt : 20150814 0001172661-15-001654.hdr.sgml : 20150814 20150814162226 ACCESSION NUMBER: 0001172661-15-001654 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20150630 FILED AS OF DATE: 20150814 DATE AS OF CHANGE: 20150814 EFFECTIVENESS DATE: 20150814 FILER: COMPANY DATA: COMPANY CONFORMED NAME: ORBIMED ADVISORS LLC CENTRAL INDEX KEY: 0001055951 IRS NUMBER: 133976876 STATE OF INCORPORATION: DE FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-06774 FILM NUMBER: 151056182 BUSINESS ADDRESS: STREET 1: 601 LEXINGTON AVENUE STREET 2: 54TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10022 BUSINESS PHONE: (212) 739-6400 MAIL ADDRESS: STREET 1: 601 LEXINGTON AVENUE STREET 2: 54TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10022 13F-HR 1 primary_doc.xml 13F-HR LIVE false true false 0001055951 XXXXXXXX 06-30-2015 06-30-2015 false ORBIMED ADVISORS LLC

601 Lexington Avenue 54th Floor New York NY 10022

13F HOLDINGS REPORT 028-06774 N Samuel D. Isaly Managing Member 212-739-6400 /s/ Samuel D. Isaly New York NY 08-14-2015 1 136 11964202 1 0001157524 028-10410 ORBIMED CAPITAL LLC INFORMATION TABLE 2 infotable.xml ABBOTT LABS COM 002824100 10356 211000 SH DFND 1 53000 0 158000 ABBVIE INC COM 00287Y109 447821 6665000 SH DFND 1 2926000 0 3739000 ABBVIE INC COM 00287Y109 20157 300000 SH Call DFND 1 120300 0 179700 ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 80857 4411186 SH SOLE 4411186 0 0 ADURO BIOTECH INC COM 00739L101 32317 1065522 SH SOLE 1065522 0 0 ADVAXIS INC COM NEW 007624208 15351 755100 SH DFND 1 0 0 755100 AETNA INC NEW COM 00817Y108 12236 96000 SH DFND 1 26000 0 70000 AFFIMED N V COM N01045108 78323 5814630 SH SOLE 5814630 0 0 AFFYMETRIX INC COM 00826T108 82020 7511000 SH DFND 1 2295000 0 5216000 AGILENT TECHNOLOGIES INC COM 00846U101 141511 3668000 SH DFND 1 1560300 0 2107700 ALEXION PHARMACEUTICALS INC COM 015351109 369566 2044400 SH DFND 1 768300 0 1276100 ALIMERA SCIENCES INC COM 016259103 6915 1500000 SH DFND 1 670000 0 830000 ALLERGAN PLC SHS G0177J108 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