Managing Member

0001172661-15-001221.txt : 20150515 0001172661-15-001221.hdr.sgml : 20150515 20150515163122 ACCESSION NUMBER: 0001172661-15-001221 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20150331 FILED AS OF DATE: 20150515 DATE AS OF CHANGE: 20150515 EFFECTIVENESS DATE: 20150515 FILER: COMPANY DATA: COMPANY CONFORMED NAME: ORBIMED ADVISORS LLC CENTRAL INDEX KEY: 0001055951 IRS NUMBER: 133976876 STATE OF INCORPORATION: DE FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-06774 FILM NUMBER: 15870044 BUSINESS ADDRESS: STREET 1: 601 LEXINGTON AVENUE STREET 2: 54TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10022 BUSINESS PHONE: (212) 739-6400 MAIL ADDRESS: STREET 1: 601 LEXINGTON AVENUE STREET 2: 54TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10022 13F-HR 1 primary_doc.xml 13F-HR LIVE false true false 0001055951 XXXXXXXX 03-31-2015 03-31-2015 false ORBIMED ADVISORS LLC

601 Lexington Avenue 54th Floor New York NY 10022

13F HOLDINGS REPORT 028-06774 N Samuel D. Isaly Managing Member 212-739-6400 /s/ Samuel D. Isaly New York NY 05-15-2015 1 135 11714377 1 0001157524 028-10410 ORBIMED CAPITAL LLC INFORMATION TABLE 2 infotable.xml ABBOTT LABS COM 002824100 9776 211000 SH DFND 1 53000 0 158000 ABBVIE INC COM 00287Y109 281864 4814900 SH DFND 1 2156000 0 2658900 ACHILLION PHARMACEUTICALS IN COM 00448Q201 1558 158000 SH DFND 1 0 0 158000 ACTAVIS PLC SHS G0083B108 469700 1578187 SH DFND 1 728101 0 850086 ACTAVIS PLC SHS G0083B108 148810 500000 SH Call DFND 1 199300 0 300700 ACTAVIS PLC PFD CONV SER A G0083B116 105450 104200 SH DFND 1 30300 0 73900 ADVAXIS INC COM NEW 007624208 6211 430100 SH DFND 1 0 0 430100 AETNA INC NEW COM 00817Y108 10014 94000 SH DFND 1 24000 0 70000 AFFIMED N V COM N01045108 36632 5814630 SH SOLE 5814630 0 0 AFFYMETRIX INC COM 00826T108 92329 7351000 SH DFND 1 2135000 0 5216000 AGILENT TECHNOLOGIES INC COM 00846U101 168319 4051000 SH DFND 1 1719300 0 2331700 AKORN INC COM 009728106 2376 50000 SH Call DFND 1 20100 0 29900 ALEXION PHARMACEUTICALS INC COM 015351109 98036 565700 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